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Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To compare the circulating levels of cathepsins B and D in preeclamptic and normotensive pregnancies.

Methods

Seventy-two pregnant patients were enrolled in this study. Of the 72 pregnant patients, 25 were preeclamptic and 47 patients were normotensive. Serum levels of soluble cathepsins B and D were measured with an enzyme-linked immunosorbent assay (ELISA) kit.

Results

Cathepsin B levels were significantly higher in preeclamptic women than normotensive pregnant women (125.9 vs. 41.9 ng/mL; p = 0.013). The serum levels of cathepsin D were lower in preeclamptic women, but the differences were not significant (129.3 vs. 200.9 ng/mL; p = 0.077). However, cathepsin B and D levels were not correlated with severity of preeclampsia and small for gestational age. The serum levels of cathepsin D were inversely correlated with uric acid in preeclamptic patients (r = −0.527; p = 0.03).

Conclusion

The serum levels of cathepsin B levels were increased significantly in preeclamptic women. Correlation with severity of preeclampsia needs further investigation to clarify the role of cathepsin B.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, KangDong Sacred Heart Hospital, Hallym University, #150 Seongnae-gil, Gangdong-gu, Seoul, 134-701, Republic of Korea

    Ho Yeon Kim & Bo Wook Kim

  2. Department of Internal Medicine, KangDong Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea

    Yoon Jung Kim

Authors
  1. Ho Yeon Kim
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  2. Bo Wook Kim
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Correspondence to Ho Yeon Kim.

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Funding

This study was funded by the Kang Dong Sacred Heart Hospital Research Fund (2014-02).

Conflict of interest

Author HY Kim declares that she has no conflict of interest. Author BW Kim declares that he has no conflict of interest. Author YJ Kim declares that she has no conflict of interest. The authors alone are responsible for the content and writing of the article. Authors do not have a financial relationship with the organization that sponsored the research. Authors have had full control of all primary data and agree to allow the Journal to review their data.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Kim, H.Y., Kim, B.W. & Kim, Y.J. Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia. Arch Gynecol Obstet 294, 1145–1150 (2016). https://doi.org/10.1007/s00404-016-4129-3

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  • DOI: https://doi.org/10.1007/s00404-016-4129-3

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