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Visual field defects of the contralateral eye of non-arteritic ischemic anterior optic neuropathy: are they related to sleep apnea?

  • Neurophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate whether obstructive sleep apnea (OSA) is responsible for the visual field defects found in the fellow eyes of patients with non-arteritic ischemic optic neuropathy (NAION).

Methods

Prospective cross-sectional study. The visual fields of the fellow eyes of NAION subjects with OSA were compared to the visual fields of control OSA patients matched for OSA severity. All patients underwent comprehensive ophthalmological and general examination including Humphrey 24.2 SITA-Standard visual field and polysomnography. Visual field defects were classified according the Ischemic Optic Neuropathy Decompression Trial (IONDT) classification.

Results

From a cohort of 78 consecutive subjects with NAION, 34 unaffected fellow eyes were compared to 34 control eyes of subjects matched for OSA severity (apnea–hypopnea index [AHI] 35.5 ± 11.6 vs 35.4 ± 9.4 events per hour, respectively, p = 0.63). After adjustment for age and body mass index, all visual field parameters were significantly different between the NAION fellow eyes and those of the control OSA groups, including mean deviation (−4.5 ± 3.7 vs −1.3 ± 1.8 dB, respectively, p < 0.05), visual field index (91.6 ± 10 vs 97.4 ± 3.5%, respectively, p = 0.002), pattern standard deviation (3.7 ± 2.3 vs 2.5 ± 2 dB, respectively, p = 0.015), and number of subjects with at least one defect on the IONDT classification (20 vs 10, respectively, p < 0.05).

Conclusions

OSA alone does not explain the visual field defects frequently found in the fellow eyes of NAION patients.

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Acknowledgements

The authors thank N. Arnol (MSc, INSERM U1042, Hypoxia and Physiopathology Laboratory, Joseph Fourier University, Grenoble, F-38041, France) who performed the statistical analysis.

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Authors and Affiliations

  1. Université Grenoble Alpes, F-38041, Grenoble, France

    Florent Aptel, Nischal Aryal-Charles, Renaud Tamisier, Jean-Louis Pépin, Antoine Lesoin & Christophe Chiquet

  2. Clinique Universitaire d’Ophtalmologie, CHU de Grenoble, 38043, Grenoble cedex 09, France

    Florent Aptel

  3. Department of Ophthalmology, University Hospital, CHU Grenoble, F-38043, Grenoble, France

    Florent Aptel, Nischal Aryal-Charles, Antoine Lesoin & Christophe Chiquet

  4. INSERM U1042, Lab Hypoxia and Physiopathology, Université Grenoble Alpes, Grenoble, France

    Florent Aptel, Renaud Tamisier, Jean-Louis Pépin & Christophe Chiquet

Authors
  1. Florent Aptel
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  2. Nischal Aryal-Charles
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  3. Renaud Tamisier
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  4. Jean-Louis Pépin
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  5. Antoine Lesoin
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  6. Christophe Chiquet
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Corresponding author

Correspondence to Florent Aptel.

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Funding

This research received grants from the Foundation for Medical Research “Fondation de l’Avenir” (ETO-578) and the Association for Research and Teaching in Ophthalmology (ARFO), Grenoble. The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethics approval

This study was conducted in accordance with the ethical standards of our institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individualparticipants included in the study.

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Aptel, F., Aryal-Charles, N., Tamisier, R. et al. Visual field defects of the contralateral eye of non-arteritic ischemic anterior optic neuropathy: are they related to sleep apnea?. Graefes Arch Clin Exp Ophthalmol 255, 1229–1236 (2017). https://doi.org/10.1007/s00417-017-3639-4

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  • DOI: https://doi.org/10.1007/s00417-017-3639-4

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