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Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

The serum galactomannan test has been used for diagnosing acute invasive fungal sinusitis (AIFS), especially invasive Aspergillus. We aimed to assess the accuracy of the test to diagnose acute invasive Aspergillus sinusitis (AIAS).

Methods

We searched all relevant articles published in PubMed, Embase, the Cochrane Library, and Web of Science databases up until September 14, 2020. The available data for serum galactomannan test to diagnose AIAS from selected studies were assessed. The diagnostic odds ratio (DOR), summary receiver operating characteristics (SROC), sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were estimated. Additionally, we analysed four studies with a cut-off value of 0.5.

Results

Five eligible articles were selected in this study. The total number of enrolled patients was 118, and 62 patients had confirmed AIAS. Among these 62 patients, the summary estimates of the serum galactomannan assay were as follows: DOR, 3.37 (95% confidence interval [CI]: 1.47–6.66); sensitivity, 0.63 (95% CI 0.50–0.74); specificity, 0.65 (95% CI 0.51–0.76); PLR, 1.83 (95% CI 1.21–2.74); NLR, 0.58 (95% CI 0.39–0.83). The SROC was 0.68.

Conclusion

In this current meta-analysis, the serum galactomannan test was classified as less accurate for purposes of diagnosing confirmed AIAS. These results suggest that the initial diagnosis of AIAS should not solely be dependent upon serum galactomannan test results. More studies of the test are needed in patients with AIAS to more accurately assess its diagnostic value.

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Availability of data and materials

The data used in this study is available in the assessed articles.

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Acknowledgements

There is nothing to declare.

Funding

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (NRF-2018R1D1A1A02049236). The work was supported by a National Research Foundation of Korea (NRF) Grant, funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF), funded by the Ministry of Science, ICT and Future Planning (NRF-2016M3A9D5A01952414). This study was supported by a Faculty Research Grant of Yonsei University College of Medicine (6-2018-0167).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Jeju National University College of Medicine, Jeju, Korea

    Suk Won Chang

  2. Department of Otorhinolaryngology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, Korea

    Suk Won Chang, Jae Sung Nam, Jong-Gyun Ha, Wasan F. Almarzouq, Chang-Hoon Kim, Joo-Heon Yoon & Hyung-Ju Cho

  3. Yonsei University Medical Library, Seoul, Korea

    Na Won Kim

  4. The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Korea

    Chang-Hoon Kim, Joo-Heon Yoon & Hyung-Ju Cho

  5. Otolaryngology-Head and Neck Surgery, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Wasan F. Almarzouq

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  1. Suk Won Chang
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Contributions

Conceptualization: SWC, HJC. Data curation: SWC, NWK, JGH. Formal analysis: SWC, JSN, JGH. Funding acquisition: CHK, JHY, HJC. Methodology: WFA, CHK. Project administration: SWC, WFA. Visualization: SWC, JGH, JSN. Writing—original draft: SWC. Writing—review and editing: CHK, JHY, HJC.

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Correspondence to Hyung-Ju Cho.

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Chang, S.W., Nam, J.S., Ha, JG. et al. Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis. Eur Arch Otorhinolaryngol 279, 793–800 (2022). https://doi.org/10.1007/s00405-021-06857-8

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