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Improvement of mild retinopathy in type 2 diabetic patients correlates with narrowing of retinal arterioles. A prospective observational study

  • Retinal Disorders
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Abstract

Purpose

Diabetic retinopathy is one of the leading causes of blindness in the Western world. The disease is characterized by morphological lesions secondary to disturbances in retinal blood flow assumed to be related to disturbances in retinal autoregulation. However, there is a need for elucidating the relation between disturbances in diameter regulation of retinal vessels and the development of diabetic retinopathy in longitudinal studies.

Methods

Sixty-four patients with type 2 diabetes mellitus were subjected to measurement of pressure autoregulation of retinal arterioles using the Dynamic Vessel Analyzer (DVA) and measurement of retinal thickness using OCT scanning, and after a mean of 6.8 years, 42 of the patients were re-examined. The vascular response was compared in patients in whom retinopathy had disappeared, was unchanged, or had worsened.

Results

At baseline, hemoglobin A1c (HbA1c) was significantly higher in the patients who would later experience worsening of diabetic retinopathy than in the other groups, but had been reduced at the follow-up examination. During the follow-up period, the resting diameter of retinal arterioles decreased significantly in the patients who experienced improvement in diabetic retinopathy but was unchanged in the other groups, whereas both the diameter response of retinal arterioles to isometric exercise and retinal thickness increased non-significantly with worsening of retinopathy.

Conclusions

The development of diabetic retinopathy is related to the diameter of retinal arterioles. Future clinical intervention studies should aim at investigating the effects of normalizing arteriolar diameters in diabetic retinopathy.

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Acknowledgments

This study was supported by the VELUX Foundation, which had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Ophthalmology, Aarhus University Hospital, 8000, Aarhus C, Denmark

    Line Pedersen, Peter Jeppesen & Toke Bek

  2. Department of Endocrinology, Aarhus University Hospital, 8000, Aarhus C, Denmark

    Søren Tang Knudsen & Per Løgstrup Poulsen

Authors
  1. Line Pedersen
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  2. Peter Jeppesen
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  3. Søren Tang Knudsen
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  4. Per Løgstrup Poulsen
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  5. Toke Bek
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Corresponding author

Correspondence to Line Pedersen.

Additional information

The authors had full control of the primary data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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Pedersen, L., Jeppesen, P., Knudsen, S.T. et al. Improvement of mild retinopathy in type 2 diabetic patients correlates with narrowing of retinal arterioles. A prospective observational study. Graefes Arch Clin Exp Ophthalmol 252, 1561–1567 (2014). https://doi.org/10.1007/s00417-014-2614-6

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  • DOI: https://doi.org/10.1007/s00417-014-2614-6

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