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Action fluency identifies different sex, age, global cognition, executive function and brain activation profile in non-demented patients with Parkinson’s disease

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Abstract

Patients with Parkinson’s disease (PD) have difficulties processing action words, which could be related to early cognitive decline. The action fluency test can be used to quickly and easily assess the processing of action words in PD. The goal of this study was to characterize how the action fluency test relates to personal characteristics, disease factors, cognition, and neural activity in PD. Forty-eight participants with PD (34 male, 14 female) and 35 control participants (16 male, 19 female) completed functional neuroimaging using a set-shifting task and a neuropsychological assessment including the action fluency test. PD participants with a score one standard deviation below the norm or lower on the action fluency test were identified. All PD participants with poor performance (PD-P, n = 15) were male. They were compared to male PD participants with scores within the normal range (PD-N, n = 19) and male healthy controls (HC, n = 16). PD-P were older, had lower global cognition scores, lower executive functions scores, and decreased activity in fronto-temporal regions compared with PD-N. There was no difference between the two PD groups in terms of the duration of the disease, dose of dopaminergic medication, and severity of motor symptoms. PD-N were younger than HC, but there was no other significant difference between these groups. The action fluency test identified a subgroup of PD patients with distinct sex, age, global cognition, executive functions, and brain activity characteristics. Implications for the evaluation of cognition are discussed.

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Funding

This work was supported by a Canadian Institutes of Health Research (CIHR) Fellowship to N.A.O. (grant number FAH-381468), a postdoctoral fellowship from Parkinson Alberta to A.H., a project grant from the CIHR (grant number PJT-166123), the Canada Research Chair in non-motor deficits of Parkinson’s disease, and the Tourmaline Oil Chair in Parkinson's Disease to O.M. N.A.O. and A.H. are supported by Research Scholar Junior 1 Salary Awards from the Fonds de Recherche en Santé du Québec (FRQS).

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Authors and Affiliations

  1. Faculty of Medicine, School of Communication Sciences and Disorders, McGill University, 2001 McGill College, 8th floor, Montreal, QC, H3A 1G1, Canada

    Noémie Auclair-Ouellet

  2. Centre for Research on Brain, Language and Music, Montreal, Canada

    Noémie Auclair-Ouellet

  3. Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Canada

    Noémie Auclair-Ouellet, Alexandru Hanganu, Erin L. Mazerolle, Stefan T. Lang, Mekale Kibreab, Mehrafarin Ramezani, Angela Haffenden, Tracy Hammer, Jenelle Cheetham, Iris Kathol, G. Bruce Pike, Justyna Sarna, Davide Martino & Oury Monchi

  4. Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada

    Noémie Auclair-Ouellet, Alexandru Hanganu, Erin L. Mazerolle, Stefan T. Lang, Mekale Kibreab, Mehrafarin Ramezani, Angela Haffenden, Tracy Hammer, Jenelle Cheetham, Iris Kathol, G. Bruce Pike, Justyna Sarna, Davide Martino & Oury Monchi

  5. Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, Montreal, Canada

    Noémie Auclair-Ouellet & Alexandru Hanganu

  6. Département de Psychologie, Faculté des Arts et des Sciences, Université de Montréal, Montreal, Canada

    Alexandru Hanganu

  7. Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada

    Erin L. Mazerolle & G. Bruce Pike

  8. Department of Neurology and Neurosurgery, McGill University, Montreal, Canada

    G. Bruce Pike & Oury Monchi

  9. Département de Radiologie, Faculté de Médecine, Université de Montréal, Montreal, Canada

    Oury Monchi

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  1. Noémie Auclair-Ouellet
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  2. Alexandru Hanganu
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  9. Jenelle Cheetham
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Correspondence to Noémie Auclair-Ouellet.

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Auclair-Ouellet, N., Hanganu, A., Mazerolle, E.L. et al. Action fluency identifies different sex, age, global cognition, executive function and brain activation profile in non-demented patients with Parkinson’s disease. J Neurol 268, 1036–1049 (2021). https://doi.org/10.1007/s00415-020-10245-3

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