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A novel green amino acid derivative hydrogel with multi-stimulus responsiveness

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Abstract

Even though amino acid derivatives are always used as the building blocks to construct gels in supramolecular chemistry, there is still no report about N-alpha-Fmoc-L-valine (Fmoc-V) hydrogel induced by metal ions. Herein, a novel green Fmoc-V hydrogel with stimuli responsiveness was reported. A total of eight metal ions are applied to fabricate gels, but only Zn2+ and Cu2+ can induce Fmoc-V hydrogel formation. The formation of Fmoc-V hydrogel is verified by rheometer detection. FT-IR, UV–vis, and SAXS detections are used to study the formation mechanism of Fmoc-V hydrogel, implying hydrogen bond, metal–ligand, and π-π stacking interactions are the driving forces to gel formation. Moreover, this novel green hydrogel with high electrical conductivity performs multiple stimulus responsiveness to temperature, metal ion, and acid, illustrating its great potential applications in various areas.

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Funding

We greatly acknowledge financial support by Young Backbone Teachers Visiting Scholar Program in China of Jining Medical University, the Undergraduate Training Programs for Innovation of Shandong Province (No. S202110443035) and Shandong Provincial Natural Science Foundation (No. ZR2019PB006).

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Authors and Affiliations

  1. College of Basic Medicine & Laboratory of New Antitumor Drug Molecular Design and Synthesis of Jining Medical University, Jining Medical University, Jining, 272067, People’s Republic of China

    Mingfang Ma, Tongyu Wang, Renrui Liu, Wenwen Jiang, Zhaocan Niu, Mingjuan Bai, Weiwei Wu & Wenqing Shang

  2. School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, People’s Republic of China

    Aiyou Hao

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  1. Mingfang Ma
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  2. Tongyu Wang
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Ma, M., Wang, T., Liu, R. et al. A novel green amino acid derivative hydrogel with multi-stimulus responsiveness. Colloid Polym Sci 301, 569–576 (2023). https://doi.org/10.1007/s00396-023-05095-0

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