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Annexin A2 plays a critical role in epithelial ovarian cancer

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

This study aimed at investigating the potential role and prognostic significance of Annexin A2 in human epithelial ovarian cancer (EOC).

Methods

Western blot was used to evaluate the expression of Annexin A2 in nine fresh EOC tissues, and immunohistochemical analysis was performed on formalin-fixed paraffin-embedded sections of 119 cases of ovarian cancers. Then, we used Fisher exact test to analyze the correlation between Annexin A2 and clinicopathological parameters. Starvation refeeding was used to detect the alteration of Annexin A2 in HO8910 cell cycle.

Results

Annexin A2 was overexpressed in carcinoma tissues compared with normal tissue, and the expression levels gradually increased from G1 to G3. Moreover, the staining of tissue microarray was consistent with the result we got from western blot, increasing from G1 to G3 gradually, and it was related to the Figo stage (P = 0.005), histologic grade (P = 0.002), ascite (P < 0.001), malignant tumor cells (P < 0.001), residual tumor size (P = 0.044), Ki-67 (P = 0.003). Kaplan–Meier analysis revealed that high Annexin A2 expression was significantly associated with poor prognoses of the patients (P < 0.001). Multivariate analysis demonstrated that Annexin A2 was an independent prognostic indicator for overall survival. Starvation refeeding indicated that Annexin A2 was related to EOC cell proliferation.

Conclusions

We could hypothesize that Annexin A2 acted a critical role in EOC cell proliferation, and may be used as a potential and novel therapeutic target for EOC. These data suggest that Annexin A2 may promote the progression of EOC and be a therapeutic target for EOC therapy.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81302285).

Conflict of interest

The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

    Yan Deng, Chen Chen, Minhui Hua, Qinghua Xi, Jian Liu, Jianxin Zhong, Meilan Tang, Shumin Lu & Chunhui Tang

  2. Department of Pathogen Biology, Medical College, Jiangsu Province Key Laboratory for information and molecular Drug Target, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

    Yingying Wang

  3. Department of Pathology, Nantong University Cancer Hospital, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

    Rong Liu & Shuyun Yang

Authors
  1. Yan Deng
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  2. Chen Chen
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  3. Minhui Hua
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  4. Qinghua Xi
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  5. Rong Liu
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  7. Jian Liu
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  8. Jianxin Zhong
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  9. Meilan Tang
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  10. Shumin Lu
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  11. Chunhui Tang
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Corresponding authors

Correspondence to Chunhui Tang or Yingying Wang.

Additional information

Y. Deng and C. Chen contributed equally to this work.

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Deng, Y., Chen, C., Hua, M. et al. Annexin A2 plays a critical role in epithelial ovarian cancer. Arch Gynecol Obstet 292, 175–182 (2015). https://doi.org/10.1007/s00404-014-3598-5

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  • DOI: https://doi.org/10.1007/s00404-014-3598-5

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