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Ultrasound guided core needle biopsy prior to thermo ablative treatment of uterine tumors: first results

  • General Gynecology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

This study aimed at evaluating the diagnostic yield for core needle biopsies of uterine fibroids before laparoscopic radiofrequency volumetric thermal ablation (RFVTA) with the aim of sonographic imaging. This study was in the context of a randomized, prospective, single-center, longitudinal comparative study in which RFVTA and laparoscopic myomectomy for symptomatic uterine fibroids were compared.

Methods

All patients of the RFVTA-arm received a core needle biopsy under the guidance of an intraoperative laparoscopic ultrasound system. The Tissue samples were observed histologically.

Results

24 patients were included and received in the median 3.17 biopsies (range 2–7). 45.8% of the fibroids were intramural. In 92% uterine leiomyoma was detected, in 4% a cell rich leiomyoma and in 4% a smooth muscle tumor with uncertain malignant potential (STUMP). There were no complications caused by core needle biopsy.

Conclusions

Ultrasound guided core needle biopsy can be used to receive a histological result before treating uterine fibroids with thermo surgical methods like RFVTA.

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Author information

Authors and Affiliations

  1. Department of Women’s Health, Research Centre for Women’s Health, Calwerstr. 7, 72076, Tübingen, Germany

    Christina B. Walter, Andreas D. Hartkopf, Dorit Schoeller, Bernhard Kraemer, Felix Neis, Florin-Andrei Taran, Sara Y. Brucker & Markus Hahn

  2. Harvard Medical School, Newton Wellesley Hospital, 2014 Washington St, Newton, MA, 02458, USA

    Keith B. Isaacson

Authors
  1. Christina B. Walter
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  2. Andreas D. Hartkopf
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  3. Dorit Schoeller
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  4. Bernhard Kraemer
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  5. Felix Neis
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  6. Florin-Andrei Taran
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  7. Keith B. Isaacson
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  8. Sara Y. Brucker
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  9. Markus Hahn
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Contributions

CBW and ADH: study conception and design, data collection, management and analysis, manuscript writing. DS, BK and FN: data collection and management and manuscript editing. FAT and KBI: data interpretation and manuscript editing. SB and MH: study conception and design and manuscript editing. All authors approved the final version to be published and agreed to be accountable for all aspects of the work ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Sara Y. Brucker.

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Funding

None.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethic approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the ethic committee Tübingen on the 21th November 2012 (IRB File Number: 408/2012MPG23).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Walter, C.B., Hartkopf, A.D., Schoeller, D. et al. Ultrasound guided core needle biopsy prior to thermo ablative treatment of uterine tumors: first results. Arch Gynecol Obstet 297, 387–392 (2018). https://doi.org/10.1007/s00404-017-4590-7

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  • DOI: https://doi.org/10.1007/s00404-017-4590-7

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