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Psychiatric comorbidity in individuals with bipolar disorder: relation with clinical outcomes and functioning

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Abstract

The aim was to assess the lifetime prevalence of psychiatric comorbidity (PC) in Brazilian euthymic individuals with bipolar disorder type I, and investigate its effects on clinical outcomes and functioning. A group of 179 outpatients with BD-I in the recuperation phase were assessed, of whom 75 (41.9%) had PC and 104 (58.1%) had not. Both groups were compared using sociodemographic/clinical questionnaire, Structured Clinical Interview for DSM-IV axis I and II, Sheehan Disability and Barratt Impulsiveness Scales. Patients with PC presented less religious affiliation, more history of lifetime psychotic symptoms, rapid cycling, suicide attempts, worse scores of functioning, and higher prevalence of personality disorders. Ordinal logistic regression indicated that PC was associated with increased odds of worse levels of disability. Therefore, it could be observed that patients with BD evaluated only in euthymia presented a high mental disorders comorbidity. Considering their burdensome impact, appropriate management is a challenging reality and a crucial factor in reducing morbidity and mortality associated with BD. Further longitudinal studies on their relationship may broaden interventions to reduce patient’s suffering.

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Acknowledgements

The authors would like to thank all the patients who consented to be included in this study for their cooperation and resilience in completing the assessments.

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Authors and Affiliations

  1. Mood and Anxiety Disorders Program (CETHA), Federal University of Bahia (UFBA), Salvador, BA, Brazil

    Gabriela Léda-Rêgo, Paula Studart-Bottó, Stella Sarmento, Severino Bezerra-Filho & Ângela Miranda-Scippa

  2. Postgraduate Program in Medicine and Health, UFBA, Salvador, BA, Brazil

    Gabriela Léda-Rêgo, Paula Studart-Bottó, Stella Sarmento & Ângela Miranda-Scippa

  3. Postgraduate Program in Health Sciences, UFBA, Salvador, BA, Brazil

    Thiago Cerqueira-Silva

  4. Department of Neurosciences and Mental Health, Medical School, UFBA, Salvador, BA, Brazil

    Ângela Miranda-Scippa

Authors
  1. Gabriela Léda-Rêgo
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  5. Severino Bezerra-Filho
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  6. Ângela Miranda-Scippa
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Contributions

GLR conceived, designed, conducted the study/analysis, as well as the writing and revision of the manuscript. PSB, SS and SBF assisted in data collection, analysis and the rational of the result’s exposure. TCS conducted the statistical analysis, and revised the manuscript. AMS managed the conduction and coordination of the study, oversaw the data analyses and contributed to the revision of the manuscript. All authors contributed to and approved the final manuscript.

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Correspondence to Gabriela Léda-Rêgo.

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Léda-Rêgo, G., Studart-Bottó, P., Sarmento, S. et al. Psychiatric comorbidity in individuals with bipolar disorder: relation with clinical outcomes and functioning. Eur Arch Psychiatry Clin Neurosci 273, 1175–1181 (2023). https://doi.org/10.1007/s00406-023-01562-5

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  • DOI: https://doi.org/10.1007/s00406-023-01562-5

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