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Increasing colorectal cancer in the young population and tailoring of the colorectal cancer screening recommendations in subpopulation: a retrospective single-center study

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

The United States Preventive Services Task Force (USPSTF) newly drafted recommendations for colorectal cancer (CRC) screening age in average-risk individuals decreased to 45 years from 50 years. This study evaluates the change in the incidence of CRC, compares the demographic characteristics, characteristics of CRC, survival, and factors affecting the survival of younger (< 50 years) with the older (> 50 years) CRC-diagnosed population of Boston Medical Center (BMC). Also tailors the screening recommendations of CRC based on subpopulations.

Methods

A retrospective cohort study was conducted from 2004 to 2019 at BMC who underwent colonoscopy, to see newly diagnosed CRC. The analysis was done in R studio version 1.2.5033.

Results

The incidence rate of CRC is increasing in the younger population. The CRC in younger population was 350 and older was 2019. The most prevalent site among the younger population was rectum (33.33%), and most of the CRC were diagnosed at an advanced stage. Hispanics were less likely to be diagnosed with CRC in older age group (OR= 0.468, 95% CI 0.285, 0.796). Lower BMI was associated with a higher risk of mortality (p= 0.012). There was no difference in survival in younger and older populations.

Conclusions

CRC is increasing in the younger population, and Hispanics are diagnosed with CRC usually at a younger age. Early screening in young populations with average risk and even earlier screening in high-risk populations like Hispanics is warranted for timely recognition for prevention, early management, and reduction of mortality.

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Acknowledgements

We thank Dr Janice Weinberg and Stacey Hess Pino for their useful suggestions and comments.

Author information

Authors and Affiliations

  1. MS in Clinical Research, Boston University School of Medicine, Boston, MA, USA

    Samiksha Pandey

  2. William Beaumont Hospital-Royal Oak, Royal Oak, MI, USA

    Samiksha Pandey

  3. Boston University Schools of Public Health and Medicine, Boston, MA, USA

    Susan S. Fish

  4. Boston University School of Medicine, Boston, MA, USA

    Hemant K. Roy

  5. Baylor College of Medicine, Houston, TX, USA

    Hemant K. Roy

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  1. Samiksha Pandey
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  2. Susan S. Fish
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Correspondence to Samiksha Pandey.

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Dr Hemant Kumar Roy received grant from National Cancer Institute 1R33CA225323-01.

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Pandey, S., Fish, S.S. & Roy, H.K. Increasing colorectal cancer in the young population and tailoring of the colorectal cancer screening recommendations in subpopulation: a retrospective single-center study. Int J Colorectal Dis 36, 1515–1524 (2021). https://doi.org/10.1007/s00384-021-03934-6

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