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Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia

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Abstract

Functional deficits including cognitive impairment and social dysfunction are the core symptoms of schizophrenia (SCZ), and sensory gating (SG) deficits may be involved in the pathological mechanism of functional deficits in SCZ. This study was to investigate the relationship between defective P50 inhibition and functional deficits in first-episode drug naïve (FEDN) SCZ patients. A total of 95 FEDN SCZ patients and 53 healthy controls (HC) were recruited. The Chinese version of UCSD Performance-Based Skills (UPSA), MATRICS Consensus Cognitive Battery (MCCB), and EEG system were used to assess the social function, cognitive performance, and P50 inhibition, respectively. The MCCB total score and eight domain scores were significantly lower in patients with FEDN SCZ than those in HC (all p < 0.05). The UPSA total score and financial skills scores were also significantly lower in SCZ patients than that in the HC (all p < 0.05). Compared with HC, patients with FEDF SCZ had a higher P50 ratio (all p < 0.05). There was no correlation between P50 components and MCCB scores in patients with FEDF SCZ. However, there was only a correlation between the P50 ratio and UPSA financial skills, communication skills, or total score in patients (all p < 0.05). Defective P50 inhibition in FEDN SCZ patients may be associated with social dysfunction but not cognitive impairment, suggesting that the social dysfunction and cognitive impairment of patients with FEDN SCZ may have different pathogenic mechanisms.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by CAS International Cooperation Research Program (153111KYSB20190004), Institute of Psychology, CAS (No. GJ202006), CAS Pioneer Hundred Talents Program, and the CAS Key Lab of Mental Health. The funding sources had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

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Authors and Affiliations

  1. CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China

    Dongmei Wang, Luyao Xia, Junru Guo, Yang Tian, Huixia Zhou & Xiang-Yang Zhang

  2. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China

    Dongmei Wang, Luyao Xia, Yang Tian, Huixia Zhou & Xiang-Yang Zhang

  3. Department of Psychology, Barnard College of Columbia University, New York, NY, USA

    Zhiqi Zhang

  4. Department of Psychology, Guizhou Minzu University, Guiyang, China

    Junru Guo

  5. Beijing HuiLongGuan Hospital, Peking University, Beijing, China

    Meihong Xiu & Dachun Chen

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Contributions

DW and X-YZ were responsible for study design, statistical analysis, and manuscript preparation. DC and MX were responsible for recruiting the patients, performing the clinical rating, and collecting the samples. LX, ZZ, JG, YT, and HZ were involved in evolving the ideas and editing the manuscript. All the authors have contributed to and have approved the final manuscript.

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Correspondence to Xiang-Yang Zhang.

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The research protocol was approved by the Institutional Review Board, Beijing Hui-Long-Guan Hospital. The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

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Wang, D., Xia, L., Zhang, Z. et al. Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosci (2023). https://doi.org/10.1007/s00406-023-01711-w

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