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Design of Tween80/oleic acid composite vesicle and its application in controlled release of vitamin C

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Abstract

Fatty acid vesicles (FAVs), with their unique bionic structure, play a crucial role in models for protocells, food manufacturing, and drug delivery systems. However, FAVs are highly sensitive to changes in pH, which imposes strict constraints on their development in food and medicine. Therefore, in this study, the pH window of vesicles formed by oleic acid (OA) was migrated and expanded by introducing a nonionic surfactant, Tween80 (TW80), which resulted in a more stable pH environment for FAVs. Acid–base titration combined with particle size confirmed that different ratios of TW80 and OA expanded the pH window from 8.2–10 to 1.99–7.49, as determined by potential and turbidity. The intermolecular forces of TW80/OA composite vesicles were determined by infrared spectroscopy. Vitamin C (VC) was used as a model drug, and the TW80/OA/VC vesicles showed an encapsulation rate of 48.87% and a drug-loading capacity of 13.13% at a VC concentration of 1 mg/mL, pH = 5.5, and T = 25 °C. The vesicles were also found to have a high VC concentration and a high drug loading capacity. The in vitro release experiments demonstrated that the TW80/OA/VC vesicles could accomplish the drug release process in a physiological environment. The results of in vitro free radical scavenging experiments showed that the TW80/OA/VC vesicles could maximize the scavenging rate of DPPH free radicals up to 97.61%. This study can provide a fundamental theoretical basis for applying drug carrier vesicles in cosmetics.

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Funding

We received support of the Heilongjiang Province key research and development plan project (JD22A016), Heilongjiang Province “Double first-class” discipline collaborative innovation achievement construction project (LJGXCG2022-126), Basic Scientific Research Project for Heilongjiang Provincial Colleges and Universities (2022-KYYWF-0609), Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation Open Fund Project (kfkt2023-14), Heilongjiang Huahao Testing Technology Service Co., LTD.

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  1. College of Pharmacy, Jiamusi University, Heilongjiang 154007, Jiamusi, People’s Republic of China

    Yuxi Gong, Wei Yang, Chao Wu, Xinyu Fan, Xiangyu Zhang, Jinlian Li & Dongmei Wu

  2. Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, Jiamusi University, Jiamusi, 154007, People’s Republic of China

    Yuxi Gong, Xiangyu Zhang, Jinlian Li & Dongmei Wu

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Contributions

Conceptualization, formal analysis and investigation, Y.G.; data curation, Y.G., W.Y., C.W. and X.F., writing—original draft, Y.G.; writing—review & editing, X.Z., L.L. and D.W.; supervision, X.Z., L.L. and D.W.; project administration, X.Z.; funding acquisition, X.Z., L.L. and D.W. All authors reviewed the manuscript.

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Correspondence to Xiangyu Zhang, Jinlian Li or Dongmei Wu.

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Gong, Y., Yang, W., Wu, C. et al. Design of Tween80/oleic acid composite vesicle and its application in controlled release of vitamin C. Colloid Polym Sci 302, 561–571 (2024). https://doi.org/10.1007/s00396-023-05212-z

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