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CHA2DS2-VASc score as predictor of stroke and all-cause death in stable ischaemic heart disease patients without atrial fibrillation

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Abstract

Background

Cerebrovascular and coronary artery disease share risk factors. The aim was to study CHA2DS2-VASc score as predictor of stroke incidence and death in a sample of patients with sinus rhythm and stable ischemic heart disease (sIHD) during long-term follow-up.

Methods

1184 patients with sIHD and without atrial fibrillation were included in this single-centre prospective cohort study between February 2000 and January 2004. Stroke and death prediction abilities of CHA2DS2-VASc score in this population were investigated.

Results

The median age was 66 (interquartile range (IQR), 60–73 years). The mean follow-up was 11.2 ± 10 years (maximum 17 years). Along this period, 137 patients (11.6% of the sample) suffered a stroke. The mean value of CHA2DS2-VASc score was 3.04 ± 1.36, with CHA2DS2-VASc score ≤ 4 in 85.5% of the sample. Higher CHA2DS2-VASc score at baseline was associated with higher risk of suffering stroke (Hazard Ratio = 1.36, 95% CI 1.20–1.54, p < 0,001) and all-cause death during follow-up (Hazard Ratio = 1.49, 95% CI 1.40–1.58, p < 0,001).

Conclusions

Higher CHA2DS2-VASc score values were associated with higher risk of stroke and all-cause mortality during long-term follow-up in this real-world sample of patients with sIHD in sinus rhythm.

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This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Cardiology Department, Hospital Puerta del Mar, Ana de Viya Avenue, 21, Cádiz, Spain

    Jose J. Sanchez Fernandez & Francisca Montoro Ballesteros

  2. Cardiology Department, Hospital Reina Sofía, Cordoba, Spain

    Martín Ruiz Ortiz, Cristina Ogayar Luque, Elías Romo Penas, Mónica Delgado Ortega & Dolores Mesa Rubio

Authors
  1. Jose J. Sanchez Fernandez
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  2. Martín Ruiz Ortiz
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  3. Francisca Montoro Ballesteros
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  4. Cristina Ogayar Luque
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  6. Mónica Delgado Ortega
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  7. Dolores Mesa Rubio
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Correspondence to Jose J. Sanchez Fernandez.

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Sanchez Fernandez, J.J., Ortiz, M.R., Ballesteros, F.M. et al. CHA2DS2-VASc score as predictor of stroke and all-cause death in stable ischaemic heart disease patients without atrial fibrillation. J Neurol 267, 3061–3068 (2020). https://doi.org/10.1007/s00415-020-09961-7

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  • DOI: https://doi.org/10.1007/s00415-020-09961-7

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