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Obstructive Sleep Apnea Severity, Body Mass Index, and Circulating Levels of Cellular Adhesion Molecules

  • OBSTRUCTIVE SLEEP APNEA
  • Published:
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Abstract

Purpose

To investigate the relationship between obstructive sleep apnea (OSA) severity, body mass index (BMI), and circulating levels of inflammatory adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin).

Methods

A cross-sectional clinical cohort study on all consecutive adults referred to the University of British Columbia (UBC) Sleep Laboratory for a polysomnogram (PSG) for suspected OSA provided a morning blood sample. Samples were analyzed with multiplex immune assay (MilliporeSigma, CA) to assess the levels of adhesion molecules.

Results

488 patients were studied; the majority were male (68%) with a mean age of 50 yrs, mean AHI of 23 events/hour, and mean BMI of 32 kg/m2. In multivariable linear regression models, all three adhesion molecules were significantly associated with BMI (E-selectin p < 0.0001; ICAM-1 p = 0.0007; VCAM-1 p = 0.0003). However, only E-selectin was independently associated with AHI (p = 0.02); there was no significant interaction between AHI and BMI for E-selectin (p = 0.33).

Conclusions

Although all three adhesion molecules were associated with BMI, only E-selectin was independently associated with OSA severity. Future studies are needed to determine the clinical significance of the relationship between E-selectin and OSA.

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Acknowledgements

CIHR (Sleep Disordered Breathing Team Grant), VCHRI Scientist Award, BC Lung Association Operating Grant.

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Authors and Affiliations

  1. Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada

    Bernardo U. Peres & Fernanda Almeida

  2. Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor

    A. J. Hirsch Allen, Aditi Shah, Nurit Fox, Ismail Laher, Rachel Jen & Najib T. Ayas

  3. Department of Medicine, Division of Respirology, University of Ottawa, Ottawa, Canada

    Tetyana Kendzerska

  4. Leon Judah Blackmore Sleep Disorders Program, UBC Hospita, Vancouver, Canada

    Aditi Shah, Rachel Jen & Najib T. Ayas

  5. St. Paul’s Hospital, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada

    Andrew J. Sandford & Stephan F. van Eeden

  6. Canadian Sleep and Circadian Network, Montréal, Canada

    Najib T. Ayas

Authors
  1. Bernardo U. Peres
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  2. A. J. Hirsch Allen
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  3. Tetyana Kendzerska
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  4. Aditi Shah
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  5. Nurit Fox
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  6. Ismail Laher
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  7. Fernanda Almeida
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  8. Rachel Jen
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  9. Andrew J. Sandford
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  10. Stephan F. van Eeden
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  11. Najib T. Ayas
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Correspondence to Najib T. Ayas.

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Peres, B.U., Allen, A.J.H., Kendzerska, T. et al. Obstructive Sleep Apnea Severity, Body Mass Index, and Circulating Levels of Cellular Adhesion Molecules. Lung 198, 939–945 (2020). https://doi.org/10.1007/s00408-020-00401-x

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  • DOI: https://doi.org/10.1007/s00408-020-00401-x

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