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Hematologic parameters as predictive markers in pediatric Bell’s palsy

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Abstract

Purpose

To analyze various hematological parameters in pediatric population with Bell’s palsy (BP) and to determine the most valuable parameter as a prognostic marker.

Methods

Fifty-nine patients with BP under 18 years were enrolled, and patients were divided into three groups: recovery group (49 cases), non-recovery group (10 cases) and controls (65 healthy children). Age, white blood cell (WBC), hemoglobin (Hbg), mean platelet volume (MPV), red cell distribution width (RDW), neutrophil–lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein-to-albumin ratio (CAR) were determined and compared between groups. Additionally, the receiver operating characteristics (ROC) analysis was carried out, and the most valuable marker to demonstrate the prognosis among these parameters was investigated.

Results

While mean age was found as 10.69 ± 5.76 years, 28 (47.5%) female and 31 (52.5%) male pediatric patients were determined to be followed up due to BP in our hospital. When such parameters age, mean Hbg, MPV and RDW were examined, no significant difference was detected between groups. However, compared controls with recovery and non-recovery groups, WBC, NLR, PLR and CAR were found to be significantly higher, respectively (p < 0.05). Median CAR and NLR values were found to be significantly higher in non-recovery group, compared to those in recovery group (p = 0.001, p = 0.012, respectively). However, when median WBC and PLR were examined between recovery and non-recovery groups, no significant difference was observed (p > 0.05).

Conclusion

High NLR and CAR values in pediatric BP may be related to poor prognosis in such patients. CAR, however, is a more valuable parameter than NLR in terms of indicating poor prognosis.

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Funding

The authors declared that this study has received no financial support.

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Authors and Affiliations

  1. Department of Ear Nose and Throat and Head and Neck Surgery, Aksaray Education and Research Hospital, Aksaray University, 68100, Aksaray, Turkey

    Serkan Cayir

  2. Department of Pediatrics, Aksaray University, Aksaray, Turkey

    Cengizhan Kilicaslan

Authors
  1. Serkan Cayir
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  2. Cengizhan Kilicaslan
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Contributions

SC: collected and analyzed data, wrote article, approved the final version. CK: designed and supervised study, interpreted data, made statistics, wrote and revised article, approved the final version. SC, CK: collected and analyzed data, revised article, approved the final version.

Corresponding author

Correspondence to Serkan Cayir.

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Conflict of interest

The authors have no conflict of interest to declare.

Ethical approval

The Ethic Committee at Faculty of Medicine, Aksaray University approved the study protocol. The reference number of the study approval was REC 2020/06-60. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/ or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Cayir, S., Kilicaslan, C. Hematologic parameters as predictive markers in pediatric Bell’s palsy. Eur Arch Otorhinolaryngol 278, 1265–1269 (2021). https://doi.org/10.1007/s00405-020-06459-w

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