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Evaluation of endolymphatic hydrops using 3-T MRI after intravenous gadolinium injection

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Aim of this work is to establish evaluation criteria for identifying endolymphatic hydrops in the vestibule and cochlea using a magnetic resonance imaging (MRI) scanner. This is a retrospective diagnostic study. We evaluated 70 ears of 35 unilateral Ménière’s disease patients. We performed 3-T MRI 4 h after intravenous gadolinium injection. Otologists manually traced the outline of vestibule, cochlea, and endolymphatic space of the vestibule and cochlea on two-dimensional fluid-attenuated inversion-recovery (2D-FLAIR) images. The traced area was measured, and rates of endolymphatic space to the vestibule and cochlea were calculated. The same otologists judged whether the low signal intensity area of the cochlea was at the edge of the cochlea. For measuring the rate of endolymphatic space to the vestibule, when the cut-off value was 30%, the presence of endolymphatic hydrops was determined with sensitivity of 87.1% and specificity of 94.3%. In contrast, the rate of endolymphatic space to the cochlea produced low accuracy. Therefore, when the presence of endolymphatic hydrops in the cochlea was judged by whether the low signal intensity area in the cochlea was at the edge of cochlea, endolymphatic hydrops could be detected with sensitivity of 91.4% and specificity of 94.3%. We were able to identify endolymphatic hydrops in the vestibule when the rate of endolymphatic space to the vestibule was greater than 30%, and could detect endolymphatic hydrops in the cochlea when a low signal intensity area was located at the edge of the cochlea in 2D-FLAIR images.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant (nos. 16H06957, 17K11327) and a Grant-in-Aid from the Japan Agency for Medical Research and Development. The ethics committee of Osaka University Hospital approved the study (nos. 08223, 11341).

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Authors and Affiliations

  1. Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan

    Takao Imai, Tomoko Okumura, Yumi Ohta, Takashi Sato, Yoshiyuki Ozono, Yukiko Hanada, Ryusuke Imai, Kazuya Ohata & Hidenori Inohara

  2. Department of Otorhinolaryngology - Head and Neck Surgery, Osaka General Medical Center, Osaka, Japan

    Atsuhiko Uno

  3. Department of Otorhinolaryngology - Head and Neck Surgery, Nara Medical University, Nara, Japan

    Tadashi Kitahara

  4. Department of Otorhinolaryngology - Head and Neck Surgery, Niigata University Graduate School of Medicine and Dentistry, Niigata, Japan

    Arata Horii

  5. Department of Otolaryngology, Osaka City General Hospital, Osaka, Japan

    Suzuyo Okazaki

  6. Department of Otorhinolaryngology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    Takefumi Kamakura

  7. Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Osaka, Japan

    Yoshiyuki Watanabe

Authors
  1. Takao Imai
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  2. Atsuhiko Uno
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  3. Tadashi Kitahara
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  4. Tomoko Okumura
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  5. Arata Horii
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  6. Yumi Ohta
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  7. Takashi Sato
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  8. Suzuyo Okazaki
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  9. Takefumi Kamakura
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  10. Yoshiyuki Ozono
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  11. Yoshiyuki Watanabe
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  12. Yukiko Hanada
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  13. Ryusuke Imai
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  14. Kazuya Ohata
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  15. Hidenori Inohara
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Corresponding author

Correspondence to Takao Imai.

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All authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Imai, T., Uno, A., Kitahara, T. et al. Evaluation of endolymphatic hydrops using 3-T MRI after intravenous gadolinium injection. Eur Arch Otorhinolaryngol 274, 4103–4111 (2017). https://doi.org/10.1007/s00405-017-4739-9

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  • DOI: https://doi.org/10.1007/s00405-017-4739-9

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