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A potential association between psoriasin to rs4819554 of IL-17RA gene polymorphism in psoriasis Egyptian patients

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A Letter to the Editor to this article was published on 09 March 2020

Abstract

Interleukin 17 (IL-17) is one of the pro-inflammatory cytokine. Psoriasin is a noticeably over-expressed protein found in the skin lesions of psoriatic patients. Our current study was planned to examine the association of (− 947 A/G) single nucleotide polymorphism (SNP) in IL-17RA promoter region (rs4819554) with psoriasis susceptibility in Egyptian psoriatic patients. Our study included 100 patients and 100, age as well as sex matched, control groups. IL-17RA SNP association was studied using allelic discrimination. RT-qPCR and ELISA were done to assess IL-17 expression. ELISA was performed to assess psoriasin expression. Our study showed a significant association between IL-17 rs4819554 SNP and psoriasis risk, evidenced by higher G allele and AG genotype frequencies in psoriatic patients when compared to controls (allelic: OR 2.283, 95% CI 1.321–3.946, p = 0.003, and genotype: OR 3.026, 95% CI 1.356–6.752, p = 0.007). Additionally, serum psoriasin level was significantly increased when comparing psoriatic patients to controls (p = 0.0003). Moreover, significant increase in IL 17 gene and protein level in AA, AG psoriatic genotypes compared to the corresponding genotypes in normal control (p = 0.0004). IL-17 rs4819554 is significantly associated with psoriasis, and with psoriasin level, in the Egyptian population.

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Acknowledgements

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Authors and Affiliations

  1. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

    Dina Sabry & Mai Samir

  2. Dermatology Department, Faculty of Medicine, Fayoum University, Faiyum, Egypt

    Nesreen Aboraia

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  1. Dina Sabry
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Sabry, D., Aboraia, N. & Samir, M. A potential association between psoriasin to rs4819554 of IL-17RA gene polymorphism in psoriasis Egyptian patients. Arch Dermatol Res 312, 273–281 (2020). https://doi.org/10.1007/s00403-019-02011-x

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