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Prognostic role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with midgut neuroendocrine tumors undergoing resective surgery

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Aim

Several studies demonstrated the prognostic value of the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and platelet-to-white blood cells ratio (PWR) in different types of tumors. However, there is no information about a possible role of NLR, PLR and PWR as predictor of presence of metastasis or multifocal disease in patients undergoing surgery with curative intent for midgut NET. The aim of our study was to test the role of preoperative NLR, PLR and PWR as predictors of patients undergoing surgery with curative intent for midgut NET.

Methods

We retrospectively enrolled seven foregut, 35 midgut and six hindgut NET patients with gastrointestinal neuroendocrine tumors operated in our Units from January 2005 to June 2016. Details about preoperative laboratory data, surgical operation, histology and follow-up were retrieved. Non-parametric statistics, ROC curve analysis and survival analysis were used.

Results

NLR was significantly higher in patients with distant metastasis (p = 0.04). The ROC curve analysis indicated that a threshold value of NLR of 2.6 predicted the presence of peritoneal metastasis with a specificity of 100% and a sensitivity of 71% and an overall accuracy of AUC = 0.81 (95%CI: 0.59–0.94), p = 0.05. PLR and PWR was not be associated to metastasis but tended to be associated to multifocal disease.

Conclusion

In patients with midgut NET, an impaired adaptive immune response, as suggested by a high NLR ratio, was associated to the presence of distant metastasis and in particular of peritoneal metastasis. This information may be helpful when planning the treatment of a patient with a midgut NET.

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Authors and Affiliations

  1. Department of Surgery, Azienda ULSS2 Marca Trevigiana, 31100, Treviso, Italy

    Anna Pozza, Bruno Pauletti, Nicolò Bassi & Marco Massani

  2. General Surgery Unit, Azienda Ospedaliera di Padova, 35128, Padua, Italy

    Marco Scarpa & Cesare Ruffolo

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  1. Anna Pozza
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  2. Bruno Pauletti
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Contributions

Anna Pozza: study conception and design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of manuscript

Bruno Pauletti: acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of manuscript

Marco Scarpa: study conception and design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of manuscript

Cesare Ruffolo: acquisition of data, drafting of manuscript, critical revision of manuscript

Nicolò Bassi: drafting of manuscript, critical revision of manuscript

Marco Massani: study conception and design, drafting of manuscript, critical revision of manuscript

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Correspondence to Marco Scarpa.

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Pozza, A., Pauletti, B., Scarpa, M. et al. Prognostic role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with midgut neuroendocrine tumors undergoing resective surgery. Int J Colorectal Dis 34, 1849–1856 (2019). https://doi.org/10.1007/s00384-019-03356-5

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