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Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal metastasis of colorectal cancer: long-term follow-up results at a single institution in Korea

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Abstract

Purpose

This study aimed to examine the 7-year follow-up results of cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) for peritoneal metastasis (PM) of colorectal cancer.

Methods

We performed 54 cases of CRS and IPC in 53 patients with PM of colorectal cancer from December 2011 to December 2013. We prospectively collected data and analyzed peritoneal carcinomatosis grade, completeness of cytoreduction, and long-term follow-up (median, 10 [range, 2–92] months) results.

Results

The mean peritoneal cancer index was 15 (1 ~ 35), and complete cytoreduction was possible in 35 (64.8%) patients. Excluding the four patients who died, 11 (22.4%) out of the 49 patients were alive at the time of the last follow-up, and the overall median survival period was 10.3 months. The overall 2- and 5-year survival rates were 31% and 17%, respectively. Patients with complete cytoreduction had a median survival period of 22.6 months, which was significantly longer than that for patients without complete cytoreduction (3.5 months) (P < 0.001). The 5-year survival rate for patients with complete cytoreduction was 24%, and four patients were still alive without disease.

Conclusions

CRS and IPC show a 5-year survival rate of 17% in patients with PM of colorectal cancer. A possibility of long-term survival is observed in a selected group. Multidisciplinary team evaluation for careful patient selection and CRS training program to achieve complete cytoreduction are significantly important factors in improving survival rate.

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Funding

The present research was supported by the research fund of Dankook University in 2022.

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Authors and Affiliations

  1. Department of Surgery, Dankook University Hospital College of Medicine, 201 Manghyangro, Dongnam-Gu, Cheonan, 31116, Republic of Korea

    Sung Chul Lee, Hwan Namgung, Jung Wook Suh & Dong-guk Park

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  1. Sung Chul Lee
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  2. Hwan Namgung
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  3. Jung Wook Suh
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  4. Dong-guk Park
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Contributions

Lee wrote the main manuscript text. Park and Namgung designed the research and revised the manuscript. Suh analyzed the medical records and revised the manuscript for important intellectual content. All authors reviewed the manuscript.

Corresponding author

Correspondence to Hwan Namgung.

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Ethics approval

This study was reviewed and approved by the appropriate institutional review board at Dankook University Hospital (No. 2022–09-021).

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The authors declare no competing interests.

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Lee, S.C., Namgung, H., Suh, J.W. et al. Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal metastasis of colorectal cancer: long-term follow-up results at a single institution in Korea. Int J Colorectal Dis 38, 44 (2023). https://doi.org/10.1007/s00384-023-04340-w

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  • DOI: https://doi.org/10.1007/s00384-023-04340-w

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