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Clinical and morphological aspects of adenocarcinomas of the intestinal type in the inner nose: a retrospective multicenter analysis

  • Rhinology
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Abstract

Clinical and histological parameters from 117 patients with wood dust-related sinonasal adenocarcinomas of intestinal type (ITAC) were analyzed and correlated with a follow-up period of 5 years at least. The rate of survival for 5 years was 53.1 % and for 10 years 30.2 %. Only 33 patients were free of disease. 74.2 % of patients with recurrences died in relation to ITAC. As expected, tumors of T4-category had the worst prognosis. The mucus content of a tumor was the most important histological parameter. Endonasal methods of surgery had no more positive survival rates after 5 years. An effect of radiotherapy has to be in discussion. The high incidence of tumor recurrences requires control examinations consistently.

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References

  1. Franchi A, Santucci M, Wenig BM; Tumours oft he nasal cavity and paranasal sinuses; Adenocarcinoma, Intestinal-type adenocarcinomas; World Health Organization Classification of Tumours (2005) Pathology and Genetics of Head and Neck Tumours, Lyon, pp 20–22

  2. Böör A, Jurkovic I, Dudríková K, Kavecanský V, Friedmann I (1996) Pathology in focus intestinal-type sinonasal adenocarcinoma: a sporadic case. J Laryngol Otol 110:805–810

    Article  PubMed  Google Scholar 

  3. Whiteside OJH, Corbridge RJ, Capper JWR (2010) Esme Hadfield (1921-92) and the Wycombe woodworkers. J Med Biogr 18:24–26

    Article  CAS  PubMed  Google Scholar 

  4. http://www.dguv.de/de/zahlen-und-Fakten/BK-Geschehen/index-jsp.15.3.2015

  5. Sobin LH, Gospodarowicz MK, Wittekind C (2009) TNM Classification of Malignant Tumours, 7th edn. Willy-Blackwell, Weinheim, pp 43–47

  6. Kleinsasser O, Schroeder HG (1988) Adenocarcinomas of the inner nose after exposure to wood dust. Arch Otorhinolaryngol 245:1–15

    Article  CAS  PubMed  Google Scholar 

  7. Donhuijsen K, Hattenberger S, Schroeder HG (2004) Sinunasale Carcinome nach Holzstaubbelastung. Der Pathologe 25(1):14–20

    Article  CAS  PubMed  Google Scholar 

  8. Mayr SI, Hafizovic K, Waldfahrer F, Iro H, Kütting B (2010) Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case-control study. Int Arch Occup Environ Health 83(6):631–638

    Article  PubMed  Google Scholar 

  9. Orvcidas LJ, Lewis JE, Weaver AL, Bagniewski SM, Olsen KD (2005) Adenocarcinoma of the nose and paranasal sinuses: a retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients. Head Neck 27(5):370–375

    Article  Google Scholar 

  10. Franchi A, Gallo O, Santucci M (1999) Clinical relevance of the histological classification of sinonasal intestinal-type adenocarcinomas. Hum Pathol 30(10):1140–1145

    Article  CAS  PubMed  Google Scholar 

  11. Tilson MP, Gallia GL, Bishop JA (2014) Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas. Head Neck Pathol 8:59–65

    Article  PubMed  Google Scholar 

  12. Kennedy MT, Jordan RCK, Berean KW (2004) Perez-Ordoñez; Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol 57:932–937

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Lee JT, Garg R, Brunworth J, Keschner D, Thompson LDR (2013) Sinonasal respiratory epithelial adenomatoid hamartomas: Series of 51 cases and literature review. Am J Rhinol Allergy 27:322–328

    Article  PubMed  Google Scholar 

  14. Llorente JL, Nuñez F, Rodrigo JP, Fernández León R, Alvarez C, Hermsen M, Suárez C (2008) Sinonasal adenocarcinomas: our experience. Acta Otorrinolaringol Esp 59:235–238

    Article  PubMed  Google Scholar 

  15. Tripodi D, Ferron C, Malard O, de Montreuil CB, Planche L, Sebille-Rivain V, Roedlich C, Quéméner S, Renaudin K, Longuenesse C, Verger C, Meflah K, Gratas C, Géraut C (2011) Relevance of both individual risk factors and occupational exposure in cancer survival studies: the example of intestinal type sinonasal adenocarcinoma. Laryngoscope 121(9):2011–2018

    PubMed  Google Scholar 

  16. Bernardo T, Ferreira E, Silva CJ, Monteiro E (2013) Sinonasal adenocarcinoma—experience of an oncology center. Int J Otol Head Neck Surg 2:13–16

    Google Scholar 

  17. El Ayoubi A, Poizat F, Garrel R, Costes V, Guerrier B, Essakalli L, Kzadri M, Crampette L (2009) Sinonasal adenocarcinomas reviewed. Prognostic value of WHO 2005 histological classification. Ann Otol Chir Cervicofac 126(4):175–181

    Article  Google Scholar 

  18. Veloso-Teles R, Ribeiro I, Castro-Silva J, Monteiro E (2015) Adenocarcinomas oft he sinonasal tract: a case series from an Oncology Centre in Northern Portugal. Eur Arch Otorhinolaryngol 272(8):1913–1921

    Article  CAS  PubMed  Google Scholar 

  19. Donhuijsen K, Kollecker I, Petersen P, Gaßler N, Schulze J, Schroeder HG (2016) Metastatic behavior of sinonasal adenocarcinoma oft he intestinal type (ITAC). Eur Arch Otorhinolaryngol 273:649–654

    Article  CAS  PubMed  Google Scholar 

  20. Franquemont DW, Fechner RE, Mills SE (1991) Histologic classification of sinonasal intestinal-type adenocarcinoma. Am Surg Pathol 15:275–368

    Google Scholar 

  21. Franchi A, Palomba A, Fondi C, Miligi L, Paglierani M, Pepi M, Santucci M (2011) Immunohistochemical investigation of tumorigenic pathways in sinonasal intestinal-type adenocarcinoma. A tissue microarray analyses of 62 cases. Histopathology 59(1):98–105

    Article  PubMed  Google Scholar 

  22. Nitsche U, Zimmermann A, Späth C, Müller T, Maak M, Schuster T, Slotta-Huspenina J, Käser SA, Michalski CW, Janssen KP, Friess H, Rosenberg R, Bader FG (2013) Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Am Surg 258(5):775–782

    Google Scholar 

  23. Langner C, Harbaum L, Pollheimer MJ, Kornprat P, Lindtner RA, Schlemmer A, Vieth M, Rehak P (2012) Mucinous differentiation in colorectal cancer—indicator of poor prognosis? Histopathology 60:1060–1072

    Article  PubMed  Google Scholar 

  24. Claus F, Boterberg T, Ost P et al (2002) Postoperative radiotherapy for adenocarcinoma of the ethmoid sinuses: treatment results for 47 patients. Int J Radiat Oncol Biol Phys 54:1089–1094

    Article  PubMed  Google Scholar 

  25. Lund VJ, Chrisholm EJ, Takes RP et al (2012) Evidence for treatment strategies in sinonasal adenocarcinoma. Head Neck 34:1168–1178

    Article  PubMed  Google Scholar 

  26. Resto VA, Krane JF, Faquin WC, Lin DT (2006) Immunohistochemical distinction of intestinal-type sinonasal adenocarcinoma from metastatic adenocarcinoma of intestinal origin. Ann Otol Rhinol Laryngol 115(1):59–64

    Article  PubMed  Google Scholar 

  27. Hanna E, DeMonte F, Ibrahim S et al (2009) Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg 135:1219–1224

    Article  PubMed  Google Scholar 

  28. Bhayani MK, Yilmaz T, Sweeney A, Calzada G, Roberts DB, Levine NB, DeMonte F, Hanna EY, Kupferman ME (2014) Sinonasal adenocarcinoma: a 16-year experience at a single institution. Head Neck 36:1490–1496

    PubMed  Google Scholar 

  29. Knegt PP, Ah-See KW, vd Velden LA, Kerrebijn J (2001) Adenocarcinoma oft he ethmoidal sinus complex: surgical debulking and topical fluorouracil may be the optimal treatment. Arch Otolaryngol Head Neck Surg 127(4):141–146

    Article  CAS  PubMed  Google Scholar 

  30. Almeyda R, Capper J (2008) Is surgical debridement and topical 5 fluorouracil the optimum treatment for woodworkers’ adenocarcinoma oft he ethmoid sinuses? A case-controlled study of a 20-year experience. Clin Otolaryngol 33(5):435–441

    Article  CAS  PubMed  Google Scholar 

  31. Chiu AG, Vijay R, Ramakrishnan VR, Suh JO (2001) Sinonasal tumors. Jaypee Brothers, Verlag, pp 120 ff

  32. Shah JP, Patel SG, Singh B (2012) Head and neck surgery and oncology. Elsevier Health Sciences, pp 113

  33. Lund VJ, Howard DJ, Wei WI (2014) Tumors oft he nose, sinuses, and nasopharynx. Thieme, Stuttgart, pp 137–150

    Google Scholar 

  34. Simpson CL, Garabrant DH, Fryzek J, Homa DM, Peters RK (1998) Wood-dust exposures and cancer oft he colon. Int J Occup Environ Health 4:179–183

    Article  CAS  PubMed  Google Scholar 

  35. Innos K, Rahu M, Rahu K et al (2000) Wood dust exposure and cancer incidence: a retrospective cohort study of furniture workers in Estonia. Am J Ind Med 37:501–511

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Pathology, Academic Hospital Braunschweig, Braunschweig, Germany

    K. Donhuijsen, I. Kollecker & N. Gaßler

  2. Institute of Special Pharmacotherapy, Helios-Clinic of Oncology, Duisburg, Germany

    P. Petersen

  3. Professional Trade Association for Wood and Metal, Munich, Germany

    J. Wolf

  4. ENT-Clinic, Academic Hospital Braunschweig, Braunschweig, Germany

    H.-G. Schroeder

Authors
  1. K. Donhuijsen
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  2. I. Kollecker
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  3. P. Petersen
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  4. N. Gaßler
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  5. J. Wolf
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  6. H.-G. Schroeder
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Correspondence to H.-G. Schroeder.

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Donhuijsen, K., Kollecker, I., Petersen, P. et al. Clinical and morphological aspects of adenocarcinomas of the intestinal type in the inner nose: a retrospective multicenter analysis. Eur Arch Otorhinolaryngol 273, 3207–3213 (2016). https://doi.org/10.1007/s00405-016-3987-4

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  • DOI: https://doi.org/10.1007/s00405-016-3987-4

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