Abstract
Purpose
Chronic cough is a common problem in various populations. The present study assessed the impact of cough and unmet needs in Korean patients with chronic cough.
Methods
This cross-sectional multi-center study enrolled adult patients newly referred to clinic for assessment of chronic cough. A second group of patients with unexplained chronic cough following detailed assessment were recruited for comparison. Patients completed self-reported questionnaires, including cough characteristics, impact of cough on daily life, and unmet needs.
Results
A total of 447 subjects were recruited from six referral clinics, including 408 with chronic cough and 39 with unexplained chronic cough. Almost all patients reported that cough impacted their daily lives. Psychosocial impacts were more evident in unexplained cough patients compared to newly referred patients. Approximately 75% of newly referred patients had previously sought medical care for cough on multiple occasions, but the effectiveness of treatment was limited (70.3%) or absent (17.3%). The most frequent unmet need was the ineffectiveness of treatment (49.3%), followed by unclear diagnosis (30.1%). The majority of participants ( > 80%) expressed the need for further information on accessing cough specialists and disease management. The main problem faced by unexplained cough patients was poor cough control despite treatment (64%).
Conclusions
Chronic cough has a substantial impact on daily life and is worst in those whose cough remains unexplained following assessment. Ineffectiveness of treatment and unclear diagnosis were major unmet needs. Medical information about chronic cough was also lacking. Improvements in the management of chronic cough patients in Korea are necessary.
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References
Song WJ, Chang YS, Faruqi S, Kim JY, Kang MG, Kim S et al (2015) The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur Respir J 45:1479–1481
Morice AH, Millqvist E, Belvisi MG, Bieksiene K, Birring SS, Chung KF et al (2014) Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. Eur Respir J 44:1132–1148
Morice AH, Fontana GA, Sovijarvi AR, Pistolesi M, Chung KF, Widdicombe J et al (2004) The diagnosis and management of chronic cough. Eur Respir J 24:481–492
Irwin RS, Baumann MH, Bolser DC, Boulet LP, Braman SS, Brightling CE et al (2006) Diagnosis and management of cough executive summary: accp evidence-based clinical practice guidelines. Chest 129:1S–23S
Mcgarvey L (2013) The difficult-to-treat, therapy-resistant cough: why are current cough treatments not working and what can we do? Pulm Pharmacol Ther 26:528–531
Birring SS, Prudon B, Carr AJ, Singh SJ, Morgan MD, Pavord ID (2003) Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Thorax 58:339–343
French CL, Irwin RS, Curley FJ, Krikorian CJ (1998) Impact of chronic cough on quality of life. Arch Intern Med 158:1657–1661
Song WJ, Morice AH, Kim MH, Lee SE, Jo EJ, Lee SM et al (2013) Cough in the elderly population: relationships with multiple comorbidity. PLoS ONE 8:E78081
Chamberlain SA, Garrod R, Douiri A, Masefield S, Powell P, Bucher C et al (2015) The impact of chronic cough: a cross-sectional European Survey. Lung 193:401–408
Song DJ, Song WJ, Kwon JW, Kim GW, Kim MA, Kim MY et al (2018) KAAACI evidence-based clinical practice guidelines for chronic cough in adults and children in Korea. Allergy Asthma Immunol Res 10:591–613
Song W-J, Lee S-H, Kang M-G, Kim J-Y, Kim M-Y, Jo E-J et al (2015) Validation of the korean version of the European Community Respiratory Health Survey Screening Questionnaire for use in epidemiologic studies for adult asthma. Asia Pac Allergy 5:25–31
Morice AH (2015) Over-the-counter cough medicines: new approaches. Pulm Pharmacol Ther 35:149–151
Morice AH, Menon MS, Mulrennan SA, Everett CF, Wright C, Jackson J et al (2007) Opiate therapy in chronic cough. Am J Respir Crit Care Med 175:312–315
Ryan NM, Birring SS, Gibson PG (2012) Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet 380:1583–1589
Faruqi S, Murdoch RD, Allum F, Morice AH (2014) On the definition of chronic cough and current treatment pathways: an International Qualitative Study. Cough 10:5
Chung KF, Mcgarvey L, Mazzone SB (2013) Chronic cough as a neuropathic disorder. Lancet Respir Med 1:414–422
Song WJ, Morice AH (2017) Cough hypersensitivity syndrome: a few more steps forward. Allergy Asthma Immunol Res 9:394–402
Polley L, Yaman N, Heaney L, Cardwell C, Murtagh E, Ramsey J et al (2008) Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires. Chest 134:295–302
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Kang, SY., Won, HK., Lee, S.M. et al. Impact of Cough and Unmet Needs in Chronic Cough: A Survey of Patients in Korea. Lung 197, 635–639 (2019). https://doi.org/10.1007/s00408-019-00258-9
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DOI: https://doi.org/10.1007/s00408-019-00258-9