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Tilt table testing for syncope and collapse

Die Kipptischuntersuchung bei Synkope und Kollaps

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Abstract

Head-up tilt (HUT) has long been used to examine heart rate and blood pressure adaptation to changes in position. During such studies, incidental observations noted that some test subjects experienced total or near-total transient loss of consciousness and that, in some cases, hypotension was associated with unexpected marked bradycardia compatible with a vasovagal syncope (VVS) reaction. The first report of HUT as a clinical tool to confirm a diagnosis of suspected VVS was published in 1966, and led to the concept of using HUT as a diagnostic tool for VVS. Subsequently, HUT testing, either drug-free or, if necessary, with pharmacological provocation (usually nitroglycerin) has proven to be a useful and safe modality for identifying susceptibility to VVS. In this regard, it is recognized that VVS is best diagnosed by careful history taking. Unfortunately, the history may be non-diagnostic; HUT may be helpful in such cases. However, the interpretation of HUT requires care and experience; in particular, the outcome must be consistent with the patient’s clinical presentation. The reproduction of patient symptoms may not only provide a diagnosis, but also offer some comfort to the patient and family in that the medical team has documented the basis of symptoms and are thereby positioned to address therapy.

Zusammenfassung

Die Kipptischuntersuchung (KTU) wird seit Langem genutzt, um die Anpassung von Herzfrequenz und Blutdruck bei Lageänderungen zu prüfen. In entsprechenden Studien hat man beobachtet, dass manche Teilnehmer vollständig oder fast vollständig das Bewusstsein verloren und dass in manchen Fällen eine Hypotonie mit einer unerwartet ausgeprägten Bradykardie assoziiert war, passend zu einer vasovagalen Synkopen(VVS)-Reaktion. Der erste Bericht über die KTU als klinisches Instrument, mit dem sich die Diagnose einer vermuteten VVS sichern lässt, stammt aus dem Jahr 1966 und führte zu dem Plan, die KTU als diagnostisches Verfahren für die VVS zu nutzen. In der Folgezeit hat sich die KTU als hilfreiche und sichere Modalität zur Identifikation einer VVS-Neigung erwiesen – ohne medikamentöse Beeinflussung oder, wenn erforderlich, mit pharmakologischer Provokation (gewöhnlich mit Nitroglyzerin). In diesem Zusammenhang sei festgestellt, dass die VVS am besten auf Basis einer gründlichen Anamneseerhebung diagnostiziert wird. Allerdings führt die Anamnese nicht immer zur Diagnose; dann kann die KTU von Nutzen sein. Die Interpretation der KTU erfordert jedoch Sorgfalt und Erfahrung; nicht zuletzt muss das Ergebnis mit dem klinischen Bild des Patienten im Einklang stehen. Die gezielte Auslösung der Symptome führt nicht nur potenziell zu einer Diagnose, vielmehr kann sie beim Patienten und seinen Angehörigen auch für eine gewisse Beruhigung sorgen, weil nun der Ursprung der Symptome dokumentiert ist und die Therapie in Angriff genommen werden kann.

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References

  1. Kubo SH, Cody RJ (1983) Circulatory autoregulation in chronic congestive heart failure: responses to head-up tilt in 41 patients. Am J Cardiol 52(5):512–518

    Article  PubMed  CAS  Google Scholar 

  2. Grubb BP, Karas B (1999) Clinical disorders of the autonomic nervous system associated with orthostatic intolerance: an overview of classification, clinical evaluation, and management. Pacing Clin Electrophysiol 22:798–810

    Article  PubMed  CAS  Google Scholar 

  3. Allen SC, Taylor CL, Hall VE (1945) A study of orthostatic insufficiency ty the tiltboard method. Am J Physiol 143:11–18

    Google Scholar 

  4. McMicheal J, Sharpey Shafer EP (1944) Cardiac output in man by a direct Fick method: effect of posture, venous pressure change, atropine and adrenaline. Br Heart J 6:33–40

    Article  Google Scholar 

  5. Sharpey Shafer EP (1956) Syncope. Br Med J 1:506–509

    Article  Google Scholar 

  6. Davies R, Slater JDH, Forsling ML, Payne N (1976) The response of arginine vasopressin and plasma renin to postural change in normal man, with observations on syncope. Clin Sci 51:267–274

    Article  CAS  Google Scholar 

  7. Hammill SC, Holmes DR, Wood DL et al (1984) Electrographic testing in the upright position: improved evaluation of patients with rhythm disturbances using a tilt table. J Am Coll Cardiol 4:65–71

    Article  PubMed  CAS  Google Scholar 

  8. Maloney JD, Jaeger FJ, Fouad-Tarazi FM et al (1988) Malignant vasovagal syncope: prolonged asystole provoked by head-up tilt. Case report and review of diagnosis, pathophysiology, and therapy. Cleve Clin J Med 55:542–548

    Article  PubMed  CAS  Google Scholar 

  9. Kenny RA, Ingram A, Bayliss J, Sutton R (1986) Head-up tilt: a useful test for investigating unexplained syncope. Lancet 1:1352–1355

    Article  PubMed  CAS  Google Scholar 

  10. Moya A, Sutton R, Ammirati F et al (2009) Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J 21:2631–2671

    Google Scholar 

  11. Haines DE, Beheiry S, Akar JG, Baker JL, Beinborn D, Beshai JF, Brysiewicz N, Chiu-Man C, Collins KK, Dare M, Fetterly K, Fisher JD, Hongo R, Irefin S, Lopez J, Miller JM, Perry JC, Slotwiner DJ, Tomassoni GF, Weiss E (2014) Heart Rythm Society expert consensus statement on electrophysiology laboratory standards: process, protocols, equipment, personnel, and safety. Heart Rhythm 11:e9–51

    Article  PubMed  Google Scholar 

  12. Adamec I, Mismas A, Zaper D, Junakovic A, Hajnsek S, Habek M (2013) Short pain-provoked head-up tilt test for the confirmation of vasovagal syncope. Neurol Sci 34:869–873

    Article  PubMed  Google Scholar 

  13. Fitzpatrick AP, Theodorakis G, Vardas P, Sutton R (1991) Methodology of head-up tilt testing in patients with unexplained syncope. J Am Coll Cardiol 17:125–130

    Article  PubMed  CAS  Google Scholar 

  14. Almquist A, Goldenberg IF, Milstein S, Chen MY, Chen XC, Hansen R, Gornick CC, Benditt DG (1989) Provocation of bradycardia and hypotension by isoproterenol and upright posture in patients with unexplained syncope. N Engl J Med 320:346–351

    Article  PubMed  CAS  Google Scholar 

  15. Natale A, Akhtar M, Jazayeri M, Dhala A, Blanck Z, Deshpande S, Krebs A, Sra JS (1995) Provocation of hypotension during head-up tilt testing in subjects with no history of syncope or presyncope. Circulation 92:54–58

    Article  PubMed  CAS  Google Scholar 

  16. Waxman MB, Yao L, Cameron DA, Wald RW, Roseman J (1989) Isoproterenol induction of vasodepressor-type reaction in vasodepressor-prone persons. Am J Cardiol 63:58–65

    Article  PubMed  CAS  Google Scholar 

  17. Kapoor WN, Brant N (1992) Evaluation of syncope by upright tilt testing with isoproterenol. A nonspecific test. Ann Intern Med 116:358–363

    Article  PubMed  CAS  Google Scholar 

  18. Morillo CA, Klein GJ, Zandri S, Yee R (1995) Diagnostic accuracy of a low-dose isoproterenol head-up tilt protocol. Am Heart J 129:901–906

    Article  PubMed  CAS  Google Scholar 

  19. Heart Rhythm Society (2015) “Special notice regarding pricing of isoproterenol/isuprel”. Press release, April 8

    Google Scholar 

  20. Raviele A, Gasparini G, Di Pede F, Menozzi C, Brignole M, Dinelli M, Alboni P, Piccolo E (1994) Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. Am Heart J 127:103–111

    Article  PubMed  CAS  Google Scholar 

  21. Raviele A, Menozzi C, Brignole M, Gasparini G, Alboni P, Musso G, Lolli G, Oddone D, Dinelli M, Mureddu R (1995) Value of head-up tilt testing potentiated with sublingual nitroglycerin to assess the origin of unexplained syncope. Am J Cardiol 76:267–272

    Article  PubMed  CAS  Google Scholar 

  22. Forleo C, Guida P, Iacoviello M, Resta M, Monitillo F, Sorrentino S, Favale S (2013) Head-up tilt testing for diagnosing vasovagal syncope: a meta-analysis. Int J Cardiol 168:27–35

    Article  PubMed  Google Scholar 

  23. Connolly SJ, Sheldon R, Thorpe KE, Roberts RS, Ellenbogen KA, Wilkoff BL, Morillo C, Gent M, VPS II Investigators (2003) Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: second Vasovagal Pacemaker Study (VPS II): a randomized trial. JAMA 289:2224–2229

    Article  PubMed  Google Scholar 

  24. Raviele A, Giada F, Menozzi C, Speca G, Orazi S, Gasparini G, Sutton R, Brignole M, Vasovagal Syncope and Pacing Trial Investigators (2004) A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE). Eur Heart J 25(19):1741–1748

    Article  PubMed  Google Scholar 

  25. Brignole M, Menozzi C, Moya A, Andresen D, Blanc JJ, Krahn AD, Wieling W, Beiras X, Deharo JC, Russo V, Tomaino M, Sutton R (2012) Pacemaker therapy in patients with neurally-mediated syncope and documented asystole. Third international study on syncope of unknown etiology (ISSUE-3): a randomized trial. Circulation 125:2566–2571

    Article  PubMed  Google Scholar 

  26. Brignole M, Donateo P, Tomaino M, Massa R, Iori M, Beiras X, Moya A, Kus T, Deharo JC, Giuli S, Gentili A, Sutton R (2014) Benefit of pacemaker therapy in patients with presumed neurally-mediated syncope and documented asystole is greater when tilt test is negative. An analysis from the Third International Study on Syncope of Uncertain Etiology (ISSUE-3). Circ Arrhythm Electrophysiol 7:10–16

    Article  PubMed  Google Scholar 

  27. Brignole M, Arabia F, Ammirati F, Tomaino M, Quartieri F, Rafanelli M, Del Rosso A, Vecchi MR, Russo V, Gaggioli G, on behalf of the Syncope Unit Project 2 (SUP2) Investigators (2016) Standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncope: 3‑year insights from the Syncope Unit Project 2 (SUP2) study. Europace 18:1427–1433

    Article  PubMed  Google Scholar 

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Acknowledgements

D.G. Benditt is supported in part by a grant from the Dr. Earl E Bakken family in support of heart–brain research.

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Correspondence to David G. Benditt MD.

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R. Kohno, W.O. Adkisson, and D.G. Benditt declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Kohno, R., Adkisson, W.O. & Benditt, D.G. Tilt table testing for syncope and collapse. Herzschr Elektrophys 29, 187–192 (2018). https://doi.org/10.1007/s00399-018-0568-9

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