Abstract
Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans. Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation. The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints. Forty patients were randomized after septoplasty to receive surfactant-containing saline solution (group 1) or saline without surfactant (group 2). At the postoperative 48th, 72th and 96th hours, pieces of splint samples were taken and prepared for scanning electron microscopic evaluation. Biofilm formation was observed in 3, 6 and 14 of 20 samples in group 1 (surfactant used) and 3, 14 and 20 of 20 samples in group 2 (control) at 48th, 72th and 96th hours, respectively. Biofilm formation incidences of groups at 48th hour were similar (p > 0.05), whereas it was significantly lower at group 1 regarding 72th and 96th hours (p < 0.05). Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future.
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References
Donlan RM, Costerton JW (2002) Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15(2):167–193
Stewart PS, Costerton JW (2000) Antibiotic resistance of bacteria in biofilms. Lancet 358:135–138
Soto SM (2013) Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence. 4(3):22–29
Sanderson AR, Leid JG, Hunsaker D (2006) Bacterial biofilms on the sinus mucosa of human subjects with chronic rhinosinusitis. Laryngoscope 116(7):1121–1126
Chole RA, Faddis BT (2002) Evidence for microbial biofilms in cholesteatomas. Arch Otolaryngol Head Neck Surg 128(10):1129–1133
Joshi RR, Nepal A, Chhetri ST, Bhandary S, Panta TB, Regmi D (2012) An evaluation of merocel and neosporin impregnated ribbon gauze packs in patients following nasal surgery: a prospective randomised trial. Health Renaissance 10:30–34
Caniello M, Passerotti GH, Goto EY, Voegels RL, Butugan O (2005) Antibiotics in septoplasty: is it necessary? Braz J Otorhinolaryngol 71(6):734–738
Winkler C, Hohlfeld JM (2013) Surfactant and allergic airway inflammation. Swiss Med Wkly 29(143):w131
Chole RA, Faddis BT (2002) Evidence for microbial biofilms in cholesteatomas. Arch Otolaryngol Head Neck Surg 128(10):112–133
Campbell JB, Watson MG, Shenoi PM (1987) The role of intranasal splints in the prevention of post-operative nasal adhesions. Laryngol Otol 1(11):1140–1143
Hajiioannou JK, Bizaki A, Fragiadakis G, Bourolias C, Spanakis I, Chlouverakis G et al (2007) Optimal time for nasal packing removal after septoplasty. A comparative study. Rhinology 45(1):68–71
Caniello M, Passerotti GH, Goto EY, Voegels RL, Butugan O (2005) Antibiotics in septoplasty: is it necessary? Braz J Otorhinolaryngol 71(6):734–738
Yilmaz MS, Guven M, Elicora SS, Kaymaz R (2013) An evaluation of biodegradable synthetic polyurethane foam in patients following septoplasty: a prospective randomized trial. Otolaryngol Head Neck Surg 148(1):140–144
Schmidlin PR, Müller P, Attin T, Wieland M, Hofer D, Guggenheim B (2013) Polyspecies biofilm formation on implant surfaces with different surface characteristics. J Appl Oral Sci 21(1):48–55
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This work was supported by a grant from Eskişehir Osmangazi University (Project No. 201341D04)
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San, T., Ertugay, O.C., Catli, T. et al. Effects of surfactant on biofilm formation on silicone nasal splints. Eur Arch Otorhinolaryngol 272, 345–349 (2015). https://doi.org/10.1007/s00405-014-3094-3
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DOI: https://doi.org/10.1007/s00405-014-3094-3