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Regional cerebral blood flow in late-onset schizophrenia: a SPECT study using 99mTc-ECD

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An Erratum to this article was published on 16 June 2015

Abstract

Progressive disability in schizophrenia has been considered to be associated with onset-age. The objective of this study was to evaluate age onset-related degeneration in rCBF in patients with schizophrenia. We evaluated characteristic changes in brain perfusion by age, gender, medication and clinical symptoms in medicated patients with early-onset (EOS: developed at younger than 40 years old: n = 44) and late-onset (LOS: developed at older than 40 years old: n = 19) schizophrenia and control subjects matched for age and gender (n = 37) using statistical parametric mapping (SPM8) applied to 99mTc-ECD SPECT. We performed SPECT with 99mTc-ECD on the brains of subjects. A voxel-by-voxel group analysis was performed using SPM 8 and ANOVA. rCBF in EOS was found to be reduced in the precentral and inferior frontal gyri; on the other hand, rCBF was reduced in the bilateral postcentral gyrus in LOS. This study revealed a significant difference in brain perfusion between EOS and LOS. The present study might suggest that the characteristic changes in rCBF are related to onset-age in schizophrenia.

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Acknowledgments

The authors declare that there are no conflicts of interest in relation to the subject of this study. Funding came from a Junior Scientist from the Shimane University Faculty of Medicine, and Health and Labour Sciences Research Grants, Japan.

Conflict of interest

We declare that they have no conflict of interest.

Ethical standard

Our studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Authors and Affiliations

  1. Department of Psychiatry, Shimane University Faculty of Medicine, Izumo, Japan

    Rei Wake, Tsuyoshi Miyaoka, Tomoko Araki, Kazunori Kawakami, Motohide Furuya, Erlyn Limoa, Sadayuki Hashioka & Jun Horiguchi

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  1. Rei Wake
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  2. Tsuyoshi Miyaoka
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Correspondence to Rei Wake.

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Wake, R., Miyaoka, T., Araki, T. et al. Regional cerebral blood flow in late-onset schizophrenia: a SPECT study using 99mTc-ECD. Eur Arch Psychiatry Clin Neurosci 266, 3–12 (2016). https://doi.org/10.1007/s00406-015-0607-z

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  • DOI: https://doi.org/10.1007/s00406-015-0607-z

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