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Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes

  • Retinal Disorders
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Abstract

Purpose

To compare the lesion characteristics of two different types of confocal scanning laser ophthalmoscopy (cSLO) autofluorescence (AF) images in central serous chorioretinopathy (CSC).

Methods

The study included 63 eyes of 61 patients; 63 pairs of fundus autofluorescence (FAF) images were compared before CSC resolution in 63 eyes, FAF images of 31 eyes were also compared after CSC resolution. The lesion characteristics (brightness and composite pattern) were compared between Heidelberg Retina Angiograph 2 (HRA2; Heidelberg Engineering, Germany) and Optomap Tx (Optomap; Optos, Scotland) FAF images. The lesion composite pattern was categorized as diffuse or granular. Diffuse AF was defined as homogenously increased or decreased AF, and granular AF was defined as dot-like, coarse changes in AF. The mean disease duration and subretinal fluid (SRF) height in the spectral domain optical coherence tomography were compared according to the FAF image characteristics.

Results

Lesion brightness before CSC resolution was hypo-AF in 48 eyes (76.2 %), hyper-AF in three (4.8 %), and mixed-AF in 12 (19.0 %) in HRA2 FAF images. In comparison, nine (14.3 %) images were hypo-AF, 44 (69.8 %) were hyper-AF, and 10 (15.9 %) were mixed-AF in Optomap FAF images (P < 0.0001). There was no significant difference in lesion composite pattern between the two FAF image wavelengths. Patients with lesions that were hyper-AF in Optomap FAF and hypo-AF in HRA2 FAF had a shorter disease duration and greater SRF height (1 month, 281 um) than those who were hyper-AF in both Optomap and HRA2 images (26 months, 153 um; P = 0.004, 0.001).

Conclusions

The two types of FAF images of CSC showed different lesion brightness before and after CSC resolution but demonstrated similar lesion composite patterns.

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References

  1. Eandi CM, Ober M, Iranmanesh R et al (2005) Acute central serous chorioretinopathy and fundus autofluorescence. Retina 25:989–993

    Article  PubMed  Google Scholar 

  2. Framme C, Walter A, Gabler B et al (2005) Fundus autofluorescence in acute and chronic recurrent central serous chorioretinopathy. Acta Ophthalmol Scand 83:161–167

    Article  PubMed  Google Scholar 

  3. Dinc UA, Tatlipinar S, Yenerel M et al (2011) Fundus autofluorescence in acute and chronic central serous chorioretinopathy. Clin Exp Optom 94:452–457

    Article  PubMed  Google Scholar 

  4. Spaide RF, Klancnik JM Jr (2005) Fundus autofluorescence and central serous chorioretinopathy. Ophthalmology 112:825–833

    Article  PubMed  Google Scholar 

  5. Deli A, Moetteli L, Ambresin A, Mantel I (2013) Comparison of fundus autofluorescence images acquired by the confocal scanning laser ophthalmoscope (488 nm exCitation) and the modified Topcon fundus camera (580 nm excitation). Int Ophthalmol 33:635–643

    Article  CAS  PubMed  Google Scholar 

  6. Spaide R (2008) Autofluorescence from the outer retina and subretinal space: hypothesis and review. Retina 28:5–35

    Article  PubMed  Google Scholar 

  7. Ayata A, Tatlipinar S, Kar T et al (2009) Near-infrared and short-wavelength autofluorescence imaging in central serous chorioretinopathy. Br J Ophthalmol 93:79–82

    Article  CAS  PubMed  Google Scholar 

  8. von Ruckmann A, Fitzke FW, Fan J et al (2002) Abnormalities of fundus autofluorescence in central serous retinopathy. Am J Ophthalmol 133:780–786

    Article  Google Scholar 

  9. Hanazono G, Tsunoda K, Kazato Y et al (2012) Functional topography of rod and cone photoreceptors in macaque retina determined by retinal densitometry. Invest Ophthalmol Vis Sci 53:2796–2803

    Article  PubMed  Google Scholar 

  10. Morgan JI, Pugh EN Jr (2013) Scanning laser ophthalmoscope measurement of local fundus reflectance and autofluorescence changes arising from rhodopsin bleaching and regeneration. Invest Ophthalmol Vis Sci 54:2048–5059

    Article  PubMed Central  PubMed  Google Scholar 

  11. Ojima A, Iida T, Sekiryu T et al (2011) Photopigments in central serous chorioretinopathy. Am J Ophthalmol 151:940–952

    Article  PubMed  Google Scholar 

  12. Theelen T, Berendschot TT, Boon CJ et al (2008) Analysis of visual pigment by fundus autofluorescence. Exp Eye Res 86:296–304

    Article  CAS  PubMed  Google Scholar 

  13. Bui TV, Han Y, Radu RA et al (2006) Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies. J Biol Chem 281:18112–18119

    Article  CAS  PubMed  Google Scholar 

  14. Matsumoto H, Kishi S, Sato T, Mukai R (2011) Fundus autofluorescence of elongated photoreceptor outer segments in central serous chorioretinopathy. Am J Ophthalmol 151:617–623

    Article  PubMed  Google Scholar 

  15. Campbell FW, Gubisch RW (1966) Optical quality of the human eye. J Physiol 186:558–578

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Dreher AW, Bille JF, Weinreb RN (1989) Active optical depth resolution improvement of the laser tomographic scanner Appl. Opt 28:804–808

    CAS  Google Scholar 

  17. Maass A, von Leithner PL, Luong V et al (2007) Assessment of rat and mouse RGC apoptosis imaging in vivo with different scanning laser ophthalmoscopes. Curr Eye Res 32:851–861

    Article  PubMed Central  PubMed  Google Scholar 

  18. Ahn SE, Oh J, Oh JH et al (2013) Three-dimensional Configuration of Subretinal Fluid in Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci 54:5944–5952

    Article  PubMed  Google Scholar 

  19. Song IS, Shin YU, Lee BR (2012) Time-periodic characteristics in the morphology of idiopathic central serous chorioretinopathy evaluated by volume scan using spectraldomain optical coherence tomography. Am J Ophthalmol 154:366–375

    Article  PubMed  Google Scholar 

  20. Sekiryu T, Iida T, Maruko I et al (2010) Infrared fundus autofluorescence and central serous chorioretinopathy. Invest Ophthalmol Vis Sci 51:4956–4962

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Dr. Seong-Woo Kim received a grant from Korea University (K1400629), and Dr. Jaeryung Oh received a grant (A102024) from the Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea.

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; or expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea

    Ki Tae Nam, Cheol Min Yun, Seong-Woo Kim, Jaeryung Oh & Kuhl Huh

  2. Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea

    Jee Taek Kim

  3. Department of Biostatistics, Korea niversity College of Medicine, Seoul, Korea

    Kyung-Sook Yang

  4. Korea University College of Medicine, Seoul, Korea

    Hyun Joo Kim

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  1. Ki Tae Nam
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  2. Cheol Min Yun
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Correspondence to Seong-Woo Kim.

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Nam, K.T., Yun, C.M., Kim, J.T. et al. Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes. Graefes Arch Clin Exp Ophthalmol 253, 2121–2127 (2015). https://doi.org/10.1007/s00417-015-2958-6

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  • DOI: https://doi.org/10.1007/s00417-015-2958-6

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