Abstract
Alleles at the D7S820 STR locus have 6–14 different numbers of a four-nucleotide (GATA) repeat motif arranged in tandem. The D7S820 tri-allelic pattern is rare and has not been reported in the Chinese population. In this study we report a three-banded pattern at the D7S820 locus observed in a Chinese family, in which four family members in two generations had tri-allelic D7S820 genotype 10-11-12 and one family member had an abnormal bi-allele genotype 10–11. All of the four tri-allelic cases had the genotype 10-11-12, probably due to three copies of the D7S820 STR sequence in all cells (Type 2 tri-allelic pattern), and deduced alleles 10–11 were a linked inheritance in this family.
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Acknowledgments
This article presents independent research funded by the Shanghai Tissuebank Biotechnology Co.,LTD and supported by the Tianjin Hematonosis Hospital Hematology Department. The views expressed are those of the author(s).
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This study complies with the current laws and ethical standards required in China.
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The authors declare that they have no conflict of interest.
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Jiang, E., Pan, J., Han, M. et al. Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family. Int J Legal Med 130, 23–26 (2016). https://doi.org/10.1007/s00414-015-1166-6
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DOI: https://doi.org/10.1007/s00414-015-1166-6