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Prognostic factors for patients with stage II colon cancer: results of a prospective study

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Many studies revealed that the recurrence rate of stage II colon cancer was up to 25–40 %. Regrettably, the risk factors for recurrence of stage II colon cancer remain ambiguous. So, we conducted this study to identify the clinicopathological factors associated with prognosis of stage II colon cancer.

Methods

We enrolled 452 stage II colon cancer patients who underwent radical resection at Peking University Cancer Hospital between January 2007 and December 2010, and 162 patients who received adjuvant treatment were excluded.

Results

The 5-year recurrence rate and overall survival of this cohort were 19.3 (56/290) and 75.9 % (220/290), respectively. In univariate analysis, the following variables were significantly associated with tumor recurrence: male patients (P < 0.001), tumor size >5 cm(P = 0.048), and preoperative carcinoembryonic antigen (CEA) level ≥5 ng/ml (P = 0.004); the following factors were significantly associated with adverse 5-year overall survival: male patients (P < 0.001), age ≥60 years old (P = 0.004), less than 12 lymph nodes (P = 0.006), and preoperative CEA level ≥5 ng/ml (P = 0.011). In multivariate analysis, the preoperative CEA level ≥5 ng/ml (P = 0.003) and male (P < 0.001) were adverse variables significantly associated with tumor recurrence, and the preoperative CEA level ≥5 ng/ml (P = 0.016), male (P < 0.001), and age ≥60 years old (P = 0.008) were independent prognostic factors for the 5-year overall survival rate, respectively.

Conclusions

The preoperative CEA level ≥5 ng/ml and male were undesirable factors significantly associated with tumor recurrence. The preoperative CEA level ≥5 ng/ml, male, and age ≥60 years old were adverse factors significantly associated with poor prognosis.

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Acknowledgments

This study was funded by the National Natural Science Foundation of China (No. 81272766, No. 81450028), the National High Technology Research and Development Program of China (863 Program, No. 2014AA020603), Clinical Characteristics and Application Research of Capital (Beijing Municipal Science and Technology Commission, No. Z121107001012130), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No. XM201309), and Seeding Grant for Medicine and Life Sciences of Peking University (2014-MB-04).

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Minimally Invasive Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, 52 Fu-Cheng Road, Hai-Dian District, Beijing, 100142, China

    Chenghai Zhang, Jiabo Di, Beihai Jiang, Ming Cui, Zaozao Wang, Jiadi Xing, Hong Yang, Zhendan Yao, Nan Zhang & Xiangqian Su

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  1. Chenghai Zhang
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  2. Jiabo Di
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Correspondence to Xiangqian Su.

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Zhang, C., Di, J., Jiang, B. et al. Prognostic factors for patients with stage II colon cancer: results of a prospective study. Int J Colorectal Dis 31, 123–129 (2016). https://doi.org/10.1007/s00384-015-2401-9

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  • DOI: https://doi.org/10.1007/s00384-015-2401-9

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