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Evidence-based treatment strategies for acute diverticulitis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Diverticular disease is a common acquired condition of the lower gastrointestinal tract that may be associated with significant morbidity. The term encompasses a spectrum of pathological processes with varying clinical manifestations. The purpose of this review was to update the reader on modern evidence-based treatment strategies for acute diverticulitis.

Methods

A literature search of the PUBMED database was performed using the keywords ‘diverticulosis’, ‘diverticular disease’ and ‘diverticulitis’. Only articles published in the English language were included.

Results

Evidence-based treatment strategies for acute diverticulitis have evolved over time. Data have questioned the need for antibiotic therapy for Hinchey I disease and the role of percutaneous abscess drainage for Hinchey II. Clinical trials have demonstrated laparoscopic lavage is an appropriate option for select patients with Hinchey III disease and primary resection with anastomosis and defunctioning stoma may be considered in some cases of Hinchey IV disease.

Conclusion

Risk-adapted treatment strategies and operative decision-making for acute diverticulitis are increasingly based on a combination of patient and disease factors.

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References

  1. Hughes LE (1969) Postmortem survey of diverticular disease of the colon. II. The muscular abnormality of the sigmoid colon. Gut 10(5):344–351

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Welch CE, Allen AW, Donaldson GA (1953) An appraisal of resection of the colon for diverticulitis of the sigmoid. Ann Surg 138(3):332–343

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Parks TG (1969) Natural history of diverticular disease of the colon. A review of 521 cases. Br Med J 4(5684):639–642

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Parks TG (1968) Post-mortem studies on the colon with special reference to diverticular disease. Proc R Soc Med 61(9):932–934

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Parks TG (1975) Natural history of diverticular disease of the colon. Clin Gastroenterol 4(1):53–69

    CAS  Google Scholar 

  6. Everhart JE, Ruhl CE (2009) Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology 136(3):741–754

    PubMed  Google Scholar 

  7. Shahedi K et al (2013) Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy. Clin Gastroenterol Hepatol 11(12):1609–1613

    PubMed  PubMed Central  Google Scholar 

  8. Schieffer KM et al (2018) Pathophysiology of diverticular disease. Expert Rev Gastroenterol Hepatol 12(7):683–692

    CAS  PubMed  Google Scholar 

  9. Rezapour M, Ali S, Stollman N (2018) Diverticular disease: an update on pathogenesis and management. Gut Liver 12(2):125–132

    CAS  PubMed  Google Scholar 

  10. Painter NS, Burkitt DP (1971) Diverticular disease of the colon: a deficiency disease of Western civilization. Br Med J 2(5759):450–454

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Schieffer KM et al (2017) The microbial ecosystem distinguishes chronically diseased tissue from adjacent tissue in the sigmoid colon of chronic, recurrent diverticulitis patients. Sci Rep 7(1):8467

    PubMed  PubMed Central  Google Scholar 

  12. Hinchey EJ, Schaal PG, Richards GK (1978) Treatment of perforated diverticular disease of the colon. Adv Surg 12:85–109

    CAS  PubMed  Google Scholar 

  13. Sher ME et al (1997) Laparoscopic surgery for diverticulitis. Surg Endosc 11(3):264–267

    CAS  PubMed  Google Scholar 

  14. Wasvary H et al (1999) Same hospitalization resection for acute diverticulitis. Am Surg 65(7):632–635 discussion 636

    CAS  PubMed  Google Scholar 

  15. Hansen O, Graupe F, Stock W (1998) Prognostic factors in perforating diverticulitis of the large intestine. Chirurg 69(4):443–449

    CAS  Google Scholar 

  16. Kaiser AM et al (2005) The management of complicated diverticulitis and the role of computed tomography. Am J Gastroenterol 100(4):910–917

    PubMed  Google Scholar 

  17. Ambrosetti P et al (1997) Computed tomography in acute left colonic diverticulitis. Br J Surg 84(4):532–534

    CAS  PubMed  Google Scholar 

  18. Kruis W et al (2014) Diverticular disease: guidelines of the german society for gastroenterology, digestive and metabolic diseases and the german society for general and visceral surgery. Digestion 90(3):190–207

    PubMed  Google Scholar 

  19. Tonelli F et al (2009) Diverticular disease of the colon: diagnosis and treatment. Consensus Conference, 5th National Congress of the Italian Society of Academic Surgeons. Ann Ital Chir 80(1):3–8

    PubMed  Google Scholar 

  20. Andersen JC et al (2012) Danish national guidelines for treatment of diverticular disease. Dan Med J 59(5):C4453

    PubMed  Google Scholar 

  21. Fozard JB et al (2011) ACPGBI position statement on elective resection for diverticulitis. Colorectal Dis 13(Suppl 3):1–11

    PubMed  Google Scholar 

  22. Schultz JK et al (2020) European Society of Coloproctology: guidelines for the management of diverticular disease of the colon. Colorectal Dis

  23. Etzioni DA et al (2010) Outpatient treatment of acute diverticulitis: rates and predictors of failure. Dis Colon Rectum 53(6):861–865

    PubMed  Google Scholar 

  24. Jackson JD, Hammond T (2014) Systematic review: outpatient management of acute uncomplicated diverticulitis. Int J Colorectal Dis 29(7):775–781

    CAS  PubMed  Google Scholar 

  25. Rodríguez-Cerrillo M et al (2013) Treatment of elderly patients with uncomplicated diverticulitis, even with comorbidity, at home. Eur J Intern Med 24(5):430–432

    PubMed  Google Scholar 

  26. Biondo S et al (2014) Outpatient versus hospitalization management for uncomplicated diverticulitis: a prospective, multicenter randomized clinical trial (DIVER Trial). Ann Surg 259(1):38–44

    PubMed  Google Scholar 

  27. Chabok A et al (2012) Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg 99(4):532–539

    CAS  PubMed  Google Scholar 

  28. Unlü C et al (2010) A multicenter randomized clinical trial investigating the cost-effectiveness of treatment strategies with or without antibiotics for uncomplicated acute diverticulitis (DIABOLO trial). BMC Surg 10:23

    PubMed  PubMed Central  Google Scholar 

  29. van Dijk ST et al (2020) Observational versus antibiotic treatment for uncomplicated diverticulitis: an individual-patient data meta-analysis. Br J Surg

  30. van Dijk ST et al (2018) Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis. Am J Gastroenterol 113(7):1045–1052

    PubMed  Google Scholar 

  31. Daniels L et al (2017) Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis. Br J Surg 104(1):52–61

    CAS  PubMed  Google Scholar 

  32. Isacson D et al (2019) Long-term follow-up of the AVOD randomized trial of antibiotic avoidance in uncomplicated diverticulitis. Br J Surg 106(11):1542–1548

    CAS  PubMed  Google Scholar 

  33. O’Leary DP et al (2015) International, Expert-Based, Consensus Statement Regarding the Management of Acute Diverticulitis. JAMA Surg 150(9):899–904

    PubMed  Google Scholar 

  34. Eglinton T et al (2010) Patterns of recurrence in patients with acute diverticulitis. Br J Surg 97(6):952–957

    CAS  PubMed  Google Scholar 

  35. Ambrosetti P (2012) Value of CT for acute left-colonic diverticulitis: the surgeon’s view. Dig Dis 30(1):51–55

    PubMed  Google Scholar 

  36. Ambrosetti P, Becker C, Terrier F (2002) Colonic diverticulitis: impact of imaging on surgical management—a prospective study of 542 patients. Eur Radiol 12(5):1145–1149

    CAS  PubMed  Google Scholar 

  37. Galetin T et al (2018) Systematic review and comparison of national and international guidelines on diverticular disease. Int J Colorectal Dis 33(3):261–272

    CAS  PubMed  Google Scholar 

  38. Feingold D et al (2014) Practice parameters for the treatment of sigmoid diverticulitis. Dis Colon Rectum 57(3):284–294

    PubMed  Google Scholar 

  39. Sartelli M et al (2016) WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting. World J Emerg Surg 11:37

    PubMed  PubMed Central  Google Scholar 

  40. Leifeld L et al (2014) S2k guidelines diverticular disease/diverticulitis. Z Gastroenterol 52(7):663–710

    CAS  Google Scholar 

  41. Ambrosetti P et al (2005) Long-term outcome of mesocolic and pelvic diverticular abscesses of the left colon: a prospective study of 73 cases. Dis Colon Rectum 48(4):787–791

    PubMed  Google Scholar 

  42. Singh B et al (2008) The long-term results of percutaneous drainage of diverticular abscess. Ann R Coll Surg Engl 90(4):297–301

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Elagili F et al (2014) Outcomes of percutaneous drainage without surgery for patients with diverticular abscess. Dis Colon Rectum 57(3):331–336

    PubMed  Google Scholar 

  44. Gaertner WB et al (2013) Percutaneous drainage of colonic diverticular abscess: is colon resection necessary? Dis Colon Rectum 56(5):622–626

    PubMed  Google Scholar 

  45. Lambrichts DPV et al (2019) Multicentre study of non-surgical management of diverticulitis with abscess formation. Br J Surg 106(4):458–466

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Rogers AC et al (2012) Laparoscopic lavage for perforated diverticulitis: a population analysis. Dis Colon Rectum 55(9):932–938

    PubMed  Google Scholar 

  47. Vennix S et al (2015) Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 386(10000):1269–1277

    PubMed  Google Scholar 

  48. Schultz JK et al (2015) Laparoscopic lavage vs primary resection for acute perforated diverticulitis: the SCANDIV randomized clinical trial. JAMA 314(13):1364–1375

    CAS  PubMed  Google Scholar 

  49. Angenete E et al (2016) Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial DILALA. Ann Surg 263(1):117–122

    PubMed  Google Scholar 

  50. Kohl A et al (2018) Two-year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis. Br J Surg 105(9):1128–1134

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Vennix S et al (2017) Cost analysis of laparoscopic lavage compared with sigmoid resection for perforated diverticulitis in the Ladies trial. Br J Surg 104(1):62–68

    CAS  PubMed  Google Scholar 

  52. Gehrman J et al (2016) Health economic analysis of laparoscopic lavage versus Hartmann’s procedure for diverticulitis in the randomized DILALA trial. Br J Surg 103(11):1539–1547

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Cirocchi R et al (2018) Perforated sigmoid diverticulitis: Hartmann’s procedure or resection with primary anastomosis-a systematic review and meta-analysis of randomised control trials. Tech Coloproctol 22(10):743–753

    PubMed  Google Scholar 

  54. Shaban F et al (2018) Perforated diverticulitis: to anastomose or not to anastomose? A systematic review and meta-analysis. Int J Surg 58:11–21

    CAS  PubMed  Google Scholar 

  55. Gachabayov M et al (2018) Resection with primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a systematic review and meta-analysis. Colorectal Dis 20(9):753–770

    CAS  PubMed  Google Scholar 

  56. Ryan OK et al (2020) Systematic review and meta-analysis comparing primary resection and anastomosis versus Hartmann’s procedure for the management of acute perforated diverticulitis with generalised peritonitis. Tech Coloproctol

  57. Lambrichts DPV et al (2019) Hartmann’s procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial. Lancet Gastroenterol Hepatol 4(8):599–610

    PubMed  Google Scholar 

  58. Oberkofler CE et al (2012) A multicenter randomized clinical trial of primary anastomosis or Hartmann’s procedure for perforated left colonic diverticulitis with purulent or fecal peritonitis. Ann Surg 256(5):819–826 discussion 826-7

    PubMed  Google Scholar 

  59. Bridoux V et al (2017) Hartmann’s procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). J Am Coll Surg 225(6):798–805

    PubMed  Google Scholar 

  60. Binda GA et al (2012) Primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a prematurely terminated randomized controlled trial. Colorectal Dis 14(11):1403–1410

    CAS  PubMed  Google Scholar 

  61. Lee JM et al (2019) Hartmann’s procedure vs primary anastomosis with diverting loop ileostomy for acute diverticulitis: nationwide analysis of 2,729 Emergency Surgery Patients. J Am Coll Surg 229(1):48–55

    PubMed  Google Scholar 

  62. Peppas G et al (2007) Outcomes after medical and surgical treatment of diverticulitis: a systematic review of the available evidence. J Gastroenterol Hepatol 22(9):1360–1368

    PubMed  Google Scholar 

  63. Salem TA, Molloy RG, O’Dwyer PJ (2007) Prospective, five-year follow-up study of patients with symptomatic uncomplicated diverticular disease. Dis Colon Rectum 50(9):1460–1464

    PubMed  Google Scholar 

  64. Broderick-Villa G et al (2005) Hospitalization for acute diverticulitis does not mandate routine elective colectomy. Arch Surg 140(6):576–581 discussion 581-3

    PubMed  Google Scholar 

  65. Chapman JR et al (2006) Diverticulitis: a progressive disease? Do multiple recurrences predict less favorable outcomes? Ann Surg 243(6):876–830 discussion 880-3

    PubMed  PubMed Central  Google Scholar 

  66. Ritz JP et al (2011) Outcome of patients with acute sigmoid diverticulitis: multivariate analysis of risk factors for free perforation. Surgery 149(5):606–613

    PubMed  Google Scholar 

  67. Issa N et al (2009) Emergency surgery for complicated acute diverticulitis. Colorectal Dis 11(2):198–202

    CAS  PubMed  Google Scholar 

  68. Pittet O et al (2009) Recurrent left colonic diverticulitis episodes: more severe than the initial diverticulitis? World J Surg 33(3):547–552

    PubMed  Google Scholar 

  69. Anaya DA, Flum DR (2005) Risk of emergency colectomy and colostomy in patients with diverticular disease. Arch Surg 140(7):681–685

    PubMed  Google Scholar 

  70. Tursi A et al (2005) Assessment of small intestinal bacterial overgrowth in uncomplicated acute diverticulitis of the colon. World J Gastroenterol 11(18):2773–2776

    PubMed  PubMed Central  Google Scholar 

  71. Clemens CH et al (2004) Colorectal visceral perception in diverticular disease. Gut 53(5):717–722

    CAS  PubMed  PubMed Central  Google Scholar 

  72. van de Wall BJ et al (2010) DIRECT trial. Diverticulitis recurrences or continuing symptoms: operative versus conservative treatment. A multicenter randomised clinical trial. BMC Surg 10:25

    PubMed  PubMed Central  Google Scholar 

  73. van de Wall BJM et al (2017) Surgery versus conservative management for recurrent and ongoing left-sided diverticulitis (DIRECT trial): an open-label, multicentre, randomised controlled trial. Lancet Gastroenterol Hepatol 2(1):13–22

    PubMed  Google Scholar 

  74. Bolkenstein HE et al (2019) Long-term outcome of surgery versus conservative management for recurrent and ongoing complaints after an episode of diverticulitis: 5-year follow-up results of a multicenter randomized controlled trial (DIRECT-Trial). Ann Surg 269(4):612–620

    PubMed  Google Scholar 

  75. van Dijk ST et al (2020) A systematic review and meta-analysis of disease severity and risk of recurrence in young versus elderly patients with left-sided acute diverticulitis. Eur J Gastroenterol Hepatol 32(5):547–554

    PubMed  Google Scholar 

  76. Iannone A et al (2018) Mesalazine for people with diverticular disease: a systematic review of randomized controlled trials. Can J Gastroenterol Hepatol 2018:5437135

    PubMed  PubMed Central  Google Scholar 

  77. Tursi A et al (2013) Effectiveness of different therapeutic strategies in preventing diverticulitis recurrence. Eur Rev Med Pharmacol Sci 17(3):342–348

    CAS  PubMed  Google Scholar 

  78. Festa V et al (2017) Retrospective comparison of long-term ten-day/month rifaximin or mesalazine in prevention of relapse in acute diverticulitis. Eur Rev Med Pharmacol Sci 21(6):1397–1404

    CAS  PubMed  Google Scholar 

  79. Dughera L et al (2004) Acute recurrent diverticulitis is prevented by oral administration of a polybacterial lysate suspension. Minerva Gastroenterol Dietol 50(2):149–153

    CAS  PubMed  Google Scholar 

  80. Stollman N et al (2013) A randomized controlled study of mesalamine after acute diverticulitis: results of the DIVA trial. J Clin Gastroenterol 47(7):621–629

    CAS  PubMed  Google Scholar 

  81. Strate LL et al (2013) Heritability and familial aggregation of diverticular disease: a population-based study of twins and siblings. Gastroenterology 144(4):736–742.e1 quiz e14

    PubMed  Google Scholar 

  82. Granlund J et al (2012) The genetic influence on diverticular disease—a twin study. Aliment Pharmacol Ther 35(9):1103–1107

    CAS  PubMed  Google Scholar 

  83. Sigurdsson S et al (2017) Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis. Nat Commun 8:15789

    CAS  PubMed  PubMed Central  Google Scholar 

  84. Maguire LH et al (2018) Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease. Nat Genet 50(10):1359–1365

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Kline BP et al (2019) Multifocal versus conventional unifocal diverticulitis: a comparison of clinical and transcriptomic characteristics. Dig Dis Sci 64(11):3143–3151

    CAS  PubMed  Google Scholar 

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All authors contributed to the literature search and data analysis, drafted the manuscript and approved the final manuscript.

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Correspondence to Des C. Winter.

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Zaborowski, A.M., Winter, D.C. Evidence-based treatment strategies for acute diverticulitis. Int J Colorectal Dis 36, 467–475 (2021). https://doi.org/10.1007/s00384-020-03788-4

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