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The association between metabolic syndrome and the prognosis of idiopathic sudden sensorineural hearing loss

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Abstract

Introduction

In this study, we investigated the association between metabolic syndrome and the prognosis of idiopathic sudden sensorineural hearing loss.

Methods

In this prospective cohort study, 79 patients with idiopathic SSNHL admitted to the ENT ward were involved. Patients were under treatment with two-dose pulse methylprednisolone and then oral corticosteroid (Prednisolone 1 mg/kg for up to 2 weeks and more). In all patients, the mean hearing threshold was measured before treatment and 3 weeks after the treatment. Metabolic syndrome criteria were assessed in all patients too. Then, based on these diagnostic criteria all data in patients with and without metabolic were compared.

Results

There was a significant difference in Hypertension, BMI > 25, high TG and low HDL (p.v = 0.001) between two groups (metabolic syndrome group and non-metabolic syndrome group). The rate of recovered patients was significantly lower in the metabolic syndrome group than in the non-metabolic syndrome group (p.v = 0.001). It was found that metabolic syndrome (OR = 2.02), diabetes mellitus (OR = 7.32), HTN (OR = 4.09), BMI > 25 (OR = 3.24) and high initial hearing threshold (OR = 3.96) were clearly related to the poor prognosis of treatment.

Conclusions

According to the findings of this study, it was found that metabolic syndrome had a negative effect on hearing improvement in patients with idiopathic SSNHL.

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References

  1. Chien C-Y, Tai S-Y, Wang L-F, Hsi E, Chang N-C, Wu M-T et al (2015) Metabolic syndrome increases the risk of sudden sensorineural hearing loss in Taiwan: a case-control study. Otolaryngol-Head and Neck Surg 153(1):105–111

    Article  Google Scholar 

  2. Zedan AM (2019) Sudden sensorineural hearing loss in adults. BMJ 364:l755. https://doi.org/10.1136/bmj.l755

  3. Zhang Y, Jiang Q, Wu X, Xie S, Feng Y, Sun H (2019) The influence of metabolic syndrome on the prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 40(8):994–997

    Article  Google Scholar 

  4. Zhou Y, Qiu S, Liu D (2019) Impact of metabolic syndrome on recovery of idiopathic sudden sensorineural hearing loss. Am J Otolaryngol 40(4):573–576

    Article  Google Scholar 

  5. Zhang X, Weng Y, Xu Y, Xiong H, Liang M, Zheng Y, Ou Y (2019) Selected blood inflammatory and metabolic parameters predicted successive bilateral sudden sensorineural hearing loss. Dis Markers 2019:7165257. https://doi.org/10.1155/2019/7165257

  6. Singh A, Irugu DVK (2020) Sudden sensorineural hearing loss–A contemporary review of management issues. Journal of Otology 15(2):67–73

    Article  Google Scholar 

  7. Swarup S, Goyal A, Grigorova Y, Zeltser R (2021) Metabolic syndrome. StatPearls [internet]. StatPearls Publishing

    Google Scholar 

  8. Jung SY, Shim HS, Hah YM, Kim SH, Yeo SG (2018) Association of metabolic syndrome with sudden sensorineural hearing loss. JAMA Otolaryngol-Head Neck Surg 144(4):308–314

    Article  Google Scholar 

  9. Lin CF, Lee KJ, Yu SS, Lin YS (2016) Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss. Laryngoscope 126(1):142–149

    Article  CAS  Google Scholar 

  10. Mosnier I, Stepanian A, Baron G, Bodenez C, Robier A, Meyer B et al (2011) Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurotol 16(1):55–66

    Article  Google Scholar 

  11. Lin S-W, Lin Y-S, Weng S-F, Chou C-W (2012) Risk of developing sudden sensorineural hearing loss in diabetic patients: a population-based cohort study. Otol Neurotol 33(9):1482–1488

    Article  Google Scholar 

  12. Hwang JH, Hsu CJ, Liu TC, Yang WS (2011) Association of plasma adiponectin levels with hearing thresholds in adults. Clin Endocrinol 75(5):614–620

    Article  CAS  Google Scholar 

  13. Hwang J-H (2015) Role of obesity on the prognosis of sudden sensorineural hearing loss in adults. Otolaryngol-Head Neck Surg 153(2):251–256

    Article  Google Scholar 

  14. Rosmond R (2002) The glucocorticoid receptor gene and its association to metabolic syndrome. Obes Res 10(10):1078–1086

    Article  CAS  Google Scholar 

  15. Whorwood CB, Donovan SJ, Flanagan D, Phillips DI, Byrne CD (2002) Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome. Diabetes 51(4):1066–1075

    Article  CAS  Google Scholar 

  16. Savas M, Wester VL, Van Der Voorn B, Iyer AM, Koper JW, Van Den Akker EL et al (2021) Anthropometrics and metabolic syndrome in relation to glucocorticoid receptor polymorphisms in corticosteroid users. Neuroendocrinology 111(11):1121–1129

    Article  CAS  Google Scholar 

  17. Xie S, Qiang Q, Mei L, He C, Feng Y, Sun H et al (2018) Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss treated with adjuvant hyperbaric oxygen therapy. Eur Arch Otorhinolaryngol 275(1):47–51

    Article  Google Scholar 

  18. Jo S-Y, Lee S, Eom T-H, Jeun E-S, Cho H-H, Cho Y-B (2015) Outcomes of severe to profound idiopathic sudden sensorineural hearing loss. Clin Exp Otorhinolaryngol 8(3):206–210

    Article  Google Scholar 

  19. Otolaryngology-Head J (2018) Individual Sign In. JAMA 144(11):957

    Google Scholar 

  20. Bai X, Chen S, Xu K, Jin Y, Niu X, Xie L et al (2021) N-Acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss and attenuates hair cell death caused by ROS stress. Front Cell Dev Biol 9:659486

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Vahid Zand, Mohammadhossein Dadgarnia, Mohammadhossein Baradaranfar, Mojtaba Meybodian, Sedighe Vaziribozorg & Malihe Fazilati

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  1. Vahid Zand
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  2. Mohammadhossein Dadgarnia
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  3. Mohammadhossein Baradaranfar
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  4. Mojtaba Meybodian
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  5. Sedighe Vaziribozorg
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  6. Malihe Fazilati
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Corresponding author

Correspondence to Malihe Fazilati.

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The authors have no conflicts of interest.

Ethical approval

Study protocol was in accordance with the latest Declaration of Helsinki for medical research involving human subjects and was approved by the local ethics committee.

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Informed consent was obtained from all participants of the study.

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Zand, V., Dadgarnia, M., Baradaranfar, M. et al. The association between metabolic syndrome and the prognosis of idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 280, 1411–1415 (2023). https://doi.org/10.1007/s00405-022-07686-z

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  • DOI: https://doi.org/10.1007/s00405-022-07686-z

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