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Cardiometabolic effects of two coffee blends differing in content for major constituents in overweight adults: a randomized controlled trial

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Abstract

Purpose

The hypothesis was tested that coffee types differing in content of major constituents also differ with regard to cardiometabolic effects.

Methods

Overweight persons (n = 118) were randomized to consume a dark roast [rich in N-methylpyridinium (NMP)] or medium roast (rich in caffeoylquinic acids, trigonelline) coffee blend for 3 months, after a washout period of 4 weeks. Before and after the intervention period, body weight and 15 further general and biochemical parameters were determined.

Results

Participants consumed an average of 4–5 cups per day. Mean body weight, body mass index and waist circumference did not change during the coffee consumption phase in either of the study groups. Systolic blood pressure decreased in the dark roast coffee group only (p < 0.05). High-density lipoprotein cholesterol levels increased in the medium roast coffee group only, and triglyceride levels increased in the dark roast coffee group only. Glucoregulation and insulin levels were not affected, although there was a small increase of hemoglobin A1c values in both groups. An increase of adiponectin levels occurred in the medium roast coffee group only and was negatively associated with NMP concentrations. Differences did not remain statistically significant after correction for multiple testing.

Conclusions

Medium and dark roast coffee blends exert small but possibly relevant different cardiometabolic effects. Further studies of health outcomes in relation to coffee constituents seem warranted.

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Acknowledgments

S. Martin and K. Kempf received a research grant from Tchibo GmbH. We thank B. Arnold for expert help in conducting the study.

Conflict of interest

The authors G. Bytof, H. Stiebitz and I. Lantz are employees of Tchibo GmbH, Germany, the company that sponsored part of this research. H. Kolb received consulting fees from Tchibo GmbH. S. Martin and K. Kempf received a research grant from Tchibo GmbH. B. Gärtner, T. Hofmann and R. Lang declare that they have no conflict of interest.

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Authors and Affiliations

  1. West-German Centre of Diabetes and Health, Düsseldorf Catholic Hospital Group, Hohensandweg 37, 40591, Düsseldorf, Germany

    Kerstin Kempf, Hubert Kolb, Babette Gärtner & Stephan Martin

  2. Tchibo GmbH, Hamburg, Germany

    Gerhard Bytof, Herbert Stiebitz & Ingo Lantz

  3. Chair of Food Chemistry and Molecular Sensory Science, Technische Universität München, Lise-Meitner-Straße 34, 85354, Freising-Weihenstephan, Germany

    Roman Lang & Thomas Hofmann

Authors
  1. Kerstin Kempf
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  2. Hubert Kolb
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  4. Gerhard Bytof
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  7. Roman Lang
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  9. Stephan Martin
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Corresponding author

Correspondence to Kerstin Kempf.

Additional information

Clinical trials.gov ID NCT01759329.

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Kempf, K., Kolb, H., Gärtner, B. et al. Cardiometabolic effects of two coffee blends differing in content for major constituents in overweight adults: a randomized controlled trial. Eur J Nutr 54, 845–854 (2015). https://doi.org/10.1007/s00394-014-0763-3

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  • DOI: https://doi.org/10.1007/s00394-014-0763-3

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