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Selectins and Platelet-Derived Growth Factor (PDGF) in Schistosomiasis-Associated Pulmonary Hypertension

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Abstract

Purpose

The aim of this study was to evaluate the expression profiles of the relevant selectins and PDGF in schistosomiasis-associated pulmonary hypertension.

Methodology

Patients with three distinct clinical profiles were enrolled in the study: IPAH(n = 11), schistosomiasis-associated PH (Sch-PH))(n = 13), and schistosomiasis without PH (Sch) (n = 13). Healthy volunteers, were recruited as a control group(n = 13). Echocardiography was performed in all groups, and the PH patients underwent right heart catheterization. Plasma soluble adhesion molecules E- and P-Selectin, PDGF-AB, PDGF-BB were determined by ELISA.

Results

E-selectin was significantly increased in the IPAH group compared with the other groups [the control, Sch + PH and Sch groups) (p < 0.001) (Fig. 2)]. P-selectin was lower in Sch (20.2 + 8.9 × 103 pg/mL) as compared to the control, (43 16.8 × 103 pg/mL), IPAH (35.8 7.8 × 103 pg/mL), and Sch + PH (36.8 ± 15.7 × 103 pg/mL) (p = 0.005) groups. Serum PDGF-BB levels were higher in the control group (8.9 ± 4.8 × 103 pg/mL) compared with the IPAH (3.7 ± 2.17 × 103 pg/mL), Sch + PH (5.2 ± 3.7 × 103 pg/mL) and Sch (2.4 ± 1.7 × 103 pg/mL) groups (p < 0.05). PDGF-AB levels were also higher in the control group (25.6 ± 8.6 × 103 pg/mL), compared with the other three groups, being the Sch group the one with lower serum levels of this marker (11.4 ± 8.6 × 103 pg/mL) (p = 0.006).

Conclusions

In conclusion, vascular inflammation in schistosomiasis, with or without PH, is different from IPAH suggesting distinct pathophysiological mechanisms associated with the development of pulmonary hypertension.

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Acknowledgments

We thank Carlos Sérgio Rocha da Silva from Pleura Laboratory and the MECOR course instructors, especially William Volmer.

Financial support

Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Pulmonary Division, Heart Institute (InCor) Hospital Das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Monica Lapa, Milena M. P. Acencio, Alberto Q. Farias, Lisete R. Teixeira, Caio J. C. Fernandes, Carlos P. Jardim & Mario Terra-Filho

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  1. Monica Lapa
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  2. Milena M. P. Acencio
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  3. Alberto Q. Farias
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Correspondence to Mario Terra-Filho.

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Lapa, M., Acencio, M.M.P., Farias, A.Q. et al. Selectins and Platelet-Derived Growth Factor (PDGF) in Schistosomiasis-Associated Pulmonary Hypertension. Lung 192, 981–986 (2014). https://doi.org/10.1007/s00408-014-9643-0

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