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Magnetic resonance imaging evaluation of foetal intracranial haemorrhage and the correlation with ultrasound findings and postnatal outcomes

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives

The aim of the study was to compare the magnetic resonance imaging (MRI) findings of intracranial haemorrhage (ICH) in the middle- and late trimesters and to explore the relationship between the MRI features of foetal ICH and postnatal outcomes.

Methods

This was a retrospective study which recruited foetal ICH diagnosed by MRI in one tertiary centre from 2015 to 2019. The prenatal and postnatal medical records were reviewed.

Results

Of 39 ICH cases, 82.1% (32) had germinal matrix intraventricular haemorrhage (GM-IVH), and 18.9% (7) were diagnosed with non-GM-IVH. The cerebellum, corpus callosum and subdural space were affected in 5, 1 and 1 non-GM-IVH cases, respectively. MRI confirmed possible ICH on sonogram in 10 cases (35.7%) and the remaining 19 added ICH diagnoses that were not obtained on initial ultrasound imaging. Pregnancy outcome data were available in 82.1% of (32) cases, of which 21 were terminated pregnancies, 1 was foetal demise and 10 were delivered. One neonate died after birth and one infant suffered from hearing loss. The remaining eight patients had favourable outcome.

Conclusion

In our study, evaluation of the relationship between MRI findings and outcomes remains challenging, depending on the timing of examination and the hematoma itself. MRI was an adjunct to US in diagnosing ICH in utero which helps to assess postnatal development.

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Abbreviations

ICH:

Intracranial haemorrhage

GM-IVH:

Germinal matrix intraventricular haemorrhage

MRI:

Magnetic resonance imaging

HASTE:

Half-Fourier single-shot turbo spin echo

DWI:

Diffusion-weighted imaging

US:

Ultrasound

VM:

Ventriculomegaly

GA:

Gestational age

GW:

Gestational week

TOP:

Termination of pregnancy

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Acknowledgements

This project is supported by Shanghai Natural Science Funding Project (no. 19ZR1407200).

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Author notes

  1. Tianping Wang, Jue Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People’s Republic of China

    Tianping Wang, Shulei Cai, Guofu Zhang & He Zhang

  2. Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People’s Republic of China

    Jue Wang & Xirong Xiao

  3. Department of Radiology, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

    Taotao Sun

  4. Department of Ultrasound, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People’s Republic of China

    Zhongpeng Fu

Authors
  1. Tianping Wang
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Contributions

Guarantor of integrity of the entire study: HZ, XX and GZ. Study concepts and design: HZ, XX and GZ. Literature research: TW, JW and SC. Clinical studies: SC, TS, ZF. Experimental studies/data analysis: JW, SC and GZ. Statistical analysis: JW. Manuscript preparation: TW, JW, SC and HZ. Manuscript editing: HZ, TS and JW.

Corresponding author

Correspondence to He Zhang.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Wang, T., Wang, J., Cai, S. et al. Magnetic resonance imaging evaluation of foetal intracranial haemorrhage and the correlation with ultrasound findings and postnatal outcomes. Arch Gynecol Obstet 305, 877–884 (2022). https://doi.org/10.1007/s00404-021-06210-8

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  • DOI: https://doi.org/10.1007/s00404-021-06210-8

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