Abstract
The purpose was to assess degree of permanent facial nerve dysfunction after surgery for recurrent pleomorphic adenoma (RPA) of the parotid gland, including variables that might influence re-operation outcomes. Nationwide retrospective longitudinal cohort study including a questionnaire survey of patients undergoing surgery for RPA. Of 219 living patients, 198 (92 %) responded and 127 (63 %) reported no facial dysfunction. Statistically significant associations were found between number of surgeries and permanent facial nerve dysfunction of all degrees (OR 1.43, 95 % CI 1.16–1.78, p = 0.001). A not significant tendency for females to be associated with worse outcome was found (p = 0.073). Risks of different degrees of paresis after the second–fourth surgeries were found (OR 1.86–2.19, p < 0.05). Our study demonstrates a significant correlation between number of surgeries for RPA of the parotid and severity of facial nerve paresis. This is important when informing and planning treatment of these patients.
Similar content being viewed by others
References
Eveson JW, Kusafuka K, Stenman G, Nagao T (2005) Pleomorphic adenoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) Pathology and genetics of head and neck tumours. World Health Organization Classification of tumours, pp 254–258
Zbären P, Stauffer E (2007) Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck 29:751–757
Henriksson G, Westrin KM, Carlsöö B, Silfverswärd C (1998) Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer 82:617–620
Bradley PJ (2001) Recurrent salivary gland pleomorphic adenoma: etiology, management, and results. Curr Opin Otolaryngol Head Neck Surg 9:100–108
Renehan A, Gleave EN, McGurk M (1996) An analysis of the treatment of 114 patients with recurrent pleomorphic adenomas of the parotid gland. Am J Surg 172:710–714
Zbären P, Tschumi I, Nuyens M, Stauffer E (2005) Recurrent pleomorphic adenoma of the parotid gland. Am J Surg 189:203–207
Mehle ME, Kraus DH, Wood BG, Benninger MS, Eliachar I, Levine HL et al (1993) Facial nerve morbidity following parotid surgery for benign disease: the cleveland clinic foundation experience. Laryngoscope 103:386–388
Wittekindt C, Streubel K, Arnold G, Stennert E, Guntinas-Lichius O (2007) Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck 29:822–828
Malard O, Wagner R, Joubert M, Delemazure A-S, Rio E, Durand N et al (2013) Prognostic factors for secondary recurrence of pleomorphic adenoma: a 20-year, retrospective study. J Laryngol Otol 127:902–907
Phillips PP, Olsen KD (1995) Recurrent pleomorphic adenoma of the parotid gland: report of 126 cases and a review of the literature. Ann Otol Rhinol Laryngol 104:100–104
Andreasen S, Therkildsen MH, Bjørndal K, Homøe P (2015) Pleomorphic adenoma of the parotid gland 1985–2010: a Danish nationwide study of incidence, recurrence rate, and malignant transformation. Head Neck. doi:10.1002/hed.24228
Kahn JB, Gliklich RE, Boyev KP, Stewart MG, Metson RB, McKenna MJ (2001) Validation of a patient-graded instrument for facial nerve paralysis: the FaCE scale. Laryngoscope 111:387–398
House JW (1983) Facial nerve grading systems. Laryngoscope 93:1056–1069
Li Y, Jiang H, Wang K, Feng G, Ding X, Zha Y et al (2013) Quality of life survey on patients with peripheral facial paralysis by using Chinese version of the FaCE scale. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 48:11–16
Marsk E, Hammarstedt-Nordenvall L, Engström M, Jonsson L, Hultcrantz M (2013) Validation of a Swedish version of the facial disability index (FDI) and the facial clinimetric evaluation (FaCE) scale. Acta Otolaryngol. Informa Healthcare Stockholm 133:662–669
Stennert E, Wittekindt C, Klussmann JP, Arnold G, Guntinas-Lichius O (2004) Recurrent pleomorphic adenoma of the parotid gland: a prospective histopathological and immunohistochemical study. Laryngoscope 114:158–163
Suh M-W, Hah JH, Kwon SK, Jung Y-H, Kwon T-K, Kim KH et al (2009) Clinical manifestations of recurrent parotid pleomorphic adenoma. Clin Exp Otorhinolaryngol 2:193–197
Riad MA, Abdel-Rahman H, Ezzat WF, Adly A, Dessouky O, Shehata M (2011) Variables related to recurrence of pleomorphic adenomas: outcome of parotid surgery in 182 cases. Laryngoscope 121:1467–1472
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None of the authors have any conflicts of interest or financial relationships with any sponsors. This study was primarily done as unfunded voluntary work.
Rights and permissions
About this article
Cite this article
Nøhr, A., Andreasen, S., Therkildsen, M.H. et al. Stationary facial nerve paresis after surgery for recurrent parotid pleomorphic adenoma: a follow-up study of 219 cases in Denmark in the period 1985–2012. Eur Arch Otorhinolaryngol 273, 3313–3319 (2016). https://doi.org/10.1007/s00405-016-3921-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-016-3921-9