Abstract
Autosomal short tandem repeats (STRs) are viewed as the gold standard in forensic individual identification and parentage testing. The Huaxia Platinum System contains 23 autosomal markers along with rs2032678 (Yindel) and amelogenin. Here, we genotyped 23-STRs in the southwestern Xinjiang Uyghur residing in the Artux Region and assessed the allele frequency and forensic statistical parameters. All investigated STRs are in conformity with the Hardy-Weinberg equilibrium with an effective combined power of discrimination (0.99999999999999999999999999992) and cumulative probability of exclusion (0.9999999997) in the Artux Uyghur population. Population comparisons among 54 worldwide populations via PCA and MDS indicate that the Artux Uyghur population has a close genetic relationship with geographically distinct Uyghurs and Kazakh groups than other East Asians or Eurasians. Genetic ancestry component dissection among 2198 individuals from Sinitic, Turkic, and Tibeto-Burman language groups further demonstrates the genetic homogeneity within the Turkic language family and apparent genetic heterogeneity among other language groups.
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26 February 2020
‘Concerns have been raised about the ethics approval and informed consent procedures related to the research reported in this paper. The paper includes the following author declarations: “We collected samples from 644 unrelated Uyghur people (330 males and 314 females) residing in the Artux county, southwestern Xinjiang Uyghur Autonomous Region, with the written informed consent [...]. This study was reviewed and approved by the Ethnics Committee of Affiliated Hospital of Zunyi Medical University”. Editorial action will be taken as appropriate once an investigation of the concerns is complete and all parties have been given an opportunity to respond in full.’
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (No. 81401562).
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Chen, P., Wang, B., Gao, B. et al. Forensic features and genetic structure of 23 autosomal STRs in Artux Turkic-speaking population residing in southwestern Xinjiang Uyghur Autonomous Region. Int J Legal Med 133, 1393–1395 (2019). https://doi.org/10.1007/s00414-019-02072-7
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DOI: https://doi.org/10.1007/s00414-019-02072-7