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Staphylococcus aureus colonization and chronic hand eczema: a multicenter clinical trial

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Abstract

Chronic hand eczema is a common chronic inflammatory skin disease that influences public health. Staphylococcus aureus colonization plays important roles in chronic hand eczema morbidity and progression, which also correlated to chronicity and severity of the disease. In this multicenter clinical trial, we aim to investigate the relationship between S. aureus colonization and chronic hand eczema. Eighty patient volunteers diagnosed with chronic hand eczema in 4 hospitals from 4 cities participated in this study. Staphylococcus aureus colonization was determined using Polymerase Chain Reaction and fluorescent labeling probe to rapidly detect the endemic thermostable nuclease gene nuc of S. aureus in clinical samples. All patients were treated with Halometasone Triclosan Cream for 2 weeks. The changes of clinical symptom scores were observed during the follow-up time. We found that the severity of chronic hand eczema was related to S. aureus colonization. Chronic hand eczema would remain severer than others if S. aureus colonization was not eliminated. Eliminating S. aureus colonization could provide good effectiveness in treatment of chronic hand eczema. Therefore, we make a proposal that detection and treatment of S. aureus should be considered in the clinical treatment of chronic hand eczema.

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Abbreviations

CHE:

Chronic hand eczema

SA:

Staphylococcus aureus

HECSI:

Hand Eczema Severity Index

HEES:

Hand Eczema Extent Score

IGA:

Investigator’s Global Assessment

DLQI:

Dermatology Life Quality Index

VAS:

Visual Analogue Scales

SSRI:

Symptom Score Reducing Index

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Acknowledgements

We thank all the dermatologists from Beijing Friendship Hospital Capital Medical University, Jiangsu Province Hospital, Shanghai General Hospital and Wuhan No. 1 Hospital those offer their help in this study. Funding and Halometasone Triclosan Cream of this work were supplied by Lansen Pharmaceutical Holdings Limited, Ningbo, China.

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Author notes

  1. Xin Wang, Wei Xu and Yue Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Shanghai, 200080, China

    Xin Wang, Chengzhong Zhang & Weimin Shi

  2. Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China

    Wei Xu & Linfeng Li

  3. Department of Dermatology, Shanghai General Hospital of Nanjing Medical University, 100 Haining Road, Shanghai, 200080, China

    Yue Chen

  4. Department of Dermatology, Wuhan No. 1 Hospital, 215 Zhongshan Road, Wuhan, 430022, China

    Liuqing Chen

  5. Department of Dermatology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China

    Yan Lu

Authors
  1. Xin Wang
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  2. Wei Xu
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  3. Yue Chen
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  4. Chengzhong Zhang
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  5. Liuqing Chen
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  6. Yan Lu
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  7. Weimin Shi
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  8. Linfeng Li
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Contributions

WS and LL designed the study; XW, WX, YC, CZ, LC and YL collected, analyzed, and interpreted the data; XW, WS and LL drafted the manuscript. All the authors critically read and approved the manuscript.

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Correspondence to Weimin Shi or Linfeng Li.

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Wang, X., Xu, W., Chen, Y. et al. Staphylococcus aureus colonization and chronic hand eczema: a multicenter clinical trial. Arch Dermatol Res 311, 513–518 (2019). https://doi.org/10.1007/s00403-019-01924-x

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  • DOI: https://doi.org/10.1007/s00403-019-01924-x

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