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The effect of vestibular rehabilitation in Meniere’s disease: a systematic review and meta-analysis of clinical trials

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Abstract

Background

Meniere’s disease (MD) is a complex disease that can severely affect the quality of life. In this systematic review and meta-analysis, we aimed to investigate the effect of vestibular rehabilitation (VR) versus control/other interventions on the quality of life in patients with MD.

Methods

We searched six electronic databases (PubMed/MEDLINE, Web of Science, EMBASE, Scopus, ProQuest, CENTRAL) from inception to September 30, 2022 with no language restriction for publications comparing the effect of VR with control/ other interventions in patients with MD. The primary outcome was quality of life assessed by dizziness handicap inventory (DHI).

Results

Overall, three studies with a total of 465 patients were included in the meta-analysis. All the included studies reported immediate-term DHI scores. A medium effect (standardized mean difference [SMD] = − 0.58, 95% confidence interval [CI] − 1.12; − 0.05) was observed favoring the use of VR to improve DHI scores in patients with MD in the immediate term. Moreover, there was severe heterogeneity in immediate DHI scores among the included studies (χ2 = 22.33, P = 0.00, I2 = 82.1%).

Conclusions

VR rehabilitation can improve the quality of life in patients with MD immediately after treatment. Since all the included studies had a high risk of bias and none had long-term follow-ups, further high-quality research is required to determine the short-, intermediate-, and long-term effects of VR compared to control/other interventions.

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Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

We sincerely appreciate the dedicated efforts of the personnel at the Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran.

Funding

The current study received no funding.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

    Ahmad Rezaeian, Hamidreza Abtahi & Mohammadreza Moradi

  2. Department of Community and Family Medicine, School of Medicine, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran

    Ziba Farajzadegan

Authors
  1. Ahmad Rezaeian
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  2. Hamidreza Abtahi
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  3. Mohammadreza Moradi
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  4. Ziba Farajzadegan
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Contributions

Conceptualization and study validation: AR. Implementation and supervision: HA. Data analysis and interpretation: ZF. Writing and reviewing: MM.

Corresponding author

Correspondence to Mohammadreza Moradi.

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The authors declare that they have no competing interests.

Ethics approval and consent to participate

The study received ethics approval from the Ethics Committee of Isfahan University of Medical Sciences under the ethics code.

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Rezaeian, A., Abtahi, H., Moradi, M. et al. The effect of vestibular rehabilitation in Meniere’s disease: a systematic review and meta-analysis of clinical trials. Eur Arch Otorhinolaryngol 280, 3967–3975 (2023). https://doi.org/10.1007/s00405-023-08066-x

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  • DOI: https://doi.org/10.1007/s00405-023-08066-x

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