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Drug delivery of sulphanilamide using modified porous calcium carbonate

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Abstract

Porous calcium carbonate material has been modified with a sulpha drug, sulphanilamide, proposed to be used as a dressing material. The material was found to have a better drug loading if modified using a polymer, polyethylene glycol (PEG#12000), used during synthesis of the material. This modified drug delivery matrix has been characterized through TEM, FESEM, FTIR, surface analysis, and powder XRD and compared with those of the unmodified ones. The materials were found to have mixed porosity in the macroporous to mesoporous range, and the modifications were supported by the results of FTIR, TEM, and FESEM. One of the PEG-modified matrix was found to have satisfactory drug loading and sustained release properties. For studies on drug release, a solution of physiological pH (5.5), 0.3% and 0.9% NaCl solutions of pH 5.5 were chosen to mimic the different conditions of skin to simulate a sustained release application for the treatment of wounds.

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Acknowledgements

Pritam Singh gratefully acknowledges the University Grants Commission (UGC) (Ref. No. 20/12/2015(ii)EU-V dated 24.08.2016) for providing necessary fellowship. We also express our sincere gratitude to Mr. Nayan Ranjan Saha, Department of Chemical Technology, University of Calcutta, India, for measuring the XRD and Mr. Ashutosh Mishra, Research Scholar, Department of Chemistry, IIT BHU, for XRD analysis.

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  1. Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata, 700009, India

    Pritam Singh & Kamalika Sen

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  1. Pritam Singh
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  2. Kamalika Sen
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Correspondence to Kamalika Sen.

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Singh, P., Sen, K. Drug delivery of sulphanilamide using modified porous calcium carbonate. Colloid Polym Sci 296, 1711–1718 (2018). https://doi.org/10.1007/s00396-018-4392-x

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  • DOI: https://doi.org/10.1007/s00396-018-4392-x

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