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Detection and staging of recurrent or metastatic nasopharyngeal carcinoma in the era of FDG PET/MR

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Abstract

Purpose

The aim of this pilot study was to evaluate the accuracy of 18 fluorodeoxyglucose (FDG) PET/MR imaging in detection and staging of recurrent or metastatic NPC.

Patients and methods

The PET/MR scans of 60 patients with clinically diagnosed recurrent or metastatic NPC between April 2017 and November 2019 were included in this study. Findings were evaluated according to the eighth edition of the American Joint Committee on Cancer staging system. Final diagnosis was confirmed at biopsy or imaging follow-up for at least 6 months.

Results

Of the 60 patients, 25, 26 and 42 had developed local lesions, regional nodal metastases and distant metastases, respectively. The overall accuracy of PET/MR imaging for staging of recurrent or metastatic NPC was 88.3%.

Conclusions

For recurrent or metastatic NPC, 18 FDG PET/MRI might serve as a single-step staging modality.

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Funding

This work was supported by a grant from the Natural Science Foundation of Zhejiang Province (no. LGF19H160007, LGF20H160007).

Author information

Author notes

  1. Yongfeng Piao and Caineng Cao contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Beijing, China

    Yongfeng Piao, Caineng Cao, Shuang Huang, Feng Jiang, Ting Jin, Qifeng Jin, Yonghong Hua, Qiaoying Hu & Xiaozhong Chen

  2. Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province, No 1, East Banshan Road, Gongshu District, Hangzhou, 310022, China

    Yongfeng Piao, Caineng Cao, Shuang Huang, Feng Jiang, Ting Jin, Qifeng Jin, Yonghong Hua, Qiaoying Hu & Xiaozhong Chen

  3. Hangzhou Universal Medical Imagine Diagnostion Center, Hangzhou, Zhejiang, China

    Yuanfan Xu

Authors
  1. Yongfeng Piao
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  2. Caineng Cao
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  3. Yuanfan Xu
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  4. Shuang Huang
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  5. Feng Jiang
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  10. Xiaozhong Chen
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Corresponding author

Correspondence to Xiaozhong Chen.

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Conflict of interest

Conflict of interest relevant to this article was not reported.

Ethical approval

This study was approved by the Institutional Review Board of Zhejiang Cancer Hospital (no. IRB-2020-46) with a waiver of informed consent and performed in accordance with the principles of the Declaration of Helsinki.

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Piao, Y., Cao, C., Xu, Y. et al. Detection and staging of recurrent or metastatic nasopharyngeal carcinoma in the era of FDG PET/MR. Eur Arch Otorhinolaryngol 279, 353–359 (2022). https://doi.org/10.1007/s00405-021-06779-5

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  • DOI: https://doi.org/10.1007/s00405-021-06779-5

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