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Prevalence and characteristics of pseudodrusen subtypes in advanced age-related macular degeneration

  • Retinal Disorders
  • Published:
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Abstract

Purpose

The purpose of our study was to investigate the clinical and genetic characteristics of pseudodrusen subtypes and their incidence in advanced age-related macular degeneration (AMD).

Methods

We studied 84 eyes from 84 patients with pseudodrusen associated with advanced AMD, including typical AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), and geographic atrophy (GA). Multiple imaging modalities, including color fundus photography, spectral-domain optical coherence tomography (SD-OCT), near-infrared reflectance, and fundus autofluorescence, were employed to diagnose pseudodrusen and its subtypes. Subfoveal choroidal thickness was measured using SD-OCT. Subject eyes were classified into two subtypes, dot-dominant or ribbon-dominant, according to the maximum length of ribbon pseudodrusen. Genotyping was performed for ARMS2 A69S (rs10490924) and CFH I62V (rs800292) variants.

Results

The percentage of ribbon-dominant type pseudodrusen was significantly higher in eyes with RAP (69.6%) and GA (78.6%) compared with those with typical AMD (31.1%) (p = .0025 and .0017, respectively). Multivariate logistic regression analysis disclosed that incidence of female patients and coexisting large soft drusen was significantly higher in ribbon- than dot-dominant types (P = 0.014 and P = 0.008, respectively), while age, subfoveal choroidal thickness, and risk allele frequency for both ARMS2 A69S (rs10490924) and CFH I62V (rs800292) were not different between the two pseudodrusen subtypes.

Conclusions

Among eyes with advanced AMD associated with pseudodrusen, ribbon-dominant type pseudodrusen were more prevalent in eyes with GA or RAP and were associated with large soft drusen and female patients.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409-3898, Japan

    Taiyo Shijo, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Wataru Kikushima, Naohiko Tanabe & Hiroyuki Iijima

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  1. Taiyo Shijo
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  2. Yoichi Sakurada
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  3. Seigo Yoneyama
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  4. Atsushi Sugiyama
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  5. Wataru Kikushima
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  6. Naohiko Tanabe
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  7. Hiroyuki Iijima
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Corresponding author

Correspondence to Yoichi Sakurada.

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Funding

This study was supported in part by JSPS (Japan Society for the promotion of Science) KAKENHI Grant Number 26861441.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers’ bureaus, membership, employment, consultancies, stock ownership, or other equity interest, and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Shijo, T., Sakurada, Y., Yoneyama, S. et al. Prevalence and characteristics of pseudodrusen subtypes in advanced age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 255, 1125–1131 (2017). https://doi.org/10.1007/s00417-017-3622-0

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  • DOI: https://doi.org/10.1007/s00417-017-3622-0

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