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Proteomics and transcriptomics in atrial fibrillation

Proteomik und Transkriptomik bei Vorhofflimmern

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Abstract

Atrial fibrillation (AF) is the most common tachyarrhythmia. AF, due to substantial remodeling processes initiated in the atria, is a typically self-sustaining and progressive disease. Atrial remodeling has been intensively investigated at the molecular level in recent decades. Although the application of “omics” technologies has already significantly contributed to our current understanding of the pathophysiology of AF, the complexity of the latter and the large heterogeneity of AF patients remained a major limitation. With the advent of novel “omics” and by applying integrative approaches, it will be possible to extract more information and push boundaries. The present review will summarize the contribution of transcriptomics and proteomics to our understanding of the pathophysiology of AF.

Zusammenfassung

Vorhofflimmern (AF) ist die häufigste Tachyarrhythmie in der klinischen Praxis. AF ist aufgrund von signifikanten atrialen Remodeling-Prozessen eine typischerweise selbsterhaltende und progrediente Erkrankung. Das atriale Remodeling wurde in den letzten Jahrzehnten intensiv auf molekularer Ebene untersucht. Obwohl die Anwendung von „Omics“-Technologien bereits wesentlich zu unserem derzeitigen Verständnis der Pathophysiologie von AF beigetragen hat, blieben die Komplexität der zugrundeliegenden molekularen Mechanismen und die große Heterogenität von AF-Patienten wesentliche Limitationen. Mit der jetzigen Verfügbarkeit von neuartigen „Omics“-Technologien und durch die Anwendung von integrativen Ansätzen wird es möglich sein, mehr Informationen zu extrahieren und bestehende Grenzen zu verschieben. Der vorliegende Review fasst den Beitrag der Transkriptomik und Proteomik zu unserem Verständnis der Pathophysiologie von AF zusammen.

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Acknowledgements

We thank Jörg Mostertz and Falco Hochgräfe for their great support in phosphoproteome analysis. We would like to apologize to all authors who could not be referred to due to space constraints.

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Authors and Affiliations

  1. Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Ernst Moritz Arndt University Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany

    Marc Sühling, Carmen Wolke & Uwe Lendeckel

  2. Department of Otorhinolaryngology, Head and Neck Surgery, University Medicine Greifswald, Ernst Moritz Arndt University Greifswald, Greifswald, Germany

    Christian Scharf

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  1. Marc Sühling
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Correspondence to Uwe Lendeckel.

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M. Sühling, C. Wolke, C. Scharf and U. Lendeckel declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Sühling, M., Wolke, C., Scharf, C. et al. Proteomics and transcriptomics in atrial fibrillation. Herzschr Elektrophys 29, 70–75 (2018). https://doi.org/10.1007/s00399-017-0551-x

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