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Testing the validity of a set of diagnostic criteria for sensory neuronopathies: a francophone collaborative study

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Abstract

There are no validated criteria for the diagnosis of sensory neuronopathy (SNN) yet. In a preliminary monocenter study a set of criteria relying on clinical and electrophysiological data showed good sensitivity and specificity for a diagnosis of probable SNN. The aim of this study was to test these criteria on a French multicenter study. 210 patients with sensory neuropathies from 15 francophone reference centers for neuromuscular diseases were included in the study with an expert diagnosis of non-SNN, SNN or suspected SNN according to the investigations performed in these centers. Diagnosis was obtained independently from the set of criteria to be tested. The expert diagnosis was taken as the reference against which the proposed SNN criteria were tested. The set relied on clinical and electrophysiological data easily obtainable with routine investigations. 9/61 (16.4 %) of non-SNN patients, 23/36 (63.9 %) of suspected SNN, and 102/113 (90.3 %) of SNN patients according to the expert diagnosis were classified as SNN by the criteria. The SNN criteria tested against the expert diagnosis in the SNN and non-SNN groups had 90.3 % (102/113) sensitivity, 85.2 % (52/61) specificity, 91.9 % (102/111) positive predictive value, and 82.5 % (52/63) negative predictive value. Discordance between the expert diagnosis and the SNN criteria occurred in 20 cases. After analysis of these cases, 11 could be reallocated to a correct diagnosis in accordance with the SNN criteria. The proposed criteria may be useful for the diagnosis of probable SNN in patients with sensory neuropathy. They can be reached with simple clinical and paraclinical investigations.

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Conflicts of interest

This study was supported by a grant from the French Ministry of Health (PHRC Inter-Regional 2006 and 2010 API 28-01). None of the authors have financial relationship with the organization that sponsored the research.

Ethical standards

The study was approved by the Ethics Committee of the University Hospital of Saint-Etienne, France. For patients seen before 2011 being a retrospective non interventional study informed consent was not necessary while patients seen from 2011 onward signed an informed consent.

Author information

Authors and Affiliations

  1. Centre de Référence Maladies Neuromusculaires Rares Rhône-Alpes, CHU de Saint-Etienne, Saint-Étienne, France

    Jean-Christophe Antoine, Florence Robert-Varvat, Francesco Rotolo & Jean-Philippe Camdessanché

  2. Université de Lyon, Saint-Étienne, France

    Jean-Christophe Antoine & Jean-Philippe Camdessanché

  3. INSERM U1028, Lyon Neuroscience Research Center, Lyon, France

    Jean-Christophe Antoine & Jean-Philippe Camdessanché

  4. Centre de Référence Maladies Neuromusculaires Rares, Hôpital de la Salpêtrière, Paris, France

    Thierry Maisonobe & Karine Viala

  5. Service de Neurologie, Hôpital Henri Mondor, Créteil, France

    Alain Créange & Jean-Pascal Lefaucheur

  6. Centre de Référence des Maladies Neuromusculaires et de la SLA, Hôpital de La Timone, Marseille, France

    Jérôme Franques & Jean Pouget

  7. Service de Neurologie, CHU de Poitiers, Poitiers, France

    Stéphane Mathis

  8. Centre de Référence des Maladies Neuromusculaires et SLA, CHU de Nice, Nice, France

    Emilien Delmont & Claude Desnuelle

  9. Unité Nerf-Muscle, Service de Neurologie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland

    Thierry Kuntzer

  10. Service de Neurologie, CHU de Strasbourg, Strasbourg, France

    Andoni Echaniz-Laguna

  11. Service de Neurologie, Hôpital Nord, 42055, Saint-Etienne cedex 02, France

    Jean-Christophe Antoine

Authors
  1. Jean-Christophe Antoine
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  2. Florence Robert-Varvat
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  3. Thierry Maisonobe
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  4. Alain Créange
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  5. Jérôme Franques
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  6. Stéphane Mathis
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  7. Emilien Delmont
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  8. Thierry Kuntzer
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  9. Jean-Pascal Lefaucheur
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  10. Jean Pouget
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  11. Karine Viala
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  12. Claude Desnuelle
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  13. Andoni Echaniz-Laguna
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  14. Francesco Rotolo
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  15. Jean-Philippe Camdessanché
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Consortia

The French CIDP study group

Corresponding author

Correspondence to Jean-Christophe Antoine.

Additional information

Members of the French CIDP study group are listed in “Appendix”.

Electronic supplementary material

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Supplementary material 1 (PDF 42 kb)

Appendix

Appendix

Other members of the French CIDP group who provided cases for the study are, in alphabetical order, Françoise Bouhour, CHU de Lyon, France; Pierre Clavelou, CHU de Clermont-Ferrand, France; Andoni Echaniz-Laguna, CHU de Strasbourg, France; Hélène Gervais-Bernard, CHU de Lyon, France; Joerg Kleeberg, CHUV Lausanne, Switzerland; Emeline Lagrange, CHU de Grenoble, France; Jean-Marc Leger, Hôpital de la Salpetrière, Paris, France; Guillaume Nicolas, CHU Angers, France; François Ochsner, La Chaux-de-Fond, Switzerland; Yann Péréon, CHU de Nantes, France; Philippe Petiot, CHU Lyon, France; Pierre Soichot, CHU de Dijon, France; Guillaume Taïeb, CHU de Nîmes, France; Jean-Michel Vallat, CHU de Limoges, France; Christophe Vial, CHU Lyon, France.

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Antoine, JC., Robert-Varvat, F., Maisonobe, T. et al. Testing the validity of a set of diagnostic criteria for sensory neuronopathies: a francophone collaborative study. J Neurol 261, 2093–2100 (2014). https://doi.org/10.1007/s00415-014-7423-7

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  • DOI: https://doi.org/10.1007/s00415-014-7423-7

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