Zusammenfassung
Ziel der vorliegenden Arbeit ist ein Überblick über aktuelle Konzepte in der Behandlung von osteoporotischen Wirbelkörperfrakturen, über Risikofaktoren, über das klinische Erscheinungsbild und das konservative und operative Management. Osteoporotische Wirbelkörperfrakturen sind ein weit verbreitetes Problem, allein in den USA sind jährlich zwischen 700.000 und 1,5 Mio. Erwachsene betroffen. Osteoporotische Wirbelkörperfrakturen können schwere körperliche Einschränkungen verursachen, einschließlich Rückenschmerzen, Funktionsstörungen und fortschreitender Kyphose der Brustwirbelsäule. Immer noch ist die Sterblichkeit nach osteoporotischen Wirbelkörperfrakturen im Vergleich zu gleichaltrigen Kontrollen erhöht. In der Versorgungsrealität über den Erdball verteilt finden sich die Verfechter der rein konservativen Therapie genauso wie die Befürworter der operativen Behandlung. Zusammenfassend kann man sagen, dass das Verständnis der Risikofaktoren, eine angemessene klinische Bewertung und Behandlungsstrategien von entscheidender Bedeutung sind. Wenn eine Operation indiziert ist, dann zeigt die Ballonkyphoplastie im Vergleich zur nichtchirurgischen Behandlung eine signifikant bessere Schmerzreduktion und eine niedrigere Sterblichkeit.
Abstract
The aim of the present work is an overview of current concepts in the treatment of osteoporotic vertebral fractures, risk factors, clinical presentation and conservative and operative management. Osteoporotic vertebral fractures are a widespread problem, affecting between 700,000 and 1.5 million adults annually in the USA alone. Osteoporotic vertebral fractures can cause severe physical impairment, including back pain, dysfunction, and progressive thoracic kyphosis. Mortality after osteoporotic vertebral fractures is still increased compared to age-matched controls. In the reality of care, advocates of purely conservative therapy as well as advocates of surgical treatment can be found all over the world. In summary, understanding the risk factors, appropriate clinical evaluation and treatment strategies are crucial. When surgery is indicated, balloon kyphoplasty shows significantly better pain reduction and lower mortality compared to nonsurgical treatment.
Literatur
Alsoof D, Anderson G, McDonald CL et al (2022) Diagnosis and management of vertebral compression fracture. Am J Med 94:44–50. https://doi.org/10.1016/j.amjmed.2022.02.035
Anderson PA, Froyshteter AB, Tontz WL (2013) Meta-analysis of vertebral augmentation compared with conservative treatment for osteoporotic spinal fractures. J Bone Miner Res 28:372–382. https://doi.org/10.1002/jbmr.1762
Bae JS, Park JH, Kim KJ et al (2017) Analysis of risk factors for secondary new vertebral compression fracture following percutaneous vertebroplasty in patients with osteoporosis. World Neurosurg 99:387–394. https://doi.org/10.1016/j.wneu.2016.12.038
Beall D, Lorio MP, Yun BM et al (2018) Review of vertebral augmentation: an updated meta-analysis of the effectiveness. Int J Spine Surg 12:295–321. https://doi.org/10.14444/5036
Belkoff SM, Jasper LE, Stevens SS (2002) An ex vivo evaluation of an inflatable bone tamp used to reduce fractures within vertebral bodies under load. Spine 27:1640–1643. https://doi.org/10.1097/00007632-200208010-00009
Berlemann U, Ferguson SJ, Nolte L‑P, Heini PF (2002) Adjacent vertebral failure after vertebroplasty. J Bone Joint Surg Br 84-B:748–752. https://doi.org/10.1302/0301-620x.84b5.0840748
Blattert TR, Schnake KJ, Gonschorek O et al (2019) Nonsurgical and surgical management of osteoporotic vertebral body fractures: recommendations of the spine section of the German society for orthopaedics and trauma (DGOU). Orthopade 48:84–91. https://doi.org/10.1007/s00132-018-03666-6
Cauley JA, Thompson DE, Ensrud KC et al (2000) Risk of mortality following clinical fractures. Osteoporos Int 11:556–561. https://doi.org/10.1007/s001980070075
Cosman F, de Beur SJ, LeBoff MS et al (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 25:2359–2381. https://doi.org/10.1007/s00198-014-2794-2
Edidin AA, Ong KL, Lau E, Kurtz SM (2015) Morbidity and mortality after vertebral fractures. Spine 40:1228–1241. https://doi.org/10.1097/brs.0000000000000992
Ensrud KE, Schousboe JT (2011) Vertebral fractures. N Engl J Med 364:1634–1642. https://doi.org/10.1056/nejmcp1009697
Hoyt D, Urits I, Orhurhu V et al (2020) Current concepts in the management of vertebral compression fractures. Curr Pain Headache Rep. https://doi.org/10.1007/s11916-020-00849-9
Kanis JA, Kanis JA (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. Osteoporos Int 4:368–381. https://doi.org/10.1007/bf01622200
Langdon J, Way A, Heaton S et al (2010) Vertebral compression fractures—new clinical signs to aid diagnosis. Ann Royal Coll Surg 92:163–166. https://doi.org/10.1308/003588410X12518836440162
Lau E, Ong K, Kurtz S et al (2008) Mortality following the diagnosis of a vertebral compression fracture in the medicare population. J Bone Joint Surg Am 90:1479–1486. https://doi.org/10.2106/jbjs.g.00675
Lieberman IH, Dudeney S, Reinhardt M‑K, Bell G (2001) Initial outcome and efficacy of “Kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures. Spine 26:1631–1637. https://doi.org/10.1097/00007632-200107150-00026
Mannava R (2017) Vertebral compression fractures. Radiopaedia. https://doi.org/10.53347/rid-53015
McCarthy J, Davis A (2016) Diagnosis and management of vertebral compression fractures. Am Fam Physician 94:44–50. https://doi.org/10.1016/j.amjmed.2022.02.035
van Meirhaeghe J, Bastian L, Boonen S et al (2013) A randomized trial of balloon kyphoplasty and nonsurgical management for treating acute vertebral compression fractures: vertebral body kyphosis correction and surgical parameters. Spine 38:971–983. https://doi.org/10.1097/BRS.0b013e31828e8e22
Minne HW (1991) Lebensqualität im Alter – bedroht durch Osteoporose? Pharmazie in unserer Zeit 20:109–114. https://doi.org/10.1002/pauz.19910200309
Nieuwenhuijse MJ, van Rijswijk CSP, van Erkel AR, Dijkstra SPD (2012) The intravertebral cleft in painful long-standing osteoporotic vertebral compression fractures treated with percutaneous vertebroplasty. Spine 37:974–981. https://doi.org/10.1097/brs.0b013e318238bf22
Röllinghoff M, Zarghooni K, Schlüter-Brust K et al (2010) Indications and contraindications for vertebroplasty and kyphoplasty. Arch Orthop Trauma Surg 130:765–774. https://doi.org/10.1007/s00402-010-1083-6
Spiegl U, Bork H, Grüninger S et al (2021) Originalarbeit: Osteoporotische Frakturen der Brust- und Lendenwirbelkörper: Diagnostik und konservative Therapie. Dtsch Arztebl Int 118:670–677. https://doi.org/10.3238/ARZTEBL.M2021.0295
Svedbom A, Alvares L, Cooper C et al (2013) Balloon kyphoplasty compared to vertebroplasty and nonsurgical management in patients hospitalised with acute osteoporotic vertebral compression fracture: a UK cost-effectiveness analysis. Osteoporos Int 24:355–367. https://doi.org/10.1007/s00198-012-2102-y
Takahara K, Kamimura M, Moriya H et al (2016) Risk factors of adjacent vertebral collapse after percutaneous vertebroplasty for osteoporotic vertebral fracture in postmenopausal women. BMC Musculoskelet Disord 17:12. https://doi.org/10.1186/s12891-016-0887-0
Whooley MA, Cauley JA, Kip KE et al (1999) Depression, falls, and risk of fracture in older women. Psychosom Med 61:103–104. https://doi.org/10.1097/00006842-199901000-00114
Wong CC, McGirt MJ (2013) Vertebral compression fractures: a review of current management and multimodal therapy. J Multidiscip Healthcare 6:205–214. https://doi.org/10.2147/JMDH.S31659
Wood PR, Mahoney PF, Cooper JP (2009) Deep venous thrombosis and pulmonary embolism. In: Trauma and orthopedic surgery in clinical practice. Springer, London, S 109–112
Zhang T (2017) Does percutaneous vertebroplasty or balloon kyphoplasty for osteoporotic vertebral compression fractures increase the incidence of new vertebral fractures? A meta-analysis. Pain Physician 20(1):E13–E28. https://doi.org/10.36076/ppj.2017.1.e13
(1993) Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis. The American Journal of Medicine 94:646–650. https://doi.org/10.1016/0002-9343(93)90218‑e
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
A. Benditz und J. Jerosch geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
Additional information
Redaktion
Joachim Grifka, Bad Abbach
Burkhard Möller, Bern
QR-Code scannen & Beitrag online lesen
Rights and permissions
About this article
Cite this article
Benditz, A., Jerosch, J. Osteoporotische Wirbelkörperfrakturen – Von der Diagnose zur Therapie. Z Rheumatol 82, 18–24 (2023). https://doi.org/10.1007/s00393-022-01255-9
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00393-022-01255-9