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Comparison of survival outcomes between laparoscopic and open colectomy for transverse colon cancer: a systematic review and meta-analysis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to compare laparoscopic with open resection for transverse colon cancer (TCC) regarding long-term survival outcomes.

Methods

Systematic literature search was performed on PubMed, Ovid, and Cochrane Library for studies comparing laparoscopic with open resection for TCC. The last search was performed on October 7, 2022. Oncological and survival outcomes were collected and analyzed. This meta-analysis was performed using Review Manager Software (v 5.3).

Results

This study included fifteen studies published between 2014 and 2022 with 2556 patients in total. When compared with the laparoscopic group, the open group had significantly more tumors locating on middle transverse colon (P = 0.006, OR = 0.67, 95%CI [0.50, 0.89], I2 = 12%) and more patients received transverse colectomy (P = 0.03, OR = 0.66, 95%CI [0.46, 0.96], I2 = 53%) as results. Comparable tumor stage (P = 0.13, OR = 0.81, 95%CI [0.62, 1.06], I2 = 55%) and number of lymph node harvested (P = 0.22, WMD =  −0.81, 95%CI [−2.09, 0.47], I2 = 73%) were observed between the two groups. As for survival outcomes, no significant difference was observed between the two groups for 5-year disease-free survival (DFS; P = 0.61, OR = 0.93, 95%CI [0.72, 1.21], I2 = 0%), 5-year overall survival (OS; P = 0.83, OR = 0.97, 95%CI [0.71, 1.32], I2 = 0%), 3-year DFS (P = 0.97, OR = 0.96, 95%CI [0.69, 1.32], I2 = 0%), and 3-year OS (P = 0.67, OR = 0.92, 95%CI [0.63, 1.35], I2 = 0%). In the subgroup analysis according to tumor stage, the results did not change.

Conclusion

Current evidence based on studies demonstrated that laparoscopic procedure could be safely performed for TCC, and it would not affect the long-term survival. Randomized clinical trials with a larger sample size are warranted in the future for further investigation.

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Data availability

The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.

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Authors and Affiliations

  1. Department of General Surgery, Jiu Jiang No.1 People’s Hospital, Jiujiang, Jiangxi Province, China

    Xianwei Liu, Xiaoyu Wu, Renfang Zhu & Wenbing Yu

  2. Department of Pathology, The Second Affiliated Hospital of Jiujiang University, No. 1699, Shili Avenue, Jiujiang, 332005, China

    Bing Zhou

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Contributions

Xianwei Liu and Bing Zhou wrote the main manuscript text; Xiaoyu Wu, Renfang Zhu, and Wenbing Yu prepared figures and tables. All authors reviewed the manuscript.

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Correspondence to Bing Zhou.

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Liu, X., Wu, X., Zhu, R. et al. Comparison of survival outcomes between laparoscopic and open colectomy for transverse colon cancer: a systematic review and meta-analysis. Int J Colorectal Dis 38, 111 (2023). https://doi.org/10.1007/s00384-023-04414-9

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