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Population genetic analysis of the Globalfiler STR loci in 3032 individuals from the Altay Han population of Xinjiang in northwest China

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Abstract

The genetic polymorphisms of 21 autosomal short tandem repeat (STR) loci included in the GlobalFiler™ PCR Amplification Kit were evaluated in 3032 unrelated individuals Altay Han of Xinjiang, northwest China. All of the loci reached the Hardy-Weinberg equilibrium. These loci were examined to determine allele frequencies and forensic statistical parameters. SE33 showed the greatest power of discrimination in Altay Han population, whereas TPOX showed the lowest. The combined discrimination power and probability of excluding paternity of the 21 autosomal STR loci were 0.999999999999999999999999889838 and 0.999999996664704, respectively. Both pairwise genetic distance and phylogenetic methods indicated that the Altay Han had the closest genetic relationship with the Han origin and Hui populations. The present results revealed that the GlobalFiler system had a high level of polymorphism in Altay Han population and hence could be a powerful tool for forensic application and population genetic study.

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Acknowledgements

This study was supported by the Department of Education, Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases (No. 2015064), Natural Science Foundation of Shandong Province (No. ZR2014HQ018). National Natural Science Foundation Council of China (No. 81671874). Project of Shandong Province Higher Educational Science and Technology Program (No. J17KA240), China Postdoctoral Science Foundation (No. 2017M612701).

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Authors and Affiliations

  1. Department of Forensic Medicine, Shantou University Medical College, 22 Xinling Road, Shantou, 515041, Guangdong, People’s Republic of China

    XueBo Li & Xiaojun Yu

  2. Key Laboratory of Evidence Identification in Universities of Shandong Province, Shandong University of Political Science and Law, Jinan, 250014, Shandong, People’s Republic of China

    XueBo Li & Liangliang Li

  3. Chongqing Public Security Bureau, Institute of Forensic Science, Chongqing, 400021, China

    Qingshan Wang

  4. Altay Public Security Bureau of Xinjiang Uygur Autonomous Region, Altay, 836500, China

    Jianzhong Zhang

  5. Key Laboratory of Criminal Science and Technology of Fujian Province, Fujian Province Public Security Department, Institute of Forensic Science, Fuzhou, 350003, China

    Wendong Ge

  6. Key Laboratory of Evidence Science, Ministry of Education, China University of Political Science and Law, 25 Xitucheng Road, Beijing, 100088, China

    Rufeng Bai & Meisen Shi

Authors
  1. XueBo Li
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  2. Liangliang Li
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  3. Qingshan Wang
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  4. Jianzhong Zhang
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  5. Wendong Ge
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  6. Rufeng Bai
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  7. Xiaojun Yu
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  8. Meisen Shi
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Corresponding authors

Correspondence to Xiaojun Yu or Meisen Shi.

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Electronic supplementary material

Fig. S1

The locations of Altay and other Han populations in China a: China, b: Xinjiang (DOCX 2421 kb).

Fig. S2

Multidimensional scaling (MDS) plot based on pairwise Fst values between Altay Han and other populations (DOCX 29 kb).

Fig. S3

The neighbor-joining trees constructed with pairwise Fst (DOCX 17 kb).

Table S1

Allele frequencies and forensic parameters of 21 autosomal STRs in Altay Han population living in Xinjiang, China (n=3,032) (XLSX 19.4 kb).

Table S2

P-values of LD test between 21 autosomal STR loci in Altay Han population living in Xinjiang, China (n=3,032) (XLSX 12 kb).

Table S3

P-values of population differentiation exact test between Altay Han and the reference populations (XLSX 14 kb).

Table S4

Fst values between pairwise populations in the present study by using 21 autosomal STR loci (XLSX 10 kb).

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Li, X., Li, L., Wang, Q. et al. Population genetic analysis of the Globalfiler STR loci in 3032 individuals from the Altay Han population of Xinjiang in northwest China. Int J Legal Med 132, 141–143 (2018). https://doi.org/10.1007/s00414-017-1641-3

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  • DOI: https://doi.org/10.1007/s00414-017-1641-3

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