Skip to main content
Log in

Hidden administration of 5-APB in a dancing club of New Caledonia documented by urine analysis: about 3 cases

  • Case Report
  • Published:
International Journal of Legal Medicine Aims and scope Submit manuscript

Abstract

1-Benzofuran-5-ylpropan-2-amine or 5-APB is a new psychoactive substance (NPS) with empathic effects close to ecstasy (MDMA). Although 5-APB has been observed in fatality cases, the drug has not yet been reported in the context of hidden administration for behaviour impairment, also known as drug-facilitated crime. Such a situation was recently observed on 3 separate occasions in the same dancing club of New Caledonia. It involves 3 women, aged 27, 29, and 33 years who presented, after having drunk a cocktail, anxiety, abnormal movements of the inferior jaw, and aggressiveness. No memory loss was noticed. About 12 h after the event, a urine specimen was collected in the 3 cases. Comprehensive toxicology was requested and only 5-APB was identified, at 6, 8, and 14 ng/mL. Urine ethanol tested negative, which is consistent with the limited intake before the event occurred. These results have demonstrated that NPS are circulating in New Caledonia, which was not previously reported, and that 5-APB, like ecstasy, can be used to modify the behaviour of a subject, as it can be done by a chemical weapon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Poulsen H, McCarthy MJ, Baker J, Verma A, Moir HJ, Brodie T, Thatti B, Trotter G, Rooney B (2021) Toxicological assessment of the role of alcohol and drugs in drug-facilitated sexual assault cases in New Zealand. J Anal Toxicol 45:44–52

    Article  CAS  Google Scholar 

  2. Wille SMR, Van Dick K, Van Assche A, Di Fazio V, Ramirez-Fernandez MDM, Vanvooren V, Samyn N (2021) The interest of a systematic toxicological analysis combined with forensic advice to improve the judicial investigation and final judgement in drug facilitated sexual assault cases. Pharmaceuticals 14:432. https://doi.org/10.3390/ph14050432

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kintz P, Raul JS (2016) Entactogènes (MDMA) et soumission chimique. Rev Med Leg 7:71–74

    Google Scholar 

  4. Scott-Ham M, Burton FC (2005) Toxicological findings in cases of alleged drug-facilitated sexual assault in the United Kingdom over a 3-year period. J Clin Forensic Med 12:175–186

    Article  Google Scholar 

  5. Eiden C, Cathala P, Fabresse N, Galea Y, Mathieu-Daudé JC, Baccino E, Peyrière H (2013) A case of drug-facilitated sexual assault involving 3,4-methylenedioxy-methamphetamine. J Psychoactive Drugs 45:94–97

    Article  Google Scholar 

  6. Brandt SD, Walters HM, Partilla JS, Blough BE, Kavanagh PV, Baumann MH (2020) The psychoactive aminoalkylbenzofluran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats. Psychopharmacol 237:3703–3714

    Article  CAS  Google Scholar 

  7. Perez Orts M, van Asten A, Kohler I (2022) The evolution towards designer benzodiazepines in drug-facilitated sexual assault cases. J Anal Toxicol. https://doi.org/10.1093/jat/bkac017

    Article  PubMed  Google Scholar 

  8. Larabi IA, Martin M, Etting I, Penot P, Fabresse N, Alvarez JC (2018) Drug-facilitated sexual assault (DFSA) involving 4-methylethylcathinone (4-MEC), 3,4-methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis. Drug test Anal. https://doi.org/10.1002/dta.2377

    Article  PubMed  Google Scholar 

  9. Brandt SD, Walters HM, Partilla JS, Blough BE, Kavanagh PV, Baumann MH (2020) The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats. Psychopharmacol 237:3703–3714

    Article  CAS  Google Scholar 

  10. Jamey C, Kintz P, Martrille L, Raul JS (2016) Fatal combination with 3-methylmethcathinone (3-MMC) and gamma-hydroxybutyric acid (GHB). J Anal Toxicol 40:546–552

    Article  CAS  Google Scholar 

  11. Ameline A, Garnier D, Gheddar L, Richeval C, Gaulier JM, Raul JS, Kintz P (2019) Identification and analytical characterization of seven NPS, by combination of 1H NMR spectroscopy, GC-MS and UPLC-MS/MS to resolve a complex toxicological fatal case. Forensic Sci Int 298:140–148

    Article  CAS  Google Scholar 

  12. Adamowics P, Zuba D, Byrska B (2014) Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB). Forensic Sci Int 245:126–132

    Article  Google Scholar 

  13. Hofmann V, Sundermann TR, Landmann A, Rechtsteiner S, Schmitt G, Bartel M (2021) Simultaneous determination of 5- and 6-APB in blood, other body fluids, hair and various tissues by HPLC-MS/MS. J Anal Toxicol. https://doi.org/10.1093/jat/bkab018

    Article  Google Scholar 

  14. McIntyre IM, Gary RD, Trochta A, Stolberg S, Stabley R (2015) Acute 5-(2-aminopropyl)benzofuran (5-APB) intoxication and fatality: a case report with post-mortem concentrations. J Anal Toxicol 39:156–159

    Article  CAS  Google Scholar 

  15. https://www.erowid.org/experiences/subs/exp_5APB.shtml, accessed 24 March 2022

  16. Mohamed WMY, Hamida SB, Cassel JC, de Vasconcelos AP, Jones BC (2011) MDMA: interactions with other psychoactive drugs. Pharmacol Biochem Behav 99:759–774

    Article  CAS  Google Scholar 

  17. Welter J, Kavanagh P, Meyer MR, Maurer HH (2015) Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MS(n) techniques. Anal Bioanal Chem 407:1371–1388

    Article  CAS  Google Scholar 

  18. Welter-Luedeke J, Maurer HH (2016) New psychoactive substances: chemistry, pharmacology, metabolism, and detectability of amphetamine derivatives with modified ring systems. Ther Drug Monit 38:4–11

    Article  CAS  Google Scholar 

  19. Jamey C, Kintz P, Martrille L, Raul JS (2016) Fatal combination with 3-methylmethcathinone (3-MMC) and gamma-hydroxybutyric acid (GHB). J Anal Toxicol 40:546–552

    Article  CAS  Google Scholar 

  20. Aknouche F, Ameline A, Kernalleguen A, Arbouche N, Maruejouls C, Kintz P (2021) Toxicological investigations in a death involving 2,5-dimethoxy-4-chloroamphetamine (DOC) performed on an exhumed body. J Anal Toxicol 45:e1–e7

    Article  CAS  Google Scholar 

  21. Busardo FP, Gottardi M, Pacifici R, Vari MR, Tini A, Volpe AR, Giorgetti R, Pichini S (2020) Nails analysis for drugs used in the context of chemsex: a pilot study. J Anal Toxicol 44:69–74

    PubMed  Google Scholar 

  22. Hagan KS, Reidy L (2015) Detection of synthetic cathinones in victims of sexual assault. Forensic Sci Int 257:71–75

    Article  CAS  Google Scholar 

  23. https://www.soft-tox.org/files/designer_drugs/5-APB.pdf, accessed 24 March 2022

  24. https://www.ofdt.fr/index.php?cID=1148, accessed 24 March 2022

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pascal Kintz.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Ethics approval

This study does not need ethical approval.

Informed consent

Not required.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aknouche, F., Ameline, A., Barguil, Y. et al. Hidden administration of 5-APB in a dancing club of New Caledonia documented by urine analysis: about 3 cases. Int J Legal Med 136, 1315–1319 (2022). https://doi.org/10.1007/s00414-022-02850-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00414-022-02850-w

Keywords

Navigation