Abstract
Locally advanced oral cancers extending to infratemporal fossa (ITF) are a challenge to head and neck surgeons. These tumors are classified as T4b whenever the masticator space (MS), pterygoid muscles (PM), and pterygoid plates (PP) are involved according to AJCC classification. Until recently, these tumors were considered inoperable and treated only with palliative intent. However, a few studies in the last decade showed that many of these tumors could be resected with a reasonably favorable prognosis by compartment resection of ITF, particularly when the tumor was below sigmoid notch of mandible. A few studies attempted to downstage these tumors by neo-adjuvant chemotherapy before attempting resection. Oral Squamous cell carcinoma has a high prevalence in South India. Majority of these patients are females addicted to tobacco quid chewing and present with locally advanced disease. In this retrospective analysis, we evaluated the outcome of treatment of oral squamous cell carcinoma extending to ITF and staged T4b in 52 patients. All patients underwent Composite resection including compartment resection of ITF followed by adjuvant treatment. 20 patients had received neo-adjuvant chemotherapy. Pectoralis major myocutaneous flap was the mainstay of reconstruction. After mean follow-up of 2 years, 31 patients are alive and disease free. 14 patients had local recurrence in ITF and 2 patients had recurred in cervical nodes. 8 patients died due to disease and 6 are on palliative care. Neo-adjuvant chemotherapy did not benefit the outcome. Close margins of resection, extra nodal spread from lymph nodes and supra notch and involvement of posterior part of ITF were factors which predisposed to recurrence.
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References
Liao CT, Chang JT, Wang HM et al (2006) Surgical outcome of T4a and resected T4b oral cavity cancer. Cancer 107:337–340
Liao CT, Ng SH, Chang JT (2007) T4b oral cavity cancer below the mandibular notch is resectable with a favorable outcome. Oral Oncol 43:570–579
Ota Y (2017) Infratemporal surgery for oral cancer invaded to masticator space. Int J Oral Maxillofac Surg 46(1):372–373
Trivedi NP, Kekatpure V, Kuriakose MA. Radical (compartment) resection for advanced buccal cancer involving masticator space (T4b): our experience in thirty patients. Clinical Otolaryngology 37: 470–496
Trivedi NP, Kekatpure VD, Shetkar G, Gangoli A, Kuriakose MA (2015) Pathology of advanced buccal mucosa cancer involving masticator space (T4b). Indian J Cancer 52:611–615
Bang BA, Pattatheyil A, Sharan R, Chatterjee S (2014) Infratemporal fossa clearance for oral squamous cancer: Is it time to shift the paradigm. J Clin Oncol 32:(15_suppl):e17047–e17047
Nanda MS, Mohiyuddin SMA (2015) Neoadjuvant chemotherapy: role in locoregionally advanced oral cancers. Int J Med Sci Public Health 4(6):745–750 (cited May 02, 2016)
Shah JP, Cendon RA, Farr HW, Strong EW (1976) Carcinoma of the oral cavity. Factors affecting treatment failure at the primary site and neck. Am J Surg 132:504–507
Mohiyuddin SMA, Padiyar BV, Suresh TN, Mohammadi K, Sagayaraj A, Merchant S, Mahnaaz SA (2016) Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa. World J Otorhinolaryngol Head Neck Surg 2:17–21
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Mohiyuddin, S.M.A., Harsha, P., Maruvala, S. et al. Outcome of compartment resection of locally advanced oral cancers extending to infratemporal fossa: a tertiary rural hospital experience. Eur Arch Otorhinolaryngol 275, 2843–2850 (2018). https://doi.org/10.1007/s00405-018-5124-z
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DOI: https://doi.org/10.1007/s00405-018-5124-z