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Hair analysis does not allow to discriminate between acute and chronic administrations of a drug in young children

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Abstract

There are many differences between the hair from children and that of adult subjects, the hair being thinner, more porous with a different growth rate from the usual 1 cm/month observed in adults. In order to determine whether hair analysis could discriminate between chronic use and acute administration of a drug in children like in adults, we analyzed hair from 18 children aged between 1 day and 15 years in whom the administration of different drugs was known (single therapeutic administration or acute intoxication). A strand of hair was sampled within 1 to 45 days after treatment or intoxication. Analysis was conducted using LC/MS/MS. In the 10 youngest children, aged between 1 day and 29 months, the compounds administered in hospital or responsible for intoxication (lidocaine, ropivacaine, diazepam, midazolam, levetiracetam, morphine, ketamine, methadone, buprenorphine, THC, MDMA) were found in all segments of the hair independently of the time of sampling (1–45 days after ingestion). The concentrations detected were similar along the hair shaft, showing a radial diffusion and incorporation of the analytes in the hair of young children from the sebum. Concentrations could be very high when sampled shortly after administration (72 ng/mg for methadone, 75 ng/mg for MDMA after 3 days) and lower when sampling later (1.2 ng/mg for MDMA after 45 days). In these cases, hair analysis allowed to highlight the compounds responsible for intoxication even when they had disappeared from the blood or urine but should not be used to discriminate long-term exposure to a drug. In the eight remaining children aged from 34 months to 15 years, the drugs used in hospital (lidocaine, diazepam, morphine) or responsible for intoxication (THC, codeine, buprenorphine) were not found in any analyzed segments sampled 1 to 5 days after administration of the drugs, in agreement with the non-incorporation of the drugs from the sebum into the hair. For those children aged over 34 months, hair analysis allows to determine the chronic administration of a drug, like in adults.

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References

  1. Lemaire-Hurtel AS, Durand-Maugard C, Berquin P, Antonios M, Hary L, Andrejak M, Masson H, Manaouil C, Abe E, Alvarez JC (2010) Unexplained seizures in a newborn: think of Munchausen syndrome by proxy. Ann Toxicol Anal 22(1):11–17

    Article  Google Scholar 

  2. Kintz P, Villain M, Cirimele V (2006) Determination of trimeprazine-facilitated sedation in children by hair analysis. J Anal Toxicol 30(6):400–402

    Article  CAS  Google Scholar 

  3. Alvarez JC, Etting I, Abe E, Villa A, Fabresse N (2017) Identification and quantification of 4-methylethcathinone (4-MEC) and 3,4-methylenedioxypyrovalerone (MDPV) in hair using LC-MS/MS after chronic administration. Forensic Sci Int 270:39–45

    Article  CAS  Google Scholar 

  4. Marchei EI, Palmi I, Pacifici R, Anton Airaldi IR, Costa Orvay JA, Garcia Serra J, Bonnet Serra B, Garcia-Algar O (2016) Segmental hair testing to disclose chronic exposure to psychoactive drugs. Adicciones 28(3):158–162

    Article  Google Scholar 

  5. Villain M, Chèze M, Dumestre V, Ludes B, Kintz P (2004) Hair to document drug-facilitated crimes: four cases involving bromazepam. J Anal Toxicol 28(6):516–519

    Article  CAS  Google Scholar 

  6. Harkey MR (1993) Anatomy and physiology of hair. Forensic Sci Int 63(1–3):9–18

    Article  CAS  Google Scholar 

  7. Yang F, Zhang Y, Rheinstädter MC (2014) The structure of people’s hair. Perr J 2:e619

    Article  Google Scholar 

  8. Sinclair RD (2007) Healthy hair: what is it? J Investig Dermatol Symp Proc 12(2):2–5

    Article  Google Scholar 

  9. Wang X, Drummer OH (2015) Review: Interpretation of drug presence in the hair of children. Forensic Sci Int 257:458–472

    Article  CAS  Google Scholar 

  10. Allibe N, Eysseric-Guerin H, Kintz P, Bartoli M, Bost-Bru C, Grenier F, Scolan V, Stancke-Labesque F (2015) Amitriptyline poisoning of a baby: how informative can hair analysis be? Forensic Sci Int 249:53–58

    Article  CAS  Google Scholar 

  11. Tournel G, Pollard J, Humbert L, Wiart J-F, Hédouin V, Allorge D (2014) Use of hair testing to determine methadone exposure in pediatric deaths. J Forensic Sci 59(5):1436–1440

    Article  CAS  Google Scholar 

  12. Kintz P, Evans J, Villain M, Cirimele V (2010) Interpretation of hair findings in children after methadone poisoning. Forensic Sci Int 196(1–3):51–54

    Article  CAS  Google Scholar 

  13. Kintz P, Villain M, Dumestre-Toulet V, Capolaghi B, Cirimele V (2006) Methadone as a chemical weapon: two fatal cases involving babies. Ther Drug Monit 27(6):741–743

    Article  Google Scholar 

  14. Papaseit E, Corrales O, Stramesi C, Vall O, Palomeque A, Garcia-Algar O (2010) Postnatal methadone withdrawal syndrome: hair analysis for detecting chronic exposure. Acta Paediatr 99(2):162–163

    PubMed  Google Scholar 

  15. Chatterton C, Turner K, Klinger N, Etter M, Duez M, Cirimiele V (2014) Interpretation of pharmaceutical drug concentrations in young children's head hair. J Forensic Sci 59(1):281–286

    Article  CAS  Google Scholar 

  16. Gaillard Y, Breuil R, Doche C, Romeuf L, Lemeur C, Prevosto J-M, Fanton L (2011) Detection of amitriptyline, nortriptyline and bromazepam in liver, CSF and hair in the homicidal poisoning of a one-month-old girl autopsied 8 months after death. Forensic Sci Int 207(1–3):e16–e18

    Article  CAS  Google Scholar 

  17. Rey-Salmon C, Pépin G (2007) Drug-facilitated crime and sexual abuse: a pediatric observation. Arch Pédiatr 14(11):1318–1320

    Article  CAS  Google Scholar 

  18. Pragst F, Broecker S, Hastedt M, Herre S, Andresen-Streichert H, Sachs H, Tsokos M (2013) Methadone and illegal drugs in hair from children with parents in maintenance treatment or suspected for drug abuse in a German community. Ther Drug Monit 35(6):737–752

    Article  CAS  Google Scholar 

  19. Kintz P (2014) Interpretation of hair findings in children: about a case involving carbamazepine. Drug Test Anal 6(1):2–4

    Article  CAS  Google Scholar 

  20. Kronstrand R, Scott K (2006) Drug incorporation in hair in analytical and practical aspects of drug testing in hair. CRC Press, Boca Raton, pp 1–23

    Google Scholar 

  21. Al-Adwani A, Basu N (2004) Methadone and excessive sweating. Addiction 99(2):259

    CAS  PubMed  Google Scholar 

  22. Millar SE, Willert K, Salinas PC (1999) WNT signaling in the control of hair growth and structure. Dev Biol 207(1):133–149

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Pharmacology–Toxicology, AP-HP, INSERM U-1173, Raymond Poincaré University Hospital, Versailles Saint Quentin-en-Yvelines University, 104 Boulevard Raymond Poincaré, 92380, Garches, France

    Jean Claude Alvarez, Laetitia Lasne, Isabelle Etting, Nicolas Fabresse & Islam Amine Larabi

  2. Pediatric Emergency Department, Necker-Enfants Malades, Université Paris-Descartes, 149, rue de Sèvres, 7574, Paris Cedex 15, France

    Gérard Chéron

  3. Pediatric Department, Necker-Enfants Malades, Université Paris-Descartes, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    Véronique Abadie

Authors
  1. Jean Claude Alvarez
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  2. Laetitia Lasne
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  3. Isabelle Etting
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  4. Gérard Chéron
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  5. Véronique Abadie
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  6. Nicolas Fabresse
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  7. Islam Amine Larabi
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Correspondence to Jean Claude Alvarez.

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Alvarez, J.C., Lasne, L., Etting, I. et al. Hair analysis does not allow to discriminate between acute and chronic administrations of a drug in young children. Int J Legal Med 132, 165–172 (2018). https://doi.org/10.1007/s00414-017-1720-5

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  • DOI: https://doi.org/10.1007/s00414-017-1720-5

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