Abstract
Purpose
The objectives of this study were (1) to systematically review current definitions of head and neck squamous cell carcinoma (HNSCC) recurrence and (2) to propose a definition of locally recurrent HNSCC.
Methods
A systematic literature review was performed according to the ‘Preferred Reporting Items for Systematic Reviews and Meta-Analyses’ statement in Medline, Embase, and Cochrane databases guided by the study question “What is the definition of local recurrence for patients with HN:SCC?”. All retrieved studies were reviewed and qualitatively analyzed.
Results
The systematic literature search resulted in 3467 publications after removal of duplicates. Forty studies were examined as full text, and a total of five were found suitable for inclusion. All five included studies dealt with definitions of second primary HNSCC and were based on the Warren and Gates Criteria; (1) each of the tumors are malignant, (2) each must be distinct, and (3) the probability of one being a metastasis of the other must be excluded. Each of the included studies added specific anatomical and/or temporal separation measures to the criteria of second primary HNSCC. We propose the definition of locally recurrent HNSCC to be: (1) Same anatomical subsite or adjacent subsite within 3 cm of the primary lesion, (2) time-interval no more than 3 years (from completed treatment of the primary lesion), and (3) same p16-status for oropharyngeal carcinomas.
Conclusions
No uniform definition of locally recurrent HNSCC currently exists. We propose the Odense–Birmingham definition based on the anatomical subsite combined with a specific measurable distance and a temporal separation of three years.
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Dr. Pareek reports the following disclosures: Speaker’s Fee: AstraZeneca, Bayer, Boehringer Ingelheim; Advisory Board: AstraZeneca.
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Rohde, M., Rosenberg, T., Pareek, M. et al. Definition of locally recurrent head and neck squamous cell carcinoma: a systematic review and proposal for the Odense–Birmingham definition. Eur Arch Otorhinolaryngol 277, 1593–1599 (2020). https://doi.org/10.1007/s00405-020-05953-5
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DOI: https://doi.org/10.1007/s00405-020-05953-5