Abstract
Purpose
To determine the effectiveness of rectal washout in preventing local recurrence of distal colorectal cancer following curative resection.
Methods
A systematic review and meta-analysis was performed after a literature search was conducted on MEDLINE, EMBASE, the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), ClinicalTrials.gov, and the ISRCTN registry. The study was reported using PRISMA guidelines. The primary endpoint was incidence of local recurrence of cancer after distal colonic and rectal cancer surgery.
Results
After screening, 8 studies with a total sample size of 6739 patients were identified. At 5-year follow-up, local recurrence in the washout group (WO) was 6.08% compared to 9.48% in the no-washout group (NWO) group (OR 0.63, 95% CI = 0.51–0.78, Chi2 = 6.76, df = 7, p = 0.45). The relative risk reduction was 36.9%. To exclude a 36.9% relative risk reduction from 9.48 to 6.08% with a 5% significance level and 80% power a randomized control trial would require a total sample size of 1946 participants distributed equally between the two treatment arms.
Conclusion
It is safe to recommend the use of rectal washout for left sided and rectal tumour resections. It is a simple and safe step during colorectal surgery that appears to improve long-term oncological outcomes and was not reported to be associated with any complications.
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Data availability
On written request.
References
Ons.gov.uk. (2020) Cancer Registration Statistics, England - Office For National Statistics. Available at: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/2015. Accessed 16 Jun 2020
Agaba E (2004) Does rectal washout during anterior resection prevent local tumour recurrence. American society of colon and rectal surgeons 17:291–296
Constantinides VA, Cheetham D, Nicholls RJ, Tekkis PP (2008) Is rectal washout effective for preventing localized recurrence after anterior resection for rectal cancer? Dis Colon Rectum 51:1339–1344. https://doi.org/10.1007/s10350-008-9308-2
Galandiuck S, Wieand HS, Moertel CG (1992) Pattern of recurrence after curative resection of carcinoma of the colon and rectum. Surg Gynecol Obstet 174:27–32
McGregor JR, Galloway DJ, McCulloch P et al (1989) Anastomotic suture materials and implantation metastasis: an experimental study. Br J Surg 76:331–334. https://doi.org/10.1002/bjs.1800760405
Hubens G, Lafullarde T, Van Marck E (1994) Implantation of colon cancer cells on intact and damaged colon mucosa and serosa: an experimental study in the rat. Acta Chir Belg 94:258–262
Rold JD, Robins RE, Atkinson KG (1984) Pelvic recurrence after anterior resection and EEA stapling anastomosis for potentially curable carcinoma of the rectum. Am J Surg 147:629–32. 97. https://doi.org/10.1016/0002-9610(84)90128-4
Anderberg B, Enblad P, Sjodahl R, Wetterfors J (1984) Recurrent rectal carcinoma after anterior resection and rectal stapling. Br J Surg 71:98–100. https://doi.org/10.1002/bjs.1800710206
Hurst PA, Prout WG, Kelly JM, Bannister JJ, Walker RT (1982) Local recurrence after low anterior resection using the staple gun. Br J Surg 69:275–276. https://doi.org/10.1002/bjs.1800690515
Gertsch P, Baer HU, Kraft R (1992) Malignant cells are collected on circular staplers. Dis Colon Rectum 35:238–241. https://doi.org/10.1007/bf02051014
Umpleby HC, Fermor B, Symes MO (1984) Viability of exfoliated colorectal carcinoma cells. Br J Surg 71:659–663. https://doi.org/10.1002/bjs.1800710902
Neufert R, Teurneau-Hermansson (2018) Rectal washout in rectal cancer surgery: a survey of Swedish practice e Questionnaire. Rectal washout in Swedish rectal cancer surgery. Int J Surg 15:32–36. https://doi.org/10.1016/j.ijsu.2013.06.002
Moran B et al (2017) Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus. Colorectal Dis 19:18–36
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557
Jorgen F, Johannson R, Arnadottir H, Lindmark G (2017) The importance of rectal washout for the oncological outcome after Hartmann’s procedure for rectal cancer: analysis of population based data form the Swedish colorectal cancer registry. Tech Coloproctol 21:373–381. https://doi.org/10.1007/s10151-017-1637-5
Kodeda K, Holmberg E, Jorgen F, Nordgren S, Lindmark G (2010) Rectal washout and local recurrence of cancer after anterior resection. British J Surg 97:1587–1597. https://doi.org/10.1002/bjs.7472
DeFriend D et al (1992) Cutaneous perianal recurrence of cancer after anterior resection using the EEA stapling device. Ann R Coll Surg Engl 74:142–143
Norgren et al (1985) Anal implantation metastasis from carcinoma of the sigmoid colon and rectum–a risk when performing anterior resection with the EEA stapler? Br J Surg 72 602
Dafnis G, Nordstrom M (2013) Evaluation of the presence of intraluminal cancer cells following rectal washout in rectal cancer surgery. Tech Coloproctol 17:363–369. https://doi.org/10.1007/s10151-012-0924-4
Heald RJ, Ryall RD (1986) Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 28:1479–1482
Matsuda et al (2012) The effect of intraoperative rectal washout on local recurrence after rectal cancer surgery: a meta-analysis Ann Surg Oncol 20. https://doi.org/10.1245/s10434-012-2660-4
Guyatt GH et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ Clinical research 336(7650):924–926
Simillis C, Mistry K, Prabhudesai A (2013) Intraoperative rectal washout in rectal cancer surgery: a survey of current practice in the UK. Int J Surg 11:993–997
Rondelli F, Trastulli S, Cirocchi R et al (2012) Rectal washout and local recurrence in rectal resection for cancer: a meta-analysis. Colorectal Dis 14(11):1311–2132
Jenner DC, de Boer WB, Clarke G et al (1998) Rectal washout eliminates exfoliated malignant cells. Dis Colon Rectum 41:1432–4
Kawahara H, Hirai K, Aoki T et al (1998) Usefulness of intraluminal lavage for post-operative anastomosis recurrence in rectal cancer cases with double stapling technique [in Japanese]. Nippon Rinsho Geka Gakkai Zasshi 31:56–60
Matsuda A et al (2013) The effect of intraoperative rectal washout on local recurrence after rectal cancer surgery: a metaanalysis. Ann Surg Oncol 20(3):856–63
Nakano M, Negami N, Sengoku H et al (2004) Examination of exfoliated malignant cells collected with intraluminal lavage in anterior resection[in Japanese]. Juntendo Igaku 50:373–9
Pattana-arun J, Wolff BG (2008) Benefits of povidone-iodine solution in colorectal operations: science or legend. Dis Colon Rectum 51:966–71
Rondelli F, Trastulli S, Cirocchi R et al (2012) Rectal washout and local recurrence in rectal resection for cancer: a metaanalysis. Dis Colon Rectum 14:1313–21
Siddiqi N et al (2015) Benefit of rectal washout for anterior resection and left sided resections. Int J Surg 25:10–68
Shinto E, Mochizuki H, Hase K (1996) Improvement of anastomotic recurrence rate of rectal cancer by intra- operative anal side rectal lavage [in Japanese]. Nippon Daicho Komonbyo Gakkai Zasshi 49:399–404
Zhou C, Ren Y, Li J, Li X, He J, Liu P (2014) Systematic review and meta-analysis of rectal washout on risk of local recurrence for rectal cancer. J Surg Res 189:7e16
Included studies
Agaba E (2004) Does rectal washout during anterior resection prevent local tumour recurrence. American society of colon and rectal surgeons 17:291–296
Fukuda I, Kameyama M, Imaoka S (1991) Prevention of local recurrence after sphincter-saving resection for rectal cancer. Gan To Kagaku Ryoho 18:1965–1967
Jorgen F, Johannson R, Arnadottir H, Lindmark G (2017) The importance of rectal washout for the oncological outcome after Hartmann’s procedure for rectal cancer: analysis of population based data form the Swedish colorectal cancer registry. Tech Coloproctol 21:373–381. https://doi.org/10.1007/s10151-017-1637-5
Kodeda K, Holmberg E, Jorgen F, Nordgren S, Lindmark G (2010) Rectal washout and local recurrence of cancer after anterior resection. British jounral of surgery 97:1587–1597. https://doi.org/10.1002/bjs.7472
Long R, Edwards R (1989) Implantation metastasis as a cause of local recurrence of colorectal carcinoma. Am J Surg 1989(157):194–201. https://doi.org/10.1016/0002-9610(89)90527-8
Moosvi SR, Manley K, Hernon J (2018) The effect of rectal washout on local recurrence following rectal cancer surgery. Ann R Coll Surg Engl 100:146–151. https://doi.org/10.1308/rcsann.2017.0202
Terzi C, Unek T, Sagol O et al (2006) Is rectal washout necessary in anterior resection for rectal cancer? A prospective clinical study World J Surg 30:233–241
Xingmao Z, Jianjun B (2013) Analysis of outcomes of intra-operative rectal washout of patients with rectal cancer during anterior resections. Med Oncol 30:386. https://doi.org/10.1007/s12032-012-0386-6
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Solomon, J., Majeed, T., Magee, C. et al. The influence of intraoperative rectal washout on local recurrence of colorectal cancer following curative resection: a systematic review and meta-analysis. Int J Colorectal Dis 37, 403–409 (2022). https://doi.org/10.1007/s00384-021-04071-w
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DOI: https://doi.org/10.1007/s00384-021-04071-w