Abstract
Background
Robotic (RNS) or magnetic navigation systems (MNS) are available for remotely performed catheter ablation for atrial fibrillation (AF).
Objective
The present study compares remotely assisted catheter navigation (RAN) to standard manual navigation (SMN) and both systems amongst each other.
Methods
The analysis is based on a sub-cohort enrolled by five hospitals from the multicenter German ablation Registry.
Results
Out of 2442 patients receiving catheter ablation of AF, 267 (age 61.4 ± 10.4, 69.7% male) were treated using RAN (RNS n = 187, 7.7% vs. MNS n = 80, 3.3%). Fluoroscopy time [RNS median 17 (IQR 12–25) min vs. MNS 22 (16–32) min; p < 0.001] and procedure duration [RNS 180 (145–220) min vs. MNS 265 (210–305) min; p < 0.001] were significantly different. Comparing RAN (11%) to SMN (89%) fluoroscopy time (RAN 19 (13–27) min, vs. SMN 25 (16–40) min; p < 0.001), energy delivery (RAN 3168 (2280–3840) s vs. SMN 2640 (IQR 1799–3900) s; p = 0.008) and procedure duration [RAN 195 (150–255) min vs. SMN 150 (120–150) min; p = 0.001] differed significantly. In terms of acute and 12 months outcome, no differences were seen between the two systems or in comparison to SMN.
Conclusion
AF ablation can be performed safely, with high acute success rates using RAN. RNS results in less fluoroscopy burden and shorter procedure durations. Compared to SMN, a reduced fluoroscopy burden, prolonged procedure and ablation duration were observed using RAN. Overall, the number of RAN procedures is small suggesting low impact on clinical routine of AF ablation.
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References
Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, D’Agostino RB, Massaro JM, Beiser A, Wolf PA, Benjamin EJ (2004) Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 110(9):1042–1046. https://doi.org/10.1161/01.CIR.0000140263.20897.42
Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE (2001) Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 285(18):2370–2375
Pappone C, Augello G, Gugliotta F, Santinelli V (2007) Robotic and magnetic navigation for atrial fibrillation ablation. How and why? Expert Rev Med Devices 4(6):885–894. https://doi.org/10.1586/17434440.4.6.885
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K (2016) 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Europace Eur Pacing, Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol 18(11):1609–1678. https://doi.org/10.1093/europace/euw295
Deng H, Bai Y, Shantsila A, Fauchier L, Potpara TS, Lip GYH (2017) Clinical scores for outcomes of rhythm control or arrhythmia progression in patients with atrial fibrillation: a systematic review. Clin Res Cardiol Off J Ger Card Soci 106(10):813–823. https://doi.org/10.1007/s00392-017-1123-0
Pezawas T, Ristl R, Schukro C, Schmidinger H (2016) Health-related quality of life changes in patients undergoing repeated catheter ablation for atrial fibrillation. Clin Res Cardiol Off J Germ Card Soc 105(1):1–9. https://doi.org/10.1007/s00392-015-0879-3
Ouyang F, Bansch D, Ernst S, Schaumann A, Hachiya H, Chen M, Chun J, Falk P, Khanedani A, Antz M, Kuck KH (2004) Complete isolation of left atrium surrounding the pulmonary veins: new insights from the double-Lasso technique in paroxysmal atrial fibrillation. Circulation 110(15):2090–2096. https://doi.org/10.1161/01.CIR.0000144459.37455.EE
Miyazaki S, Shah AJ, Xhaet O, Derval N, Matsuo S, Wright M, Nault I, Forclaz A, Jadidi AS, Knecht S, Rivard L, Liu X, Linton N, Sacher F, Hocini M, Jais P, Haissaguerre M (2010) Remote magnetic navigation with irrigated tip catheter for ablation of paroxysmal atrial fibrillation. Circ Arrhythmia Electrophysiol 3(6):585–589. https://doi.org/10.1161/CIRCEP.110.957803
Schmidt B, Chun KR, Tilz RR, Koektuerk B, Ouyang F, Kuck KH (2008) Remote navigation systems in electrophysiology. Europace Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol 10(Suppl 3):iii57–iii61. https://doi.org/10.1093/europace/eun234
Steven D, Servatius H, Rostock T, Hoffmann B, Drewitz I, Mullerleile K, Sultan A, Aydin MA, Meinertz T, Willems S (2010) Reduced fluoroscopy during atrial fibrillation ablation: benefits of robotic guided navigation. J Cardiovasc Electrophysiol 21(1):6–12. https://doi.org/10.1111/j.1540-8167.2009.01592.x
Tada H, Oral H, Wasmer K, Greenstein R, Pelosi F Jr, Knight BP, Strickberger SA, Morady F (2002) Pulmonary vein isolation: comparison of bipolar and unipolar electrograms at successful and unsuccessful ostial ablation sites. J Cardiovasc Electrophysiol 13(1):13–19
Pappone C, Rosanio S, Oreto G, Tocchi M, Gugliotta F, Vicedomini G, Salvati A, Dicandia C, Mazzone P, Santinelli V, Gulletta S, Chierchia S (2000) Circumferential radiofrequency ablation of pulmonary vein ostia: a new anatomic approach for curing atrial fibrillation. Circulation 102(21):2619–2628
Saliba W, Reddy VY, Wazni O, Cummings JE, Burkhardt JD, Haissaguerre M, Kautzner J, Peichl P, Neuzil P, Schibgilla V, Noelker G, Brachmann J, Di Biase L, Barrett C, Jais P, Natale A (2008) Atrial fibrillation ablation using a robotic catheter remote control system: initial human experience and long-term follow-up results. J Am Coll Cardiol 51(25):2407–2411. https://doi.org/10.1016/j.jacc.2008.03.027
Kettering K, Yim DH, Benz A, Gramley F (2017) Catheter ablation of paroxysmal atrial fibrillation: circumferential pulmonary vein ablation: success rates with and without exclusion of areas adjacent to the esophagus. Clin Res Cardiol Off J Ger Card Soc 106(9):743–751. https://doi.org/10.1007/s00392-017-1118-x
Reddy VY, Neuzil P, Malchano ZJ, Vijaykumar R, Cury R, Abbara S, Weichet J, McPherson CD, Ruskin JN (2007) View-synchronized robotic image-guided therapy for atrial fibrillation ablation: experimental validation and clinical feasibility. Circulation 115(21):2705–2714. https://doi.org/10.1161/CIRCULATIONAHA.106.677369
Al-Ahmad A, Grossman JD, Wang PJ (2005) Early experience with a computerized robotically controlled catheter system. J Interv Card Electrophysiol Int J Arrhythm Pacing 12(3):199–202. https://doi.org/10.1007/s10840-005-0325-y
Steven D, Rostock T, Servatius H, Hoffmann B, Drewitz I, Mullerleile K, Meinertz T, Willems S (2008) Robotic versus conventional ablation for common-type atrial flutter: a prospective randomized trial to evaluate the effectiveness of remote catheter navigation. Heart Rhythm Off J Heart Rhythm Soc 5(11):1556–1560. https://doi.org/10.1016/j.hrthm.2008.08.028
Faddis MN, Blume W, Finney J, Hall A, Rauch J, Sell J, Bae KT, Talcott M, Lindsay B (2002) Novel, magnetically guided catheter for endocardial mapping and radiofrequency catheter ablation. Circulation 106(23):2980–2985
Ernst S, Ouyang F, Linder C, Hertting K, Stahl F, Chun J, Hachiya H, Bansch D, Antz M, Kuck KH (2004) Initial experience with remote catheter ablation using a novel magnetic navigation system: magnetic remote catheter ablation. Circulation 109(12):1472–1475. https://doi.org/10.1161/01.CIR.0000125126.83579.1B
Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d’Avila A, de Groot N, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T (2017) 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm Off J Heart Rhythm Soc 14(10):e275–e444. https://doi.org/10.1016/j.hrthm.2017.05.012
Spragg DD, Dalal D, Cheema A, Scherr D, Chilukuri K, Cheng A, Henrikson CA, Marine JE, Berger RD, Dong J, Calkins H (2008) Complications of catheter ablation for atrial fibrillation: incidence and predictors. J Cardiovasc Electrophysiol 19(6):627–631. https://doi.org/10.1111/j.1540-8167.2008.01181.x
Hoffmann BA, Kuck KH, Andresen D, Spitzer SG, Hoffmann E, Schumacher B, Eckardt L, Brachmann J, Becker R, Steven D, Rostock T, Junger C, Senges J, Willems S (2014) Impact of structural heart disease on the acute complication rate in atrial fibrillation ablation: results from the German Ablation Registry. J Cardiovasc Electrophysiol 25(3):242–249. https://doi.org/10.1111/jce.12319
Chun JK, Ernst S, Matthews S, Schmidt B, Bansch D, Boczor S, Ujeyl A, Antz M, Ouyang F, Kuck KH (2007) Remote-controlled catheter ablation of accessory pathways: results from the magnetic laboratory. Eur Heart J 28(2):190–195. https://doi.org/10.1093/eurheartj/ehl447
Proietti R, Pecoraro V, Di Biase L, Natale A, Santangeli P, Viecca M, Sagone A, Galli A, Moja L, Tagliabue L (2013) Remote magnetic with open-irrigated catheter vs. manual navigation for ablation of atrial fibrillation: a systematic review and meta-analysis. Europace Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol 15(9):1241–1248. https://doi.org/10.1093/europace/eut058
Shurrab M, Danon A, Lashevsky I, Kiss A, Newman D, Szili-Torok T, Crystal E (2013) Robotically assisted ablation of atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol 169(3):157–165. https://doi.org/10.1016/j.ijcard.2013.08.086
Schmidt B, Tilz RR, Neven K, Julian Chun KR, Furnkranz A, Ouyang F (2009) Remote robotic navigation and electroanatomical mapping for ablation of atrial fibrillation: considerations for navigation and impact on procedural outcome. Circ Arrhythmia Electrophysiol 2(2):120–128. https://doi.org/10.1161/CIRCEP.108.818211
Rillig A, Schmidt B, Steven D, Meyerfeldt U, Wissner LDIB, Becker E, Thomas R, Wohlmuth D, Gallinghouse P, Scholz GJ, Jung E, Willems W, Natale S, Ouyang A, Kuck F, Tilz KH R (2013) Study design of the man and machine trial: a prospective international controlled noninferiority trial comparing manual with robotic catheter ablation for treatment of atrial fibrillation. J Cardiovasc Electrophysiol 24(1):40–46. https://doi.org/10.1111/j.1540-8167.2012.02418.x
Rillig A, Lin T, Schmidt B, Feige B, Heeger C, Wegner J, Wissner E, Metzner A, Arya A, Mathew S, Wohlmuth P, Ouyang F, Kuck KH, Tilz RR (2016) Experience matters: long-term results of pulmonary vein isolation using a robotic navigation system for the treatment of paroxysmal atrial fibrillation. Clin Res Cardiol Off J Ger Card Soc 105(2):106–116. https://doi.org/10.1007/s00392-015-0892-6
Verma A, Jiang CY, Betts TR, Chen J, Deisenhofer I, Mantovan R, Macle L, Morillo CA, Haverkamp W, Weerasooriya R, Albenque JP, Nardi S, Menardi E, Novak P, Sanders P, Investigators SAI (2015) Approaches to catheter ablation for persistent atrial fibrillation. N Engl J Med 372(19):1812–1822. https://doi.org/10.1056/NEJMoa1408288
Maurer T, Rottner L, Makimoto H, Reissmann B, Heeger CH, Lemes C, Fink T, Riedl J, Santoro F, Wohlmuth P, Volkmer M, Mathew S, Metzner A, Ouyang F, Kuck KH, Sohns C (2018) The best of two worlds? Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation. Clin Res Cardiol Off J Ger Card Soc. https://doi.org/10.1007/s00392-018-1270-y
Luthje L, Vollmann D, Seegers J, Dorenkamp M, Sohns C, Hasenfuss G, Zabel M (2011) Remote magnetic versus manual catheter navigation for circumferential pulmonary vein ablation in patients with atrial fibrillation. Clin Res Cardiol Off J Ger Card Soc 100(11):1003–1011. https://doi.org/10.1007/s00392-011-0333-0
Maurer T, Sohns C, Deiss S, Rottner L, Wohlmuth P, Reissmann B, Heeger CH, Lemes C, Riedl J, Santoro F, Mathew S, Metzner A, Ouyang F, Kuck KH, Wissner E (2017) Significant reduction in procedure duration in remote magnetic-guided catheter ablation of atrial fibrillation using the third-generation magnetic navigation system. J Interv Card Electrophysiol Int J Arrhythm Pacing 49(3):219–226. https://doi.org/10.1007/s10840-017-0261-7
Da Costa A, Guichard JB, Maillard N, Romeyer-Bouchard C, Gerbay A, Isaaz K (2017) Substantial superiority of Niobe ES over Niobe II system in remote-controlled magnetic pulmonary vein isolation. Int J Cardiol 230:319–323. https://doi.org/10.1016/j.ijcard.2016.12.115
Yuan S, Holmqvist F, Kongstad O, Jensen SM, Wang L, Ljungstrom E, Hertervig E, Borgquist R (2017) Long-term outcomes of the current remote magnetic catheter navigation technique for ablation of atrial fibrillation. Scand Cardiovasc J SCJ 51(6):308–315. https://doi.org/10.1080/14017431.2017.1384566
Dello Russo A, Fassini G, Conti S, Casella M, Di Monaco A, Russo E, Riva S, Moltrasio M, Tundo F, De Martino G, Gallinghouse GJ, Di Biase L, Natale A, Tondo C (2016) Analysis of catheter contact force during atrial fibrillation ablation using the robotic navigation system: results from a randomized study. J Interv Card Electrophysiol Int J Arrhythm Pacing. https://doi.org/10.1007/s10840-016-0102-0
Koutalas E, Bertagnolli L, Sommer P, Richter S, Rolf S, Breithardt O, Bollmann A, Hindricks G, Arya A (2014) Efficacy and safety of remote magnetic catheter navigation vs. manual steerable sheath-guided ablation for catheter ablation of atrial fibrillation: a case–control study. Europace Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol. https://doi.org/10.1093/europace/euu224
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van den Bruck, JH., Sultan, A., Lüker, J. et al. Remote vs. conventional navigation for catheter ablation of atrial fibrillation: insights from prospective registry data. Clin Res Cardiol 108, 298–308 (2019). https://doi.org/10.1007/s00392-018-1356-6
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DOI: https://doi.org/10.1007/s00392-018-1356-6